Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats

Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats

Piper sarmentosum has been shown to possess antihyperglycemic effect. The effect of water extract of PS leaves was determined on the diabetic complications in streptozotocin induced rats. Eighteen male Sprague Dawley rats (n=18) were randomly divided into three groups with six rats each, namely, con...

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Main Authors: Farida Hussan, Nur Nazilah Mat Zin, Mohd Ramdzi Zullkefli, Yow, Siew Choon, Noor Adibah Abdullah, Teoh, Seong Lin
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2013
Online Access:http://journalarticle.ukm.my/6625/
http://journalarticle.ukm.my/6625/
http://journalarticle.ukm.my/6625/1/10_Farida_Hussan-2.pdf
id ukm-6625
recordtype eprints
spelling ukm-66252016-12-14T06:41:44Z http://journalarticle.ukm.my/6625/ Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats Farida Hussan, Nur Nazilah Mat Zin, Mohd Ramdzi Zullkefli, Yow, Siew Choon Noor Adibah Abdullah, Teoh, Seong Lin Piper sarmentosum has been shown to possess antihyperglycemic effect. The effect of water extract of PS leaves was determined on the diabetic complications in streptozotocin induced rats. Eighteen male Sprague Dawley rats (n=18) were randomly divided into three groups with six rats each, namely, control, diabetic untreated and PS treated diabetic groups. Diabetes was induced with intramuscular injection of STZ (50 mg/kg). Ten days following the induction, the diabetes was confirmed with fasting blood sugar level more than 8 mmol/L and PS extract was administered orally (0.125 g/kg) for 28 days. The left kidneys were collected to analyze. The body weight and kidney weight index showed significant differences between control and diabetic groups (p<0.05). However, the lesser extent of body weight gain was observed in diabetic group compared with the control groups. The fasting blood sugar level was reduced in PS treated group. The percent area occupied by the glomerulus over a renal corpuscle was found to be 74.5% in DPS, 72% in DNT and 75% in C group; however it was statistically insignificant. Histological study revealed marked inflammatory cells infiltration and glomeruli contraction with widened urinary spaces revealed in DNT group following 28 days of hyperglycemic state whereas the DPS group showed features of improvement. The water extract of PS leaves has the potential preventive effect on the diabetic nephropathy by reducing hyperglycemia. Universiti Kebangsaan Malaysia 2013-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6625/1/10_Farida_Hussan-2.pdf Farida Hussan, and Nur Nazilah Mat Zin, and Mohd Ramdzi Zullkefli, and Yow, Siew Choon and Noor Adibah Abdullah, and Teoh, Seong Lin (2013) Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats. Sains Malaysiana, 42 (11). pp. 1605-1612. ISSN 0126-6039 http://www.ukm.my/jsm/
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institution Universiti Kebangasaan Malaysia
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description Piper sarmentosum has been shown to possess antihyperglycemic effect. The effect of water extract of PS leaves was determined on the diabetic complications in streptozotocin induced rats. Eighteen male Sprague Dawley rats (n=18) were randomly divided into three groups with six rats each, namely, control, diabetic untreated and PS treated diabetic groups. Diabetes was induced with intramuscular injection of STZ (50 mg/kg). Ten days following the induction, the diabetes was confirmed with fasting blood sugar level more than 8 mmol/L and PS extract was administered orally (0.125 g/kg) for 28 days. The left kidneys were collected to analyze. The body weight and kidney weight index showed significant differences between control and diabetic groups (p<0.05). However, the lesser extent of body weight gain was observed in diabetic group compared with the control groups. The fasting blood sugar level was reduced in PS treated group. The percent area occupied by the glomerulus over a renal corpuscle was found to be 74.5% in DPS, 72% in DNT and 75% in C group; however it was statistically insignificant. Histological study revealed marked inflammatory cells infiltration and glomeruli contraction with widened urinary spaces revealed in DNT group following 28 days of hyperglycemic state whereas the DPS group showed features of improvement. The water extract of PS leaves has the potential preventive effect on the diabetic nephropathy by reducing hyperglycemia.
format Article
author Farida Hussan,
Nur Nazilah Mat Zin,
Mohd Ramdzi Zullkefli,
Yow, Siew Choon
Noor Adibah Abdullah,
Teoh, Seong Lin
spellingShingle Farida Hussan,
Nur Nazilah Mat Zin,
Mohd Ramdzi Zullkefli,
Yow, Siew Choon
Noor Adibah Abdullah,
Teoh, Seong Lin
Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats
author_facet Farida Hussan,
Nur Nazilah Mat Zin,
Mohd Ramdzi Zullkefli,
Yow, Siew Choon
Noor Adibah Abdullah,
Teoh, Seong Lin
author_sort Farida Hussan,
title Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats
title_short Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats
title_full Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats
title_fullStr Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats
title_full_unstemmed Piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats
title_sort piper sarmentosum water extract attenuates diabetic complications in streptozotocin induced sprague-dawley rats
publisher Universiti Kebangsaan Malaysia
publishDate 2013
url http://journalarticle.ukm.my/6625/
http://journalarticle.ukm.my/6625/
http://journalarticle.ukm.my/6625/1/10_Farida_Hussan-2.pdf
first_indexed 2023-09-18T19:47:27Z
last_indexed 2023-09-18T19:47:27Z
_version_ 1777405995293605888

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