Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties

There has been an increasing interest in the use of natural materials as drug delivery vehicles due to their biodegradability, biocompatibility and ready availability. These properties make bacterial cellulose (BC), from nata de coco, a promising biopolymer for drug delivery applications. The aim of...

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Main Authors:	Mohd Cairul Iqbal Mohd Amin, Abadi Gumah Abadi, Naveed Ahmad, Haliza Katas, Jamia Azdina Jamal
Format:	Article
Language:	English
Published:	Universiti Kebangsaan Malaysia 2012
Online Access:	http://journalarticle.ukm.my/4468/ http://journalarticle.ukm.my/4468/ http://journalarticle.ukm.my/4468/1/06%2520Mohammad%2520Cairul.pdf

id	ukm-4468
recordtype	eprints
spelling	ukm-44682016-12-14T06:36:06Z http://journalarticle.ukm.my/4468/ Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties Mohd Cairul Iqbal Mohd Amin, Abadi Gumah Abadi, Naveed Ahmad, Haliza Katas, Jamia Azdina Jamal, There has been an increasing interest in the use of natural materials as drug delivery vehicles due to their biodegradability, biocompatibility and ready availability. These properties make bacterial cellulose (BC), from nata de coco, a promising biopolymer for drug delivery applications. The aim of this study was to investigate the film-coating and drug release properties of this biopolymer. Physicochemical, morphological and thermal properties of BC films were studied. Model tablets were film coated with BC, using a spray coating technique, and in vitro drug release studies of these tablets were investigated. It was found that BC exhibited excellent ability to form soft, flexible and foldable films without the addition of any plasticizer. They were comparable to AquacoatECD (with plasticizer) in tensile strength, percentage elongation and elasticity modulus. Differential scanning calorimetry (DSC) BC showed a high Tg value indicating thermally stability of films. These results suggest that BC can be used as novel aqueous film-coating agent with lower cost and better film forming properties than existing film-coating agents. Universiti Kebangsaan Malaysia 2012-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/4468/1/06%2520Mohammad%2520Cairul.pdf Mohd Cairul Iqbal Mohd Amin, and Abadi Gumah Abadi, and Naveed Ahmad, and Haliza Katas, and Jamia Azdina Jamal, (2012) Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties. Sains Malaysiana, 41 (5). pp. 561-568. ISSN 0126-6039 http://www.ukm.my/jsm/
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	There has been an increasing interest in the use of natural materials as drug delivery vehicles due to their biodegradability, biocompatibility and ready availability. These properties make bacterial cellulose (BC), from nata de coco, a promising biopolymer for drug delivery applications. The aim of this study was to investigate the film-coating and drug release properties of this biopolymer. Physicochemical, morphological and thermal properties of BC films were studied. Model tablets were film coated with BC, using a spray coating technique, and in vitro drug release studies of these tablets were investigated. It was found that BC exhibited excellent ability to form soft, flexible and foldable films without the addition of any plasticizer. They were comparable to AquacoatECD (with plasticizer) in tensile strength, percentage elongation and elasticity modulus. Differential scanning calorimetry (DSC) BC showed a high Tg value indicating thermally stability of films. These results suggest that BC can be used as novel aqueous film-coating agent with lower cost and better film forming properties than existing film-coating agents.
format	Article
author	Mohd Cairul Iqbal Mohd Amin, Abadi Gumah Abadi, Naveed Ahmad, Haliza Katas, Jamia Azdina Jamal,
spellingShingle	Mohd Cairul Iqbal Mohd Amin, Abadi Gumah Abadi, Naveed Ahmad, Haliza Katas, Jamia Azdina Jamal, Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties
author_facet	Mohd Cairul Iqbal Mohd Amin, Abadi Gumah Abadi, Naveed Ahmad, Haliza Katas, Jamia Azdina Jamal,
author_sort	Mohd Cairul Iqbal Mohd Amin,
title	Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties
title_short	Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties
title_full	Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties
title_fullStr	Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties
title_full_unstemmed	Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties
title_sort	bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties
publisher	Universiti Kebangsaan Malaysia
publishDate	2012
url	http://journalarticle.ukm.my/4468/ http://journalarticle.ukm.my/4468/ http://journalarticle.ukm.my/4468/1/06%2520Mohammad%2520Cairul.pdf
first_indexed	2023-09-18T19:41:38Z
last_indexed	2023-09-18T19:41:38Z
_version_	1777405628918005760

Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties

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