Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors

Menopause is the most prevalent cause of accelerated bone loss in women. Biochemical markers of bone resorption can be used clinically to predict future bone loss. This study aimed to determine the level of bone resorption markers in healthy pre and postmenopausal Malay women and determine their ass...

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Main Authors:	Hermizi Hapidin, Hawa Mahmood, Sakinah Harith
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2013
Online Access:	http://journalarticle.ukm.my/6459/ http://journalarticle.ukm.my/6459/ http://journalarticle.ukm.my/6459/1/20_Hermizi_Hapidin.pdf

id	ukm-6459
recordtype	eprints
spelling	ukm-64592016-12-14T06:41:14Z http://journalarticle.ukm.my/6459/ Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors Hermizi Hapidin, Hawa Mahmood, Sakinah Harith, Menopause is the most prevalent cause of accelerated bone loss in women. Biochemical markers of bone resorption can be used clinically to predict future bone loss. This study aimed to determine the level of bone resorption markers in healthy pre and postmenopausal Malay women and determine their association with the risk. A total of 150 healthy women were recruited for this study (51 pre and 99 postmenopausal subjects). Data on socioeconomic, lifestyle habit and clinical were gained by personal interview. Fasting serum was collected to measure both C-telopeptide (CTx) and N-telopeptide (NTx) of type 1 collagen. Both markers were highly correlated with each other (r=0.568, p<0.001). Both intra- and inter-assay coefficient of variations (CV) of NTx were higher than those of CTx (8% and 12% vs 6% and 5%). The mean CTx values of pre and postmenopausal subjects were comparable with the expected values (0.2833 (0.1769) ng/mL and 0.4323 (1.851) ng/mL compared with 0.287 and 0.438 ng/mL, respectively). The NTx value for premenopausal subjects were higher than the expected values (15.2 (8.10) compared to 12.6 (3.20) nM BCE). The median was 19.929 nM BCE. The mean CTx and NTx levels of postmenopausal subjects were significantly lower than premenopausal subjects (p<0.05). The risk factors for bone resorption in this population were duration of menopause, marital status, body mass index (BMI), physical activity and education level. In conclusion, postmenopausal women showed a higher bone resorption, indicating higher bone loss. Increasing education and physical activity intervention might be effective to ensure better health in Malaysian older population. Universiti Kebangsaan Malaysia 2013-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6459/1/20_Hermizi_Hapidin.pdf Hermizi Hapidin, and Hawa Mahmood, and Sakinah Harith, (2013) Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors. Sains Malaysiana, 42 (8). pp. 1191-1200. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Menopause is the most prevalent cause of accelerated bone loss in women. Biochemical markers of bone resorption can be used clinically to predict future bone loss. This study aimed to determine the level of bone resorption markers in healthy pre and postmenopausal Malay women and determine their association with the risk. A total of 150 healthy women were recruited for this study (51 pre and 99 postmenopausal subjects). Data on socioeconomic, lifestyle habit and clinical were gained by personal interview. Fasting serum was collected to measure both C-telopeptide (CTx) and N-telopeptide (NTx) of type 1 collagen. Both markers were highly correlated with each other (r=0.568, p<0.001). Both intra- and inter-assay coefficient of variations (CV) of NTx were higher than those of CTx (8% and 12% vs 6% and 5%). The mean CTx values of pre and postmenopausal subjects were comparable with the expected values (0.2833 (0.1769) ng/mL and 0.4323 (1.851) ng/mL compared with 0.287 and 0.438 ng/mL, respectively). The NTx value for premenopausal subjects were higher than the expected values (15.2 (8.10) compared to 12.6 (3.20) nM BCE). The median was 19.929 nM BCE. The mean CTx and NTx levels of postmenopausal subjects were significantly lower than premenopausal subjects (p<0.05). The risk factors for bone resorption in this population were duration of menopause, marital status, body mass index (BMI), physical activity and education level. In conclusion, postmenopausal women showed a higher bone resorption, indicating higher bone loss. Increasing education and physical activity intervention might be effective to ensure better health in Malaysian older population.
format	Article
author	Hermizi Hapidin, Hawa Mahmood, Sakinah Harith,
spellingShingle	Hermizi Hapidin, Hawa Mahmood, Sakinah Harith, Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors
author_facet	Hermizi Hapidin, Hawa Mahmood, Sakinah Harith,
author_sort	Hermizi Hapidin,
title	Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors
title_short	Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors
title_full	Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors
title_fullStr	Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors
title_full_unstemmed	Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors
title_sort	bone resorption marker status of pre and postmenopausal malay women in kelantan and its corresponding risk factors
publisher	Universiti Kebangsaan Malaysia
publishDate	2013
url	http://journalarticle.ukm.my/6459/ http://journalarticle.ukm.my/6459/ http://journalarticle.ukm.my/6459/1/20_Hermizi_Hapidin.pdf
first_indexed	2023-09-18T19:46:56Z
last_indexed	2023-09-18T19:46:56Z
_version_	1777405963200888832

Bone resorption marker status of pre and postmenopausal malay women in Kelantan and its corresponding risk factors

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