Motor neurological soft signs among patients with schizophrenia: a clinical significance

Neurological soft signs (NSS) are subtle indicators of brain dysfunction which are present in excess among patients with schizophrenia. Its clinical significance remains unclear despite extensive researches in this area. The objective of this work was to determine the proportion of Schizophrenia pat...

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Main Authors:	Hazli Zakaria, Nik Ruzyanei Nik Jaafar, Azlin Baharuddin, Normala Ibrahim, Marhani Midin
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2013
Online Access:	http://journalarticle.ukm.my/5983/ http://journalarticle.ukm.my/5983/ http://journalarticle.ukm.my/5983/1/15%2520Hazli%2520Zakaria.pdf

id	ukm-5983
recordtype	eprints
spelling	ukm-59832016-12-14T06:40:01Z http://journalarticle.ukm.my/5983/ Motor neurological soft signs among patients with schizophrenia: a clinical significance Hazli Zakaria, Nik Ruzyanei Nik Jaafar, Azlin Baharuddin, Normala Ibrahim, Marhani Midin, Neurological soft signs (NSS) are subtle indicators of brain dysfunction which are present in excess among patients with schizophrenia. Its clinical significance remains unclear despite extensive researches in this area. The objective of this work was to determine the proportion of Schizophrenia patients who have motor NSS and then to compare the clinical features between these two groups; with and without motor NSS. This cross-sectional study which utilized the brief motor scale (BMS) was used to investigate the presence of motor NSS in 80 schizophrenia patients who attended Universiti Kebangsaan Malaysia Medical Centre (UKMCC) Psychiatric clinic. The diagnosis of Schizophrenia was confirmed by mini international neuropsychiatic interview (MINI). Symptomatology and abnormal motor movement were assessed using the brief psychiatric rating scale (BPRS) and abnormal involuntary movement scale (AIMS), respectively. A brief battery of cognitive tests covering aspects of attention, working memory and executive function was administered. The bivariate analyses were applied to look for any relationship between the study factors. Majority of schizophrenia patients (68.8%) in this study have motor NSS. The motor NSS were associated with ethnic group, level of education, age of onset, duration of illness and performance in cognitive assessment; verbal fluency, digit span forward, digit span backward and trail making B (p<0.05) but not with trail making A. The assessment of motor NSS represents a brief, inexpensive and meaningful tool in assessing the cognitive functions in schizophrenia. It has the potential as an illness marker and a link between neurobiological research and clinical practice. Universiti Kebangsaan Malaysia 2013-03 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5983/1/15%2520Hazli%2520Zakaria.pdf Hazli Zakaria, and Nik Ruzyanei Nik Jaafar, and Azlin Baharuddin, and Normala Ibrahim, and Marhani Midin, (2013) Motor neurological soft signs among patients with schizophrenia: a clinical significance. Sains Malaysiana, 42 (3). pp. 381-388. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Neurological soft signs (NSS) are subtle indicators of brain dysfunction which are present in excess among patients with schizophrenia. Its clinical significance remains unclear despite extensive researches in this area. The objective of this work was to determine the proportion of Schizophrenia patients who have motor NSS and then to compare the clinical features between these two groups; with and without motor NSS. This cross-sectional study which utilized the brief motor scale (BMS) was used to investigate the presence of motor NSS in 80 schizophrenia patients who attended Universiti Kebangsaan Malaysia Medical Centre (UKMCC) Psychiatric clinic. The diagnosis of Schizophrenia was confirmed by mini international neuropsychiatic interview (MINI). Symptomatology and abnormal motor movement were assessed using the brief psychiatric rating scale (BPRS) and abnormal involuntary movement scale (AIMS), respectively. A brief battery of cognitive tests covering aspects of attention, working memory and executive function was administered. The bivariate analyses were applied to look for any relationship between the study factors. Majority of schizophrenia patients (68.8%) in this study have motor NSS. The motor NSS were associated with ethnic group, level of education, age of onset, duration of illness and performance in cognitive assessment; verbal fluency, digit span forward, digit span backward and trail making B (p<0.05) but not with trail making A. The assessment of motor NSS represents a brief, inexpensive and meaningful tool in assessing the cognitive functions in schizophrenia. It has the potential as an illness marker and a link between neurobiological research and clinical practice.
format	Article
author	Hazli Zakaria, Nik Ruzyanei Nik Jaafar, Azlin Baharuddin, Normala Ibrahim, Marhani Midin,
spellingShingle	Hazli Zakaria, Nik Ruzyanei Nik Jaafar, Azlin Baharuddin, Normala Ibrahim, Marhani Midin, Motor neurological soft signs among patients with schizophrenia: a clinical significance
author_facet	Hazli Zakaria, Nik Ruzyanei Nik Jaafar, Azlin Baharuddin, Normala Ibrahim, Marhani Midin,
author_sort	Hazli Zakaria,
title	Motor neurological soft signs among patients with schizophrenia: a clinical significance
title_short	Motor neurological soft signs among patients with schizophrenia: a clinical significance
title_full	Motor neurological soft signs among patients with schizophrenia: a clinical significance
title_fullStr	Motor neurological soft signs among patients with schizophrenia: a clinical significance
title_full_unstemmed	Motor neurological soft signs among patients with schizophrenia: a clinical significance
title_sort	motor neurological soft signs among patients with schizophrenia: a clinical significance
publisher	Universiti Kebangsaan Malaysia
publishDate	2013
url	http://journalarticle.ukm.my/5983/ http://journalarticle.ukm.my/5983/ http://journalarticle.ukm.my/5983/1/15%2520Hazli%2520Zakaria.pdf
first_indexed	2023-09-18T19:45:40Z
last_indexed	2023-09-18T19:45:40Z
_version_	1777405883230191616

Motor neurological soft signs among patients with schizophrenia: a clinical significance

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