Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis?

Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis?

Formation of arterio-venous-fistulae (AVF) may exacerbate cardiac failure in the ever increasing, elderly population on haemodialysis. Brain Natriuretic Peptide (BNP) may prove a useful marker of cardiac failure in this population. We aimed to determine effect of creation of an AVF and flow in AVF o...

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Main Authors: Suttie, Stuart A, Mofidi, Reza, Bagul, Anil, Babber, Adarsh, Coats, Maria, Ross, Rose, Steedman, Scott, Levison, Rosie, Severn, Alison, Howd, Alison, Struthers, Alan, Nagy, Janos, Griffiths, Gareth D
Format: Article
Language:English
Published: Department of Surgery, UKM Medical Centre 2012
Subjects:
RB Pathology
Online Access:http://journalarticle.ukm.my/5170/
http://journalarticle.ukm.my/5170/
http://journalarticle.ukm.my/5170/1/02-MS1044%282-7%29.pdf
id ukm-5170
recordtype eprints
spelling ukm-51702016-12-14T06:37:47Z http://journalarticle.ukm.my/5170/ Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis? Suttie, Stuart A Mofidi, Reza Bagul, Anil Babber, Adarsh Coats, Maria Ross, Rose Steedman, Scott Levison, Rosie Severn, Alison Howd, Alison Struthers, Alan Nagy, Janos Griffiths, Gareth D RB Pathology Formation of arterio-venous-fistulae (AVF) may exacerbate cardiac failure in the ever increasing, elderly population on haemodialysis. Brain Natriuretic Peptide (BNP) may prove a useful marker of cardiac failure in this population. We aimed to determine effect of creation of an AVF and flow in AVF on BNP levels. Ten patients undergoing primary formation of an upper limb autologous AVF (pre-dialysis), were recruited. Serum BNP (pg/ml) and flow in AVF (cm3/s) were documented pre-operatively, and then 2, 6 and 12 weeks post-operatively. The relationship between flow and BNP levels was assessed. Ten patients (6 male), mean age of 66yrs were recruited. Five patients had a radio-cephalic and 5 had a brachio-cephalic AVF formed. There was no correlation between BNP levels and flow within the AVF (r=0.34, p=0.28) at any time point. There was a general trend towards increased flow in the AVF over time, with only the change between flow at 2-weeks and 3-months postoperatively reaching significance, p=0.043. There was a general trend for BNP to fall over time in the postoperative period, with no significant change between the postoperative sampling time points. BNP levels do not correlate with flow across an AVF. Department of Surgery, UKM Medical Centre 2012-03-15 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5170/1/02-MS1044%282-7%29.pdf Suttie, Stuart A and Mofidi, Reza and Bagul, Anil and Babber, Adarsh and Coats, Maria and Ross, Rose and Steedman, Scott and Levison, Rosie and Severn, Alison and Howd, Alison and Struthers, Alan and Nagy, Janos and Griffiths, Gareth D (2012) Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis? Journal of Surgical Academia, 2 (1). pp. 2-7. ISSN 2231-7481 http://jsurgacad.com/
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
topic RB Pathology
spellingShingle RB Pathology
Suttie, Stuart A
Mofidi, Reza
Bagul, Anil
Babber, Adarsh
Coats, Maria
Ross, Rose
Steedman, Scott
Levison, Rosie
Severn, Alison
Howd, Alison
Struthers, Alan
Nagy, Janos
Griffiths, Gareth D
Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis?
description Formation of arterio-venous-fistulae (AVF) may exacerbate cardiac failure in the ever increasing, elderly population on haemodialysis. Brain Natriuretic Peptide (BNP) may prove a useful marker of cardiac failure in this population. We aimed to determine effect of creation of an AVF and flow in AVF on BNP levels. Ten patients undergoing primary formation of an upper limb autologous AVF (pre-dialysis), were recruited. Serum BNP (pg/ml) and flow in AVF (cm3/s) were documented pre-operatively, and then 2, 6 and 12 weeks post-operatively. The relationship between flow and BNP levels was assessed. Ten patients (6 male), mean age of 66yrs were recruited. Five patients had a radio-cephalic and 5 had a brachio-cephalic AVF formed. There was no correlation between BNP levels and flow within the AVF (r=0.34, p=0.28) at any time point. There was a general trend towards increased flow in the AVF over time, with only the change between flow at 2-weeks and 3-months postoperatively reaching significance, p=0.043. There was a general trend for BNP to fall over time in the postoperative period, with no significant change between the postoperative sampling time points. BNP levels do not correlate with flow across an AVF.
format Article
author Suttie, Stuart A
Mofidi, Reza
Bagul, Anil
Babber, Adarsh
Coats, Maria
Ross, Rose
Steedman, Scott
Levison, Rosie
Severn, Alison
Howd, Alison
Struthers, Alan
Nagy, Janos
Griffiths, Gareth D
author_facet Suttie, Stuart A
Mofidi, Reza
Bagul, Anil
Babber, Adarsh
Coats, Maria
Ross, Rose
Steedman, Scott
Levison, Rosie
Severn, Alison
Howd, Alison
Struthers, Alan
Nagy, Janos
Griffiths, Gareth D
author_sort Suttie, Stuart A
title Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis?
title_short Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis?
title_full Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis?
title_fullStr Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis?
title_full_unstemmed Are Brain Natriuretic Peptide Levels Related to Flow through Autologous Aterio-Venous Fistulae for Chronic Haemodialysis?
title_sort are brain natriuretic peptide levels related to flow through autologous aterio-venous fistulae for chronic haemodialysis?
publisher Department of Surgery, UKM Medical Centre
publishDate 2012
url http://journalarticle.ukm.my/5170/
http://journalarticle.ukm.my/5170/
http://journalarticle.ukm.my/5170/1/02-MS1044%282-7%29.pdf
first_indexed 2023-09-18T19:43:30Z
last_indexed 2023-09-18T19:43:30Z
_version_ 1777405746875465728

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