‘Emergency chemotherapy’ for bleeding cervical cancer: case series

Fulminant haemorrhage in cervical cancer leads to severe anaemia and haemodynamic instability. Palliative management includes vaginal packing as temporary measure, radiotherapy and other invasive surgical procedures. High dose emergency chemotherapy is not commonly implemented particularly when comp...

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Main Authors:	Shafiee, MN, NorAzlin, MI, Lim, PS, Trika, I, Arifuddin, D, Hatta, D
Format:	Article
Language:	English
Published:	Department of Surgery, UKM Medical Centre 2012
Online Access:	http://journalarticle.ukm.my/5942/ http://journalarticle.ukm.my/5942/ http://journalarticle.ukm.my/5942/1/09-MS1066_%2835-37%29_1.pdf

id	ukm-5942
recordtype	eprints
spelling	ukm-59422016-12-14T06:39:55Z http://journalarticle.ukm.my/5942/ ‘Emergency chemotherapy’ for bleeding cervical cancer: case series Shafiee, MN NorAzlin, MI Lim, PS Trika, I Arifuddin, D Hatta, D Fulminant haemorrhage in cervical cancer leads to severe anaemia and haemodynamic instability. Palliative management includes vaginal packing as temporary measure, radiotherapy and other invasive surgical procedures. High dose emergency chemotherapy is not commonly implemented particularly when complicated with anaemia and renal impairment. We discuss three case series on the usefulness of high dose chemotherapy to combat bleeding from cervical cancer as an emergency treatment. The first case was clinically staged as operable 2A disease with severe anaemia due to bleeding from the tumour mass. The haemoglobin was corrected by blood transfusion while the bleeding was being arrested by high dose chemotherapy. The second case was inoperable with invasion to the bladder mucosa. She had frank haematuria and bleeding from the tumour with severe anaemia. A course of chemotherapy and blood transfusion controlled the bleeding and anaemia was corrected. The third case presented late with obstructive uropathy and anaemia. She required dialysis, blood transfusion and high dose emergency chemotherapy to stop the bleeding before undergoing urinary diversion after an unsuccessful ureteric stenting. High dose chemotherapy consisting cisplatin, vincristine, bleomycin and mitomycin-C has a clinical value in arresting fulminant haemorrhage in cervical cancer. Department of Surgery, UKM Medical Centre 2012 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5942/1/09-MS1066_%2835-37%29_1.pdf Shafiee, MN and NorAzlin, MI and Lim, PS and Trika, I and Arifuddin, D and Hatta, D (2012) ‘Emergency chemotherapy’ for bleeding cervical cancer: case series. Journal of Surgical Academia, 2 (2). pp. 35-37. ISSN 2231-7481 http://jsurgacad.com/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Fulminant haemorrhage in cervical cancer leads to severe anaemia and haemodynamic instability. Palliative management includes vaginal packing as temporary measure, radiotherapy and other invasive surgical procedures. High dose emergency chemotherapy is not commonly implemented particularly when complicated with anaemia and renal impairment. We discuss three case series on the usefulness of high dose chemotherapy to combat bleeding from cervical cancer as an emergency treatment. The first case was clinically staged as operable 2A disease with severe anaemia due to bleeding from the tumour mass. The haemoglobin was corrected by blood transfusion while the bleeding was being arrested by high dose chemotherapy. The second case was inoperable with invasion to the bladder mucosa. She had frank haematuria and bleeding from the tumour with severe anaemia. A course of chemotherapy and blood transfusion controlled the bleeding and anaemia was corrected. The third case presented late with obstructive uropathy and anaemia. She required dialysis, blood transfusion and high dose emergency chemotherapy to stop the bleeding before undergoing urinary diversion after an unsuccessful ureteric stenting. High dose chemotherapy consisting cisplatin, vincristine, bleomycin and mitomycin-C has a clinical value in arresting fulminant haemorrhage in cervical cancer.
format	Article
author	Shafiee, MN NorAzlin, MI Lim, PS Trika, I Arifuddin, D Hatta, D
spellingShingle	Shafiee, MN NorAzlin, MI Lim, PS Trika, I Arifuddin, D Hatta, D ‘Emergency chemotherapy’ for bleeding cervical cancer: case series
author_facet	Shafiee, MN NorAzlin, MI Lim, PS Trika, I Arifuddin, D Hatta, D
author_sort	Shafiee, MN
title	‘Emergency chemotherapy’ for bleeding cervical cancer: case series
title_short	‘Emergency chemotherapy’ for bleeding cervical cancer: case series
title_full	‘Emergency chemotherapy’ for bleeding cervical cancer: case series
title_fullStr	‘Emergency chemotherapy’ for bleeding cervical cancer: case series
title_full_unstemmed	‘Emergency chemotherapy’ for bleeding cervical cancer: case series
title_sort	‘emergency chemotherapy’ for bleeding cervical cancer: case series
publisher	Department of Surgery, UKM Medical Centre
publishDate	2012
url	http://journalarticle.ukm.my/5942/ http://journalarticle.ukm.my/5942/ http://journalarticle.ukm.my/5942/1/09-MS1066_%2835-37%29_1.pdf
first_indexed	2023-09-18T19:45:33Z
last_indexed	2023-09-18T19:45:33Z
_version_	1777405876119797760

‘Emergency chemotherapy’ for bleeding cervical cancer: case series

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