Hip structure associated with hip fracture in women data from the Geelong Osteoporosis Study (GOS)
Aging leads to changes in bones to be highly fragile causing fractures. In this research, changes in the dimensions of the hip structure can be measured by using a computer program called ‘Hip Structural Analysis (HSA)’. The objective of this study is to estimate the association between hip geom...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Kebangsaan Malaysia
2011
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| Online Access: | http://journalarticle.ukm.my/3553/ http://journalarticle.ukm.my/3553/ http://journalarticle.ukm.my/3553/1/special%2520issue%25202011_26.pdf |
| Summary: | Aging leads to changes in bones to be highly fragile causing fractures.
In this research, changes in the dimensions of the hip structure can be
measured by using a computer program called ‘Hip Structural Analysis
(HSA)’. The objective of this study is to estimate the association
between hip geometries in Femoral Neck (FN) and the risk of hip
fracture in older women.A case control study was performed to explore the objective
respectively using the data of participants from population cohort and
fracture cohort of the Geelong Osteoporosis Cohort Geelong, Southern
Victoria, Australia. Simple and multiple logistic regressions were
performed.Of total of 598, comparing Fracture group (44 subjects) and nonfracture
group (454 subjects) aged over 63 years, the odds of hip
fracture increased by approximately 2 fold for each 1 SD increase in
width (OR=1.70(1.18-2.45,p 0.005), endocortical diameter (OR=1.80
(1,23-2.62, p=0.002), and buckling ratio (OR=1.85(1.32- 2.61, p <
0.0001) and for each 1 SD decrease in BMD (OR=1.98(1.21-3.23,
p.0.006) and average cortical thickness (OR=2.02(1.23-3.34), p.0.006)
controlling for age, height, weight and menopausal status. Findings
suggest that not only is BMD associated with hip fractures, but also
other hip geometry dimensions, including WID, ENDO, AVCO and
AVBR, independent of age, height, weight and physical activity.These results provide additional insights that the geometries of FN is
associated with fracture neck of femur in older women and strongly
suggest its potential value, not only BMD, as clinical predictors for
assessing the risk of hip fracture in older women. In addition to this,
utilization of some combined parameters of bone geometries in FN
might be a more effective method in screening than case findings to
reduce the burden of hip fracture in the future. Further statistical
methods is needed to analyze the combined hip structure to predict hip
fracture |
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