Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre

Many challenges arise in candidaemia treatment which involves emergence of antifungal resistance. New species have been identified due to improved methods of detection and some are resistant to commonly prescribed antifungal agents such as fluconazole and amphotericin B. Therefore, the objective of...

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Main Authors:	Siti Umairah Hamid, Sharon Tan, Siti Nurwani Ahmad Ridzuan, Mohd Syazwan Che Seman, Ramliza Ramli, Tzar Mohd Nizam Khaithir
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2012
Online Access:	http://journalarticle.ukm.my/5417/ http://journalarticle.ukm.my/5417/ http://journalarticle.ukm.my/5417/1/04%2520Siti%2520Umairah.pdf

id	ukm-5417
recordtype	eprints
spelling	ukm-54172016-12-14T06:38:23Z http://journalarticle.ukm.my/5417/ Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre Siti Umairah Hamid, Sharon Tan, Siti Nurwani Ahmad Ridzuan, Mohd Syazwan Che Seman, Ramliza Ramli, Tzar Mohd Nizam Khaithir, Many challenges arise in candidaemia treatment which involves emergence of antifungal resistance. New species have been identified due to improved methods of detection and some are resistant to commonly prescribed antifungal agents such as fluconazole and amphotericin B. Therefore, the objective of the study was to observe any changes in the susceptibility patterns and distribution of Candida species. This cross sectional study was conducted at the Department of Medical Microbiology and Immunology in UKMMC, a tertiary teaching hospital. One hundred and fifty one data were collected from the department’s laboratory records from January 2008 to December 2010. The yeasts were identified using ID32C carbohydrate assimilation tests whilst the antifungal susceptibility test was performed using Sensititre® YeastOne® broth microdilution method. Antifungal agents tested included amphotericin B, fluconazole, itraconazole, voriconazole, 5-flucytosine and caspofungin. Out of 151 blood isolates, 47 (31.1%) were Candida albicans and 104 (68.9%) were non-albicans Candida species. Candida tropicalis has surpassed C. albicans as the most commonly isolated Candida species from blood. Overall susceptibility (as compared to 2005-2006 data in brackets) to caspofungin was 99.3% (n/a), 5-flucytosine 97.4% (98%), amphotericin B 94.7% (100%), voriconazole 92.7% (98%), fluconazole 86.8% (90%) and itraconazole 39.1% (40%). In conclusion, although the isolates were generally still susceptible to amphotericin B and fluconazole, resistance to these drugs is increasing. Universiti Kebangsaan Malaysia 2012-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5417/1/04%2520Siti%2520Umairah.pdf Siti Umairah Hamid, and Sharon Tan, and Siti Nurwani Ahmad Ridzuan, and Mohd Syazwan Che Seman, and Ramliza Ramli, and Tzar Mohd Nizam Khaithir, (2012) Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre. Sains Malaysiana, 41 (8). pp. 961-967. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Many challenges arise in candidaemia treatment which involves emergence of antifungal resistance. New species have been identified due to improved methods of detection and some are resistant to commonly prescribed antifungal agents such as fluconazole and amphotericin B. Therefore, the objective of the study was to observe any changes in the susceptibility patterns and distribution of Candida species. This cross sectional study was conducted at the Department of Medical Microbiology and Immunology in UKMMC, a tertiary teaching hospital. One hundred and fifty one data were collected from the department’s laboratory records from January 2008 to December 2010. The yeasts were identified using ID32C carbohydrate assimilation tests whilst the antifungal susceptibility test was performed using Sensititre® YeastOne® broth microdilution method. Antifungal agents tested included amphotericin B, fluconazole, itraconazole, voriconazole, 5-flucytosine and caspofungin. Out of 151 blood isolates, 47 (31.1%) were Candida albicans and 104 (68.9%) were non-albicans Candida species. Candida tropicalis has surpassed C. albicans as the most commonly isolated Candida species from blood. Overall susceptibility (as compared to 2005-2006 data in brackets) to caspofungin was 99.3% (n/a), 5-flucytosine 97.4% (98%), amphotericin B 94.7% (100%), voriconazole 92.7% (98%), fluconazole 86.8% (90%) and itraconazole 39.1% (40%). In conclusion, although the isolates were generally still susceptible to amphotericin B and fluconazole, resistance to these drugs is increasing.
format	Article
author	Siti Umairah Hamid, Sharon Tan, Siti Nurwani Ahmad Ridzuan, Mohd Syazwan Che Seman, Ramliza Ramli, Tzar Mohd Nizam Khaithir,
spellingShingle	Siti Umairah Hamid, Sharon Tan, Siti Nurwani Ahmad Ridzuan, Mohd Syazwan Che Seman, Ramliza Ramli, Tzar Mohd Nizam Khaithir, Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre
author_facet	Siti Umairah Hamid, Sharon Tan, Siti Nurwani Ahmad Ridzuan, Mohd Syazwan Che Seman, Ramliza Ramli, Tzar Mohd Nizam Khaithir,
author_sort	Siti Umairah Hamid,
title	Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre
title_short	Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre
title_full	Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre
title_fullStr	Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre
title_full_unstemmed	Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre
title_sort	antifungal susceptibility patterns among candida species isolated from blood at universiti kebangsaan malaysia medical centre
publisher	Universiti Kebangsaan Malaysia
publishDate	2012
url	http://journalarticle.ukm.my/5417/ http://journalarticle.ukm.my/5417/ http://journalarticle.ukm.my/5417/1/04%2520Siti%2520Umairah.pdf
first_indexed	2023-09-18T19:44:03Z
last_indexed	2023-09-18T19:44:03Z
_version_	1777405781458550784

Antifungal susceptibility patterns among candida species isolated from blood at Universiti Kebangsaan Malaysia Medical Centre

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