Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats

Curcuma longa or turmeric has long been used in traditional medicine by the local population in Malaysia as an antiinflammatory agent. It has been proven to contain natural antiarthritic compound called curcumin. Joints abnormality and destruction have been implicated in the pathogenesis of rheumato...

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Main Authors:	Zahidah, A.F, Faizah, O, Nur Aqilah, K, Taty Anna, K
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2012
Online Access:	http://journalarticle.ukm.my/4472/ http://journalarticle.ukm.my/4472/ http://journalarticle.ukm.my/4472/1/10%2520Zahidah.pdf

id	ukm-4472
recordtype	eprints
spelling	ukm-44722016-12-14T06:36:07Z http://journalarticle.ukm.my/4472/ Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats Zahidah, A.F Faizah, O Nur Aqilah, K Taty Anna, K Curcuma longa or turmeric has long been used in traditional medicine by the local population in Malaysia as an antiinflammatory agent. It has been proven to contain natural antiarthritic compound called curcumin. Joints abnormality and destruction have been implicated in the pathogenesis of rheumatoid arthritis (RA) due to inflammatory reactions. In this study, collagen-induced arthritis (CIA) model was utilized to study the effects of curcumin on joint inflammation in Sprague-Dawley rats. Body weight measurement, arthritis score assessment and radiology score assessment were carried out at specific intervals throughout this study. The results showed that the mean arthritis and radiology scores for animal groups designated as CIA CurcuminC and CIA CurcuminT were significantly lower compared with the negative control (CIA OV) group respectively. The mean arthritis scores for CIA CurcuminC group is significantly lower compared with CIA CurcuminT group but there is no significant difference in the mean radiology scores between the CIA CurcuminC and CIA CurcuminT groups. In conclusion, the oral supplementation of curcumin at the dose of 110 mg/mL/kg/day has a potential to delay and improve joint abnormality and injury in Sprague-Dawley rats with CIA. Universiti Kebangsaan Malaysia 2012-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/4472/1/10%2520Zahidah.pdf Zahidah, A.F and Faizah, O and Nur Aqilah, K and Taty Anna, K (2012) Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats. Sains Malaysiana, 41 (5). pp. 591-595. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Curcuma longa or turmeric has long been used in traditional medicine by the local population in Malaysia as an antiinflammatory agent. It has been proven to contain natural antiarthritic compound called curcumin. Joints abnormality and destruction have been implicated in the pathogenesis of rheumatoid arthritis (RA) due to inflammatory reactions. In this study, collagen-induced arthritis (CIA) model was utilized to study the effects of curcumin on joint inflammation in Sprague-Dawley rats. Body weight measurement, arthritis score assessment and radiology score assessment were carried out at specific intervals throughout this study. The results showed that the mean arthritis and radiology scores for animal groups designated as CIA CurcuminC and CIA CurcuminT were significantly lower compared with the negative control (CIA OV) group respectively. The mean arthritis scores for CIA CurcuminC group is significantly lower compared with CIA CurcuminT group but there is no significant difference in the mean radiology scores between the CIA CurcuminC and CIA CurcuminT groups. In conclusion, the oral supplementation of curcumin at the dose of 110 mg/mL/kg/day has a potential to delay and improve joint abnormality and injury in Sprague-Dawley rats with CIA.
format	Article
author	Zahidah, A.F Faizah, O Nur Aqilah, K Taty Anna, K
spellingShingle	Zahidah, A.F Faizah, O Nur Aqilah, K Taty Anna, K Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
author_facet	Zahidah, A.F Faizah, O Nur Aqilah, K Taty Anna, K
author_sort	Zahidah, A.F
title	Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_short	Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_full	Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_fullStr	Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_full_unstemmed	Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
title_sort	curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats
publisher	Universiti Kebangsaan Malaysia
publishDate	2012
url	http://journalarticle.ukm.my/4472/ http://journalarticle.ukm.my/4472/ http://journalarticle.ukm.my/4472/1/10%2520Zahidah.pdf
first_indexed	2023-09-18T19:41:38Z
last_indexed	2023-09-18T19:41:38Z
_version_	1777405629489479680

Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats

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