Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats

Cosmos caudatus or ‘ulam raja’ is a local plant with antioxidant properties and has the potential to treat free radicals-associated diseases. However, its toxic effects need to be elucidated. Acute toxicity study was carried out in male rats. Rats aged 3 months, weighing 150-200 g were divided into...

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Main Authors:	M. Norazlina, S.Z., Ehsan, K., Noor 'Adilah, C.P., Lee, E., Farhana, P., Derick, S., Ima-Nirwana, A.S., Nazrun, M., Norliza
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2013
Online Access:	http://journalarticle.ukm.my/6466/ http://journalarticle.ukm.my/6466/ http://journalarticle.ukm.my/6466/1/06_M._Norazlina.pdf

id	ukm-6466
recordtype	eprints
spelling	ukm-64662016-12-14T06:41:15Z http://journalarticle.ukm.my/6466/ Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats M. Norazlina, S.Z., Ehsan K., Noor 'Adilah C.P., Lee E., Farhana P., Derick S., Ima-Nirwana A.S., Nazrun M., Norliza Cosmos caudatus or ‘ulam raja’ is a local plant with antioxidant properties and has the potential to treat free radicals-associated diseases. However, its toxic effects need to be elucidated. Acute toxicity study was carried out in male rats. Rats aged 3 months, weighing 150-200 g were divided into 4 groups, i.e. rats being fed on distilled water (control), Cosmos caudatus extract dose 50 mg/kg (CC50), Cosmos caudatus 500 mg/kg (CC500) and Cosmos caudatus 2000 mg/kg (CC2000), respectively. A single treatment was given to the respective groups and the animals were sacrificed after 7 days. Biochemical parameters before and after treatment were measured. Liver enzymes, i.e. alkaline phosphatase (ALP) and alanine transaminase (ALT), were found to be increased post treatment in CC500 and CC2000 groups. Creatinine levels were lower in CC500 and CC2000 groups post treatment compared with control group while albumin levels were lower in CC2000 group than all the other groups. In conclusion, Cosmos caudatus may cause acute hepatotoxicity at high doses. Universiti Kebangsaan Malaysia 2013-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6466/1/06_M._Norazlina.pdf M. Norazlina, and S.Z., Ehsan and K., Noor 'Adilah and C.P., Lee and E., Farhana and P., Derick and S., Ima-Nirwana and A.S., Nazrun and M., Norliza (2013) Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats. Sains Malaysiana, 42 (9). pp. 1237-1246. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Cosmos caudatus or ‘ulam raja’ is a local plant with antioxidant properties and has the potential to treat free radicals-associated diseases. However, its toxic effects need to be elucidated. Acute toxicity study was carried out in male rats. Rats aged 3 months, weighing 150-200 g were divided into 4 groups, i.e. rats being fed on distilled water (control), Cosmos caudatus extract dose 50 mg/kg (CC50), Cosmos caudatus 500 mg/kg (CC500) and Cosmos caudatus 2000 mg/kg (CC2000), respectively. A single treatment was given to the respective groups and the animals were sacrificed after 7 days. Biochemical parameters before and after treatment were measured. Liver enzymes, i.e. alkaline phosphatase (ALP) and alanine transaminase (ALT), were found to be increased post treatment in CC500 and CC2000 groups. Creatinine levels were lower in CC500 and CC2000 groups post treatment compared with control group while albumin levels were lower in CC2000 group than all the other groups. In conclusion, Cosmos caudatus may cause acute hepatotoxicity at high doses.
format	Article
author	M. Norazlina, S.Z., Ehsan K., Noor 'Adilah C.P., Lee E., Farhana P., Derick S., Ima-Nirwana A.S., Nazrun M., Norliza
spellingShingle	M. Norazlina, S.Z., Ehsan K., Noor 'Adilah C.P., Lee E., Farhana P., Derick S., Ima-Nirwana A.S., Nazrun M., Norliza Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
author_facet	M. Norazlina, S.Z., Ehsan K., Noor 'Adilah C.P., Lee E., Farhana P., Derick S., Ima-Nirwana A.S., Nazrun M., Norliza
author_sort	M. Norazlina,
title	Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_short	Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_full	Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_fullStr	Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_full_unstemmed	Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_sort	acute toxicity study of cosmos caudatus on biochemical parameters in male rats
publisher	Universiti Kebangsaan Malaysia
publishDate	2013
url	http://journalarticle.ukm.my/6466/ http://journalarticle.ukm.my/6466/ http://journalarticle.ukm.my/6466/1/06_M._Norazlina.pdf
first_indexed	2023-09-18T19:47:00Z
last_indexed	2023-09-18T19:47:00Z
_version_	1777405967173943296

Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats

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