The role of reactive oxygen species in pressure-dependent myogenic tone

Myogenic tone is the response of the vascular smooth muscle to an increase in intraluminal pressure with vasoconstriction and with vasodilation when the pressure is decreased. Such myogenic tone contributes a level of physiological basal tone in response to neurohumoral stimuli. In spite of myogenic...

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Main Authors:	Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth
Format:	Article
Language:	English
Published:	penerbit ukm 2012
Subjects:	RA Public aspects of medicine
Online Access:	http://journalarticle.ukm.my/5611/ http://journalarticle.ukm.my/5611/1/JSKM%20bab%201.pdf

id	ukm-5611
recordtype	eprints
spelling	ukm-56112016-12-14T06:38:59Z http://journalarticle.ukm.my/5611/ The role of reactive oxygen species in pressure-dependent myogenic tone Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth, RA Public aspects of medicine Myogenic tone is the response of the vascular smooth muscle to an increase in intraluminal pressure with vasoconstriction and with vasodilation when the pressure is decreased. Such myogenic tone contributes a level of physiological basal tone in response to neurohumoral stimuli. In spite of myogenic tone discovery by Sir William Bayliss 100 years ago, questions still remain regarding the underlying signaling mechanism of the myogenic response. Studies have shown that increased intraluminal pressure or wall tension leads to membrane depolarization, voltage-operated calcium channel (VOCC), stretch-activated cation (SAC) channels, extracelullar matrix (ECM) and actin cytoskeleton. Recently, evidence has shown a potential role for reactive oxygen species (ROS) as a key signalling mediator in the genesis of myogenic tone. The identification of the primary mechanosensors in the initiation of pressure-dependent myogenic tone is essential as these components could be potential therapeutical targets in the future. penerbit ukm 2012 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5611/1/JSKM%20bab%201.pdf Satirah Zainalabidin, and Paul Coats, and Roger M. Wadsworth, (2012) The role of reactive oxygen species in pressure-dependent myogenic tone. Jurnal Sains Kesihatan Malaysia, 10 (1). pp. 1-11. ISSN 1675-8161
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
topic	RA Public aspects of medicine
spellingShingle	RA Public aspects of medicine Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth, The role of reactive oxygen species in pressure-dependent myogenic tone
description	Myogenic tone is the response of the vascular smooth muscle to an increase in intraluminal pressure with vasoconstriction and with vasodilation when the pressure is decreased. Such myogenic tone contributes a level of physiological basal tone in response to neurohumoral stimuli. In spite of myogenic tone discovery by Sir William Bayliss 100 years ago, questions still remain regarding the underlying signaling mechanism of the myogenic response. Studies have shown that increased intraluminal pressure or wall tension leads to membrane depolarization, voltage-operated calcium channel (VOCC), stretch-activated cation (SAC) channels, extracelullar matrix (ECM) and actin cytoskeleton. Recently, evidence has shown a potential role for reactive oxygen species (ROS) as a key signalling mediator in the genesis of myogenic tone. The identification of the primary mechanosensors in the initiation of pressure-dependent myogenic tone is essential as these components could be potential therapeutical targets in the future.
format	Article
author	Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth,
author_facet	Satirah Zainalabidin, Paul Coats, Roger M. Wadsworth,
author_sort	Satirah Zainalabidin,
title	The role of reactive oxygen species in pressure-dependent myogenic tone
title_short	The role of reactive oxygen species in pressure-dependent myogenic tone
title_full	The role of reactive oxygen species in pressure-dependent myogenic tone
title_fullStr	The role of reactive oxygen species in pressure-dependent myogenic tone
title_full_unstemmed	The role of reactive oxygen species in pressure-dependent myogenic tone
title_sort	role of reactive oxygen species in pressure-dependent myogenic tone
publisher	penerbit ukm
publishDate	2012
url	http://journalarticle.ukm.my/5611/ http://journalarticle.ukm.my/5611/1/JSKM%20bab%201.pdf
first_indexed	2023-09-18T19:44:37Z
last_indexed	2023-09-18T19:44:37Z
_version_	1777405817346064384

The role of reactive oxygen species in pressure-dependent myogenic tone

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