Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema

Hypercholesterolemia is often associated with changes in lipid profile and an increase in lipid peroxidation level. In this study, the effects of peel and flesh aqueous extracts of Hylocereus polyrhizus (HP) fruit on serum total cholesterol and triglyceride (TG) and liver malondialdehyde (MDA-TBAR)...

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Main Authors:	Halimah Abdullah Sani, Asmazila Baharoom, Muhammad Azam Ahmad, Isma Illyani Ismail
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2009
Online Access:	http://journalarticle.ukm.my/60/ http://journalarticle.ukm.my/60/ http://journalarticle.ukm.my/60/1/

id	ukm-60
recordtype	eprints
spelling	ukm-602016-12-14T06:26:17Z http://journalarticle.ukm.my/60/ Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema Halimah Abdullah Sani, Asmazila Baharoom, Muhammad Azam Ahmad, Isma Illyani Ismail, Hypercholesterolemia is often associated with changes in lipid profile and an increase in lipid peroxidation level. In this study, the effects of peel and flesh aqueous extracts of Hylocereus polyrhizus (HP) fruit on serum total cholesterol and triglyceride (TG) and liver malondialdehyde (MDA-TBAR) levels in hypercholesterolemic rats were evaluated. Male Sprague dawley rats were induced into hypercholesterolemia by giving rat chow diet plus 15% pure ghee for 8 weeks and forced-fed with 0.02 g cholesterol in 0.5 ml ghee twice a week. Rats were then treated with 300 mg/kg (body weight) of peel and flesh extracts of H. polyrhizus fruit via force feeding for 10 days. The results show that total cholesterol level was reduced significantly (p<0.05) in both hypercholesterolemic groups treated with peel and flesh extracts by 51.36% and 43.53% respectively. The TG level showed a reduction by 42.98% in peel extract treated group and 38.0% in rats treated flesh extract. The increase in liver MDA-TBAR level was inhibited by 56.85% in group treated with peel extract (p<0.05) whereas the flesh extract only caused a slight decrease by 10.27% compared to the untreated diabetic group. In this study, the peel aqueous extract of H. polyrhizus showed a greater effect than the flesh extract. This could be due to the higher content of antioxidant betacyanin in the fruit peel than in the flesh. Hylocereus polyrhizus aqueous extract have the potential in lowering the lipid profile and liver MDA-TBAR level in hypercholesterolemic rats. Universiti Kebangsaan Malaysia 2009-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/60/1/ Halimah Abdullah Sani, and Asmazila Baharoom, and Muhammad Azam Ahmad, and Isma Illyani Ismail, (2009) Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema. Sains Malaysiana, 38 (2). pp. 271-279. ISSN 0126-6039 http://www.ukm.my/~jsm/kandungan.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Hypercholesterolemia is often associated with changes in lipid profile and an increase in lipid peroxidation level. In this study, the effects of peel and flesh aqueous extracts of Hylocereus polyrhizus (HP) fruit on serum total cholesterol and triglyceride (TG) and liver malondialdehyde (MDA-TBAR) levels in hypercholesterolemic rats were evaluated. Male Sprague dawley rats were induced into hypercholesterolemia by giving rat chow diet plus 15% pure ghee for 8 weeks and forced-fed with 0.02 g cholesterol in 0.5 ml ghee twice a week. Rats were then treated with 300 mg/kg (body weight) of peel and flesh extracts of H. polyrhizus fruit via force feeding for 10 days. The results show that total cholesterol level was reduced significantly (p<0.05) in both hypercholesterolemic groups treated with peel and flesh extracts by 51.36% and 43.53% respectively. The TG level showed a reduction by 42.98% in peel extract treated group and 38.0% in rats treated flesh extract. The increase in liver MDA-TBAR level was inhibited by 56.85% in group treated with peel extract (p<0.05) whereas the flesh extract only caused a slight decrease by 10.27% compared to the untreated diabetic group. In this study, the peel aqueous extract of H. polyrhizus showed a greater effect than the flesh extract. This could be due to the higher content of antioxidant betacyanin in the fruit peel than in the flesh. Hylocereus polyrhizus aqueous extract have the potential in lowering the lipid profile and liver MDA-TBAR level in hypercholesterolemic rats.
format	Article
author	Halimah Abdullah Sani, Asmazila Baharoom, Muhammad Azam Ahmad, Isma Illyani Ismail,
spellingShingle	Halimah Abdullah Sani, Asmazila Baharoom, Muhammad Azam Ahmad, Isma Illyani Ismail, Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema
author_facet	Halimah Abdullah Sani, Asmazila Baharoom, Muhammad Azam Ahmad, Isma Illyani Ismail,
author_sort	Halimah Abdullah Sani,
title	Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema
title_short	Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema
title_full	Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema
title_fullStr	Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema
title_full_unstemmed	Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema
title_sort	keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras mda-tbar hati tikus teraruh hiperkolesterolema
publisher	Universiti Kebangsaan Malaysia
publishDate	2009
url	http://journalarticle.ukm.my/60/ http://journalarticle.ukm.my/60/ http://journalarticle.ukm.my/60/1/
first_indexed	2023-09-18T19:01:09Z
last_indexed	2023-09-18T19:01:09Z
_version_	1777403082009739264

Keberkesanan ekstrak hylocereus polyrhizus merendahkan lipid serum dan aras MDA-TBAR hati tikus teraruh hiperkolesterolema

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