Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre

Human respiratory syncytial virus (RSV) is an important cause of acute respiratory tract infection in infants and young children. Phylogenetic analysis for RSV in Malaysia has not been reported before. We investigated the genetic features of RSV in respiratory specimens from March to August 2011 wit...

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Main Authors:	Rahman, M.M., Wong, K.K., Isahak, I., Rashid, Z.Z., Alfizah, H.
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2014
Online Access:	http://journalarticle.ukm.my/7155/ http://journalarticle.ukm.my/7155/ http://journalarticle.ukm.my/7155/1/12_M.M._Rahman.pdf

id	ukm-7155
recordtype	eprints
spelling	ukm-71552016-12-14T06:43:15Z http://journalarticle.ukm.my/7155/ Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre Rahman, M.M. Wong, K.K. Isahak, I. Rashid, Z.Z. Alfizah, H. Human respiratory syncytial virus (RSV) is an important cause of acute respiratory tract infection in infants and young children. Phylogenetic analysis for RSV in Malaysia has not been reported before. We investigated the genetic features of RSV in respiratory specimens from March to August 2011 with molecular methods. From a total of 130 throat swab and nasopharyngeal aspirate specimens, 54 (41.5%) were positive with RSV, identified by in-house real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay. Thirty-four out of 54 (63.0%) RSV positive patients were children below two years old and two (1.4%) were adults. Phylogenetic analysis showed 39 isolates were genotype GA5, 13 genotypes GA2, one genotype GA1 and one genotype GA7. The findings indicated four genotypes of RSV circulating in the country and the predominant genotype is GA5. Universiti Kebangsaan Malaysia 2014-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7155/1/12_M.M._Rahman.pdf Rahman, M.M. and Wong, K.K. and Isahak, I. and Rashid, Z.Z. and Alfizah, H. (2014) Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre. Sains Malaysiana, 43 (5). pp. 739-744. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Human respiratory syncytial virus (RSV) is an important cause of acute respiratory tract infection in infants and young children. Phylogenetic analysis for RSV in Malaysia has not been reported before. We investigated the genetic features of RSV in respiratory specimens from March to August 2011 with molecular methods. From a total of 130 throat swab and nasopharyngeal aspirate specimens, 54 (41.5%) were positive with RSV, identified by in-house real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay. Thirty-four out of 54 (63.0%) RSV positive patients were children below two years old and two (1.4%) were adults. Phylogenetic analysis showed 39 isolates were genotype GA5, 13 genotypes GA2, one genotype GA1 and one genotype GA7. The findings indicated four genotypes of RSV circulating in the country and the predominant genotype is GA5.
format	Article
author	Rahman, M.M. Wong, K.K. Isahak, I. Rashid, Z.Z. Alfizah, H.
spellingShingle	Rahman, M.M. Wong, K.K. Isahak, I. Rashid, Z.Z. Alfizah, H. Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre
author_facet	Rahman, M.M. Wong, K.K. Isahak, I. Rashid, Z.Z. Alfizah, H.
author_sort	Rahman, M.M.
title	Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre
title_short	Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre
title_full	Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre
title_fullStr	Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre
title_full_unstemmed	Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre
title_sort	phylogenetic analysis of respiratory syncytial virus identified at universiti kebangsaan malaysia medical centre
publisher	Universiti Kebangsaan Malaysia
publishDate	2014
url	http://journalarticle.ukm.my/7155/ http://journalarticle.ukm.my/7155/ http://journalarticle.ukm.my/7155/1/12_M.M._Rahman.pdf
first_indexed	2023-09-18T19:48:54Z
last_indexed	2023-09-18T19:48:54Z
_version_	1777406086620381184

Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre

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