Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats

Abundant natural products with medicinal properties have been used as food and traditional medicine for diabetes mellitus all over the world. Psidium guajava fruit from the family of Myrtaceae has gained attention for its antioxidant potential. This study was conducted to determine the effects of P....

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Main Authors:	Siti Balkis Budin, Hawa Ismail, Pek, Lian Chong
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2013
Online Access:	http://journalarticle.ukm.my/6273/ http://journalarticle.ukm.my/6273/ http://journalarticle.ukm.my/6273/1/02_Siti_Balkis.pdf

id	ukm-6273
recordtype	eprints
spelling	ukm-62732016-12-14T06:40:42Z http://journalarticle.ukm.my/6273/ Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats Siti Balkis Budin, Hawa Ismail, Pek, Lian Chong Abundant natural products with medicinal properties have been used as food and traditional medicine for diabetes mellitus all over the world. Psidium guajava fruit from the family of Myrtaceae has gained attention for its antioxidant potential. This study was conducted to determine the effects of P. guajava fruit peel aqueous extract on oxidative stress of pancreas in streptozotocin-induced (45 mg/kg) diabetic rats. Diabetic rats were administered with 400 mg/kg of aqueous extract of P. guajava fruit peel daily for 28 days duration. The results showed that diabetic rats supplemented with P. guajava extract did not cause significant difference in blood glucose level (p>0.05) as compared with diabetic rats alone. For oxidative stress evaluation, malondialdehyde (MDA) and protein carbonyl level were significantly lower and the activity of superoxide dismutase (SOD) and glutathione (GSH) level were significantly higher (p<0.05) in P. guajava supplemented rats compared with non-supplemented diabetic rats. However, histological observation showed that supplementation of P. guajava extract did not give protective effects towards alterations in pancreas histology in diabetic rats. The findings suggested that aqueous extract of P. guajava fruit peel supplementation has the ability to reduce oxidative stress in pancreas of diabetic rats and may play a role in reducing the development of diabetic complications. Universiti Kebangsaan Malaysia 2013-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6273/1/02_Siti_Balkis.pdf Siti Balkis Budin, and Hawa Ismail, and Pek, Lian Chong (2013) Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats. Sains Malaysiana, 42 (6). pp. 707-713. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Abundant natural products with medicinal properties have been used as food and traditional medicine for diabetes mellitus all over the world. Psidium guajava fruit from the family of Myrtaceae has gained attention for its antioxidant potential. This study was conducted to determine the effects of P. guajava fruit peel aqueous extract on oxidative stress of pancreas in streptozotocin-induced (45 mg/kg) diabetic rats. Diabetic rats were administered with 400 mg/kg of aqueous extract of P. guajava fruit peel daily for 28 days duration. The results showed that diabetic rats supplemented with P. guajava extract did not cause significant difference in blood glucose level (p>0.05) as compared with diabetic rats alone. For oxidative stress evaluation, malondialdehyde (MDA) and protein carbonyl level were significantly lower and the activity of superoxide dismutase (SOD) and glutathione (GSH) level were significantly higher (p<0.05) in P. guajava supplemented rats compared with non-supplemented diabetic rats. However, histological observation showed that supplementation of P. guajava extract did not give protective effects towards alterations in pancreas histology in diabetic rats. The findings suggested that aqueous extract of P. guajava fruit peel supplementation has the ability to reduce oxidative stress in pancreas of diabetic rats and may play a role in reducing the development of diabetic complications.
format	Article
author	Siti Balkis Budin, Hawa Ismail, Pek, Lian Chong
spellingShingle	Siti Balkis Budin, Hawa Ismail, Pek, Lian Chong Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
author_facet	Siti Balkis Budin, Hawa Ismail, Pek, Lian Chong
author_sort	Siti Balkis Budin,
title	Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_short	Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_full	Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_fullStr	Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_full_unstemmed	Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_sort	psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
publisher	Universiti Kebangsaan Malaysia
publishDate	2013
url	http://journalarticle.ukm.my/6273/ http://journalarticle.ukm.my/6273/ http://journalarticle.ukm.my/6273/1/02_Siti_Balkis.pdf
first_indexed	2023-09-18T19:46:26Z
last_indexed	2023-09-18T19:46:26Z
_version_	1777405931100831744

Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats

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