Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia

The aim of this study was to determine the relationships between ApoE genotypes and ‘behavioural and psychological symptoms of dementia’ (BPSD). A cross-sectional study was conducted on 46 outpatients with dementia (aged 60 and above) and their caregivers attending the psychogeriatric clinics at Uni...

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Main Authors:	Rosdinom Razali, Zanariah Mat Saher, Elinda Tunan, Wan Zurinah Wan Ngah, Then, Sue-Mian, Suriati Mohamed Saini, Abdul Hamid Abdul Rahman, Shamsul Azhar Shah
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2013
Online Access:	http://journalarticle.ukm.my/5987/ http://journalarticle.ukm.my/5987/ http://journalarticle.ukm.my/5987/1/19%2520Rosdinom.pdf

id	ukm-5987
recordtype	eprints
spelling	ukm-59872016-12-14T06:40:02Z http://journalarticle.ukm.my/5987/ Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia Rosdinom Razali, Zanariah Mat Saher, Elinda Tunan, Wan Zurinah Wan Ngah, Then, Sue-Mian Suriati Mohamed Saini, Abdul Hamid Abdul Rahman, Shamsul Azhar Shah, The aim of this study was to determine the relationships between ApoE genotypes and ‘behavioural and psychological symptoms of dementia’ (BPSD). A cross-sectional study was conducted on 46 outpatients with dementia (aged 60 and above) and their caregivers attending the psychogeriatric clinics at Universiti Kebangsaan Malaysia Medical Centre (UKMMC) and Hospital Kuala Lumpur. Neuropsychiatric Inventory (NPI) was used for the assessment of BPSD. The patients’ blood samples were taken for Apolipoprotein genotyping after consented by the caregivers. There were more female (69.6%) and Chinese (50%) patients with a mean age of 73.7 years. ApoE ε3/ε3 was the most common ApoE allele (60.7%) and mostly found in Chinese patients. ApoE genotype was significantly associated with ethnicity (p=0.03) and marital status (p=0.01). Alzheimer disease was the most common subtype of dementia (41.3%) and the highest carrier of ApoE ε3/ε3 (30.4%). The ApoE ε4/ ε4 scored highest in BPSD median score 44 (17.5 to 90) but the relationships between ApoE genotypes and subtypes of dementia or BPSD scores were not significant (p=0.20; p=0.64). Agitation was the most common symptom, with delusions showing the highest scores on the NPI with no significant association to ApoE 4 allele. In conclusion, there was no significant relationship between ApoE genotypes and severity or types of BPSD in dementia patients. Universiti Kebangsaan Malaysia 2013-03 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5987/1/19%2520Rosdinom.pdf Rosdinom Razali, and Zanariah Mat Saher, and Elinda Tunan, and Wan Zurinah Wan Ngah, and Then, Sue-Mian and Suriati Mohamed Saini, and Abdul Hamid Abdul Rahman, and Shamsul Azhar Shah, (2013) Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia. Sains Malaysiana, 42 (3). pp. 409-416. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The aim of this study was to determine the relationships between ApoE genotypes and ‘behavioural and psychological symptoms of dementia’ (BPSD). A cross-sectional study was conducted on 46 outpatients with dementia (aged 60 and above) and their caregivers attending the psychogeriatric clinics at Universiti Kebangsaan Malaysia Medical Centre (UKMMC) and Hospital Kuala Lumpur. Neuropsychiatric Inventory (NPI) was used for the assessment of BPSD. The patients’ blood samples were taken for Apolipoprotein genotyping after consented by the caregivers. There were more female (69.6%) and Chinese (50%) patients with a mean age of 73.7 years. ApoE ε3/ε3 was the most common ApoE allele (60.7%) and mostly found in Chinese patients. ApoE genotype was significantly associated with ethnicity (p=0.03) and marital status (p=0.01). Alzheimer disease was the most common subtype of dementia (41.3%) and the highest carrier of ApoE ε3/ε3 (30.4%). The ApoE ε4/ ε4 scored highest in BPSD median score 44 (17.5 to 90) but the relationships between ApoE genotypes and subtypes of dementia or BPSD scores were not significant (p=0.20; p=0.64). Agitation was the most common symptom, with delusions showing the highest scores on the NPI with no significant association to ApoE 4 allele. In conclusion, there was no significant relationship between ApoE genotypes and severity or types of BPSD in dementia patients.
format	Article
author	Rosdinom Razali, Zanariah Mat Saher, Elinda Tunan, Wan Zurinah Wan Ngah, Then, Sue-Mian Suriati Mohamed Saini, Abdul Hamid Abdul Rahman, Shamsul Azhar Shah,
spellingShingle	Rosdinom Razali, Zanariah Mat Saher, Elinda Tunan, Wan Zurinah Wan Ngah, Then, Sue-Mian Suriati Mohamed Saini, Abdul Hamid Abdul Rahman, Shamsul Azhar Shah, Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia
author_facet	Rosdinom Razali, Zanariah Mat Saher, Elinda Tunan, Wan Zurinah Wan Ngah, Then, Sue-Mian Suriati Mohamed Saini, Abdul Hamid Abdul Rahman, Shamsul Azhar Shah,
author_sort	Rosdinom Razali,
title	Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia
title_short	Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia
title_full	Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia
title_fullStr	Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia
title_full_unstemmed	Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia
title_sort	apolipoprotein e genotypes and behavioural and psychological symptoms of dementia (bpsd) in malaysian patients with dementia
publisher	Universiti Kebangsaan Malaysia
publishDate	2013
url	http://journalarticle.ukm.my/5987/ http://journalarticle.ukm.my/5987/ http://journalarticle.ukm.my/5987/1/19%2520Rosdinom.pdf
first_indexed	2023-09-18T19:45:41Z
last_indexed	2023-09-18T19:45:41Z
_version_	1777405883829977088

Apolipoprotein E genotypes and behavioural and psychological symptoms of dementia (BPSD) in Malaysian patients with dementia

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