Xanthones from calophyllum gracilipes and their cytotoxic activity

Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigm...

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Main Authors:	Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea, Stanslas, Johnson, Ethel Jeyaseela Jeyaraj
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2013
Online Access:	http://journalarticle.ukm.my/6468/ http://journalarticle.ukm.my/6468/ http://journalarticle.ukm.my/6468/1/08_Nadiah_Mad_Nasir.pdf

id	ukm-6468
recordtype	eprints
spelling	ukm-64682016-12-14T06:41:16Z http://journalarticle.ukm.my/6468/ Xanthones from calophyllum gracilipes and their cytotoxic activity Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea Stanslas, Johnson Ethel Jeyaseela Jeyaraj, Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00 μΜ. Universiti Kebangsaan Malaysia 2013-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6468/1/08_Nadiah_Mad_Nasir.pdf Nadiah Mad Nasir, and Mawardi Rahmani, and Khozirah Shaari, and Nur Kartinee Kassim, and Go, Rusea and Stanslas, Johnson and Ethel Jeyaseela Jeyaraj, (2013) Xanthones from calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana, 42 (9). pp. 1261-1266. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00 μΜ.
format	Article
author	Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea Stanslas, Johnson Ethel Jeyaseela Jeyaraj,
spellingShingle	Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea Stanslas, Johnson Ethel Jeyaseela Jeyaraj, Xanthones from calophyllum gracilipes and their cytotoxic activity
author_facet	Nadiah Mad Nasir, Mawardi Rahmani, Khozirah Shaari, Nur Kartinee Kassim, Go, Rusea Stanslas, Johnson Ethel Jeyaseela Jeyaraj,
author_sort	Nadiah Mad Nasir,
title	Xanthones from calophyllum gracilipes and their cytotoxic activity
title_short	Xanthones from calophyllum gracilipes and their cytotoxic activity
title_full	Xanthones from calophyllum gracilipes and their cytotoxic activity
title_fullStr	Xanthones from calophyllum gracilipes and their cytotoxic activity
title_full_unstemmed	Xanthones from calophyllum gracilipes and their cytotoxic activity
title_sort	xanthones from calophyllum gracilipes and their cytotoxic activity
publisher	Universiti Kebangsaan Malaysia
publishDate	2013
url	http://journalarticle.ukm.my/6468/ http://journalarticle.ukm.my/6468/ http://journalarticle.ukm.my/6468/1/08_Nadiah_Mad_Nasir.pdf
first_indexed	2023-09-18T19:47:00Z
last_indexed	2023-09-18T19:47:00Z
_version_	1777405967462301696

Xanthones from calophyllum gracilipes and their cytotoxic activity

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