Biological activities of four Melicope Species

Biological activities of four Melicope Species

The leaves and stem barks extracts of four plant species, Melicope confusa, M. clemensiae, M. lunu-ankenda and M. latifolia were screened for their antimicrobial, antioxidant and cytotoxic activities. Almost all extracts of M. clemensia exhibited moderate growth inhibition when tested against the t...

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Main Authors: Najihah moh Hashim, Mawardi Rahmani, Hazar Bebe Mohd Ismail, Mohd Aspollah Sukari, Manaf Ali .A, Ee Cheng Lian, Gwendoline
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2009
Online Access:http://journalarticle.ukm.my/7/
http://journalarticle.ukm.my/7/
http://journalarticle.ukm.my/7/1/
id ukm-7
recordtype eprints
spelling ukm-72016-12-14T06:26:10Z http://journalarticle.ukm.my/7/ Biological activities of four Melicope Species Najihah moh Hashim, Mawardi Rahmani, Hazar Bebe Mohd Ismail, Mohd Aspollah Sukari, Manaf Ali .A, Ee Cheng Lian, Gwendoline The leaves and stem barks extracts of four plant species, Melicope confusa, M. clemensiae, M. lunu-ankenda and M. latifolia were screened for their antimicrobial, antioxidant and cytotoxic activities. Almost all extracts of M. clemensia exhibited moderate growth inhibition when tested against the three pathogenic fungi. However, when tested against pathogenic bacteria, the three leaves extracts showed strong activity against methicillin resistant S. aureus and moderate for the other bacteria. In the antioxidant assay by using DPPH, the three leaves extracts of M. lunu-ankenda exhibited significant activity with with IC50 values of 7.8, 15.6 and 7.8 μg/mL. In addition, the petroleum ether leaves extract of M. clemensiae and the chloroform leaves extract of M. lunu-ankenda showed strong cytotoxic activity when tested against human promyelocytic leukemia (HL60) cell line with IC50 values of 2.8 and 0.8 μg/mL, respectively. Universiti Kebangsaan Malaysia 2009-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7/1/ Najihah moh Hashim, and Mawardi Rahmani, and Hazar Bebe Mohd Ismail, and Mohd Aspollah Sukari, and Manaf Ali .A, and Ee Cheng Lian, Gwendoline (2009) Biological activities of four Melicope Species. Sains Malaysiana, 38 (5). pp. 767-771. ISSN 0126-6039 http://www.ukm.my/~jsm/kandungan.html
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description The leaves and stem barks extracts of four plant species, Melicope confusa, M. clemensiae, M. lunu-ankenda and M. latifolia were screened for their antimicrobial, antioxidant and cytotoxic activities. Almost all extracts of M. clemensia exhibited moderate growth inhibition when tested against the three pathogenic fungi. However, when tested against pathogenic bacteria, the three leaves extracts showed strong activity against methicillin resistant S. aureus and moderate for the other bacteria. In the antioxidant assay by using DPPH, the three leaves extracts of M. lunu-ankenda exhibited significant activity with with IC50 values of 7.8, 15.6 and 7.8 μg/mL. In addition, the petroleum ether leaves extract of M. clemensiae and the chloroform leaves extract of M. lunu-ankenda showed strong cytotoxic activity when tested against human promyelocytic leukemia (HL60) cell line with IC50 values of 2.8 and 0.8 μg/mL, respectively.
format Article
author Najihah moh Hashim,
Mawardi Rahmani,
Hazar Bebe Mohd Ismail,
Mohd Aspollah Sukari,
Manaf Ali .A,
Ee Cheng Lian, Gwendoline
spellingShingle Najihah moh Hashim,
Mawardi Rahmani,
Hazar Bebe Mohd Ismail,
Mohd Aspollah Sukari,
Manaf Ali .A,
Ee Cheng Lian, Gwendoline
Biological activities of four Melicope Species
author_facet Najihah moh Hashim,
Mawardi Rahmani,
Hazar Bebe Mohd Ismail,
Mohd Aspollah Sukari,
Manaf Ali .A,
Ee Cheng Lian, Gwendoline
author_sort Najihah moh Hashim,
title Biological activities of four Melicope Species
title_short Biological activities of four Melicope Species
title_full Biological activities of four Melicope Species
title_fullStr Biological activities of four Melicope Species
title_full_unstemmed Biological activities of four Melicope Species
title_sort biological activities of four melicope species
publisher Universiti Kebangsaan Malaysia
publishDate 2009
url http://journalarticle.ukm.my/7/
http://journalarticle.ukm.my/7/
http://journalarticle.ukm.my/7/1/
first_indexed 2023-09-18T19:01:10Z
last_indexed 2023-09-18T19:01:10Z
_version_ 1777403083460968448

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