Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls

Glutathione S-transferases (GST) are antioxidant enzymes that play an important role in the cellular detoxification and excretion of environmental pollutants including heavy metals. GST mu (GSTM1) and G theta (GSTT1) are known to be highly polymorphic and homozygous deletions of these genes result...

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Main Authors:	Donna Hermawati, Then, Sue-Mian, Tri Indah Winarni, Sultana MH Faradz, Rahman Jamal
Format:	Article
Language:	English
Published:	UKM Medical Molecular biology Institute, UMBI 2011
Online Access:	http://journalarticle.ukm.my/3062/ http://journalarticle.ukm.my/3062/ http://journalarticle.ukm.my/3062/1/2011-1-2.pdf

id	ukm-3062
recordtype	eprints
spelling	ukm-30622016-12-14T06:33:28Z http://journalarticle.ukm.my/3062/ Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls Donna Hermawati, Then, Sue-Mian Tri Indah Winarni, Sultana MH Faradz, Rahman Jamal, Glutathione S-transferases (GST) are antioxidant enzymes that play an important role in the cellular detoxification and excretion of environmental pollutants including heavy metals. GST mu (GSTM1) and G theta (GSTT1) are known to be highly polymorphic and homozygous deletions of these genes result in the lack of enzyme activity and when combined with decreased levels of antioxidants, they have been associated with the Autism Spectrum Disorder (ASD). This preliminary study was performed to investigate the role of GSTM1 and GSTT1 polymorphisms as risk factors of ASD associated with GST activity and phenotype expression. Fifty one ASD patients and 45 controls were recruited for GSTM1 and GSTT1 genotyping while 6 ASD patients and 8 controls were assessed for GST activity. The results showed no significant differences in frequencies of GSTM1 null, GSTT1 null and combination both genotype between ASD patients and controls. However the mean erythrocyte GST activity in ASD is significantly decreased compared with controls (p = 0.043). The mean erythrocyte GST activity is lower in the severely autistic group compare to the mild to moderately autistic group, although it was not statistically significant. Further investigations are needed with a bigger sample size, analyzing multiple GST genes and GST activity determination to find out the gene susceptibility of ASD and factors that contribute to the phenotype expression of ASD. UKM Medical Molecular biology Institute, UMBI 2011 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/3062/1/2011-1-2.pdf Donna Hermawati, and Then, Sue-Mian and Tri Indah Winarni, and Sultana MH Faradz, and Rahman Jamal, (2011) Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls. Asia-Pacific Journal of Molecular medicine, 1 . pp. 1-6. ISSN 2232-0326 http://www.umbi.ukm.my/umbi/index.php?option=com_content&task=view&id=388&Itemid=72
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Glutathione S-transferases (GST) are antioxidant enzymes that play an important role in the cellular detoxification and excretion of environmental pollutants including heavy metals. GST mu (GSTM1) and G theta (GSTT1) are known to be highly polymorphic and homozygous deletions of these genes result in the lack of enzyme activity and when combined with decreased levels of antioxidants, they have been associated with the Autism Spectrum Disorder (ASD). This preliminary study was performed to investigate the role of GSTM1 and GSTT1 polymorphisms as risk factors of ASD associated with GST activity and phenotype expression. Fifty one ASD patients and 45 controls were recruited for GSTM1 and GSTT1 genotyping while 6 ASD patients and 8 controls were assessed for GST activity. The results showed no significant differences in frequencies of GSTM1 null, GSTT1 null and combination both genotype between ASD patients and controls. However the mean erythrocyte GST activity in ASD is significantly decreased compared with controls (p = 0.043). The mean erythrocyte GST activity is lower in the severely autistic group compare to the mild to moderately autistic group, although it was not statistically significant. Further investigations are needed with a bigger sample size, analyzing multiple GST genes and GST activity determination to find out the gene susceptibility of ASD and factors that contribute to the phenotype expression of ASD.
format	Article
author	Donna Hermawati, Then, Sue-Mian Tri Indah Winarni, Sultana MH Faradz, Rahman Jamal,
spellingShingle	Donna Hermawati, Then, Sue-Mian Tri Indah Winarni, Sultana MH Faradz, Rahman Jamal, Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls
author_facet	Donna Hermawati, Then, Sue-Mian Tri Indah Winarni, Sultana MH Faradz, Rahman Jamal,
author_sort	Donna Hermawati,
title	Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls
title_short	Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls
title_full	Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls
title_fullStr	Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls
title_full_unstemmed	Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls
title_sort	lower erythrocyte gst activity in autism spectrum disorder (asd) patients compared to normal controls
publisher	UKM Medical Molecular biology Institute, UMBI
publishDate	2011
url	http://journalarticle.ukm.my/3062/ http://journalarticle.ukm.my/3062/ http://journalarticle.ukm.my/3062/1/2011-1-2.pdf
first_indexed	2023-09-18T19:37:46Z
last_indexed	2023-09-18T19:37:46Z
_version_	1777405385822437376

Lower Erythrocyte GST activity in Autism Spectrum Disorder (ASD) patients compared to normal controls

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