Effects of lindane as an endocrine disruptor chemical on human health

Over the past decades, a number of substances in the environment have been detected to have detrimental effects on the endocrine system. These substances have been labeled as endocrine disruptor chemicals (EDC) as they mimic or block hormones function and therefore, disrupt the normal body physiolog...

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Main Authors:	Rozita, H., Hasni, M.J
Format:	Article
Language:	English
Published:	Department Of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia 2005
Online Access:	http://journalarticle.ukm.my/4457/ http://journalarticle.ukm.my/4457/ http://journalarticle.ukm.my/4457/1/vol11-02ayiesah.pdf

id	ukm-4457
recordtype	eprints
spelling	ukm-44572016-12-14T06:36:04Z http://journalarticle.ukm.my/4457/ Effects of lindane as an endocrine disruptor chemical on human health Rozita, H., Hasni, M.J, Over the past decades, a number of substances in the environment have been detected to have detrimental effects on the endocrine system. These substances have been labeled as endocrine disruptor chemicals (EDC) as they mimic or block hormones function and therefore, disrupt the normal body physiological functions. Effects on human beings include decrease in sperm counts and quality, cryptorchidism, hypospadias, testicular and male breast cancer,impairment of ovulatory mechanism and cardiovascular system. One of the examples of these EDC is lindane, a 99% pure gamma isomer of hexachlorocyclo-hexane. Exposures to lindane are either through dermal contact, inhalation or ingestion. Acute toxicity symptoms include headache, gastrointestinal symptoms, convulsion, cyanosis and circulatory collapse. Chronic symptoms include blood disorders, convulsion and disruption of the endocrine system particularly the reproductive system. Lindane has also been anticipated as a carcinogen. The International Agency for Research in Cancer (1991) has classified lindane as Class 2B carcinogen. The United States Environmental Protection Agency (USEPA) has set a maximum contaminant level of 0.2 parts per billion (ppb) in drinking water. Acceptable daily intake (ADI) for lindane by Codex Alimentarius is 0.001 mg / kg body weight per day. Due to its endocrine disruptor characteristic and carcinogen effects, there is a need for a rapid elimination of lindane usage in the pharmaceutical, veterinary and agricultural today. We also need an effective delivery of education programme about the risk of lindane, emphasizing the protection of exposed groups of children, indigenous people and workers. Department Of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia 2005 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/4457/1/vol11-02ayiesah.pdf Rozita, H., and Hasni, M.J, (2005) Effects of lindane as an endocrine disruptor chemical on human health. Jurnal Kesihatan Masyarakat, 11 (1). pp. 51-55. ISSN 1675-1663 http://www.communityhealthjournal.org/detailarticle.asp?id=340&issue=Vol11(1):2005
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Over the past decades, a number of substances in the environment have been detected to have detrimental effects on the endocrine system. These substances have been labeled as endocrine disruptor chemicals (EDC) as they mimic or block hormones function and therefore, disrupt the normal body physiological functions. Effects on human beings include decrease in sperm counts and quality, cryptorchidism, hypospadias, testicular and male breast cancer,impairment of ovulatory mechanism and cardiovascular system. One of the examples of these EDC is lindane, a 99% pure gamma isomer of hexachlorocyclo-hexane. Exposures to lindane are either through dermal contact, inhalation or ingestion. Acute toxicity symptoms include headache, gastrointestinal symptoms, convulsion, cyanosis and circulatory collapse. Chronic symptoms include blood disorders, convulsion and disruption of the endocrine system particularly the reproductive system. Lindane has also been anticipated as a carcinogen. The International Agency for Research in Cancer (1991) has classified lindane as Class 2B carcinogen. The United States Environmental Protection Agency (USEPA) has set a maximum contaminant level of 0.2 parts per billion (ppb) in drinking water. Acceptable daily intake (ADI) for lindane by Codex Alimentarius is 0.001 mg / kg body weight per day. Due to its endocrine disruptor characteristic and carcinogen effects, there is a need for a rapid elimination of lindane usage in the pharmaceutical, veterinary and agricultural today. We also need an effective delivery of education programme about the risk of lindane, emphasizing the protection of exposed groups of children, indigenous people and workers.
format	Article
author	Rozita, H., Hasni, M.J,
spellingShingle	Rozita, H., Hasni, M.J, Effects of lindane as an endocrine disruptor chemical on human health
author_facet	Rozita, H., Hasni, M.J,
author_sort	Rozita, H.,
title	Effects of lindane as an endocrine disruptor chemical on human health
title_short	Effects of lindane as an endocrine disruptor chemical on human health
title_full	Effects of lindane as an endocrine disruptor chemical on human health
title_fullStr	Effects of lindane as an endocrine disruptor chemical on human health
title_full_unstemmed	Effects of lindane as an endocrine disruptor chemical on human health
title_sort	effects of lindane as an endocrine disruptor chemical on human health
publisher	Department Of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia
publishDate	2005
url	http://journalarticle.ukm.my/4457/ http://journalarticle.ukm.my/4457/ http://journalarticle.ukm.my/4457/1/vol11-02ayiesah.pdf
first_indexed	2023-09-18T19:41:36Z
last_indexed	2023-09-18T19:41:36Z
_version_	1777405627302150144

Effects of lindane as an endocrine disruptor chemical on human health

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