Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.

Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.

Megakaryoblastic leukaemia is the commonest form of leukaemia occuring in Down syndrome infants. However, it’s subtype with translocation t(1;22)(p13;q13)is uncommon comprising <1% of all cases and reported to exclusively occur in infant without Down syndrome. It has a female predominance and car...

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Main Authors: Nurasyikin Y, shenaz SK, Suria AAA, Azma RZ, zarina AL, Hamidah A, Salwati S, Zubaidah Z, Aminah NH
Format: Article
Language:English
Published: Penerbit UKM 2012
Online Access:http://journalarticle.ukm.my/6744/
http://journalarticle.ukm.my/6744/
http://journalarticle.ukm.my/6744/1/07-MS149_%28112-119%29.pdf
id ukm-6744
recordtype eprints
spelling ukm-67442016-12-14T06:42:05Z http://journalarticle.ukm.my/6744/ Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child. Nurasyikin Y, shenaz SK, Suria AAA, Azma RZ, zarina AL, Hamidah A, Salwati S, Zubaidah Z, Aminah NH, Megakaryoblastic leukaemia is the commonest form of leukaemia occuring in Down syndrome infants. However, it’s subtype with translocation t(1;22)(p13;q13)is uncommon comprising <1% of all cases and reported to exclusively occur in infant without Down syndrome. It has a female predominance and carries apoor prognosis. We described this rare form of leukaemia in a 9-month-old girl who presented with bruises, massive hepatosplenomegaly and multiple cervical and inguinal lymphadenopathy. The blood film showed severe anaemia with ovalostomatocytosis, thrombocytopenia and mild leucocytosis. The bone marrow aspirate showed numerous blasts showing high nuclear-cytoplasmic ratio and agranular cytoplasm with cytoplasmic blebs. Peroxidase staining was negative. The immunophenotyping of the blasts showed positive expression of CD117, CD13, CD33 and CD61 which confirmed the diagnosis of acute megakaryoblastic leukaemia. Interestingly, the cytogenetic finding of translocation t(1;22) which is most common in acute megaloblastic leukaemia in infants without Down syndrome was found in this case. She received the AML trial 15 ADE protocol chemotherapy regime and developed severe neutropenic sepsis and respiratory distress requiring ventilatory support and granulocyte colony stimulating factor (G-CSF). She recovered wellmafter the first course of chemotherapy and was discharged. Unfortunately, she was not brought in for follow-up chemotherapy and presented a few months later with relapsed AML. She was re-started on ADE protocol and currently is on oral thioguanine for maintenance therapy. Penerbit UKM 2012-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6744/1/07-MS149_%28112-119%29.pdf Nurasyikin Y, and shenaz SK, and Suria AAA, and Azma RZ, and zarina AL, and Hamidah A, and Salwati S, and Zubaidah Z, and Aminah NH, (2012) Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child. Medicine & Health, 7 (2). pp. 112-119. ISSN 1823-2140 http://www.medicineandhealthukm.com/
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description Megakaryoblastic leukaemia is the commonest form of leukaemia occuring in Down syndrome infants. However, it’s subtype with translocation t(1;22)(p13;q13)is uncommon comprising <1% of all cases and reported to exclusively occur in infant without Down syndrome. It has a female predominance and carries apoor prognosis. We described this rare form of leukaemia in a 9-month-old girl who presented with bruises, massive hepatosplenomegaly and multiple cervical and inguinal lymphadenopathy. The blood film showed severe anaemia with ovalostomatocytosis, thrombocytopenia and mild leucocytosis. The bone marrow aspirate showed numerous blasts showing high nuclear-cytoplasmic ratio and agranular cytoplasm with cytoplasmic blebs. Peroxidase staining was negative. The immunophenotyping of the blasts showed positive expression of CD117, CD13, CD33 and CD61 which confirmed the diagnosis of acute megakaryoblastic leukaemia. Interestingly, the cytogenetic finding of translocation t(1;22) which is most common in acute megaloblastic leukaemia in infants without Down syndrome was found in this case. She received the AML trial 15 ADE protocol chemotherapy regime and developed severe neutropenic sepsis and respiratory distress requiring ventilatory support and granulocyte colony stimulating factor (G-CSF). She recovered wellmafter the first course of chemotherapy and was discharged. Unfortunately, she was not brought in for follow-up chemotherapy and presented a few months later with relapsed AML. She was re-started on ADE protocol and currently is on oral thioguanine for maintenance therapy.
format Article
author Nurasyikin Y,
shenaz SK,
Suria AAA,
Azma RZ,
zarina AL,
Hamidah A,
Salwati S,
Zubaidah Z,
Aminah NH,
spellingShingle Nurasyikin Y,
shenaz SK,
Suria AAA,
Azma RZ,
zarina AL,
Hamidah A,
Salwati S,
Zubaidah Z,
Aminah NH,
Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.
author_facet Nurasyikin Y,
shenaz SK,
Suria AAA,
Azma RZ,
zarina AL,
Hamidah A,
Salwati S,
Zubaidah Z,
Aminah NH,
author_sort Nurasyikin Y,
title Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.
title_short Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.
title_full Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.
title_fullStr Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.
title_full_unstemmed Infantile acute megakaryoblastic leukaemia with T(1:22) in a non-down syndrome child.
title_sort infantile acute megakaryoblastic leukaemia with t(1:22) in a non-down syndrome child.
publisher Penerbit UKM
publishDate 2012
url http://journalarticle.ukm.my/6744/
http://journalarticle.ukm.my/6744/
http://journalarticle.ukm.my/6744/1/07-MS149_%28112-119%29.pdf
first_indexed 2023-09-18T19:47:46Z
last_indexed 2023-09-18T19:47:46Z
_version_ 1777406014795022336

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