Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population

The folate and methionine metabolism play essential roles in DNA synthesis and DNA methylation, hence their metabolic pathways might affect the susceptibility to diseases such as leukaemia. In this study, we examined the frequencies of several folate-related genes polymorphisms such as methylenete...

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Main Authors:	Siti Norfaizah Wagiman, Noor Hamidah Husin, Zarina Abd Latiff, Hamidah Alias, Rahman Jamal, Syed Zulkifli Syed Zakaria
Format:	Article
Language:	English
Published:	Penerbit UKM 2011
Online Access:	http://journalarticle.ukm.my/3041/ http://journalarticle.ukm.my/3041/ http://journalarticle.ukm.my/3041/1/01ADNAN_JUSOH.pdf

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recordtype	eprints
spelling	ukm-30412016-12-14T06:33:24Z http://journalarticle.ukm.my/3041/ Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population Siti Norfaizah Wagiman, Noor Hamidah Husin, Zarina Abd Latiff, Hamidah Alias, Rahman Jamal, Syed Zulkifli Syed Zakaria, The folate and methionine metabolism play essential roles in DNA synthesis and DNA methylation, hence their metabolic pathways might affect the susceptibility to diseases such as leukaemia. In this study, we examined the frequencies of several folate-related genes polymorphisms such as methylenetetrahydrofolate reductase MTHFR C677T and A1298C, methylenetetrahydrofolate dehydrogenase1 MTHFD1 G1958A, methionine synthase MTR A2756G and reduced folate carrier RFC1 G80A in 131 childhood leukaemia patients using PCR and PCR-RFLP techniques and determined their association with the risk of developing childhood leukaemia. An increased occurrence of childhood leukaemia was associated with MTHFR 677 CT (OR = 7.22; 95 % CI, 2.98-17.50), MTHFR 1298 AC (OR: 27.92 95% CI: 9.89-78.83) and MTHFR 1298 CC (OR: 13.25 95% CI: 4.42-39.73), RFC1 80 GA (OR: 3.95 95% CI: 1.58-9.83), RFC1 80 AA (OR: 3.83, 95% CI: 1.4-10.26), and SHMT1 1420 CT variant (OR: 5.89, 95% CI: 2.7-12.81) (p < 0.05). On the other hand, MTHFD1 1958 GA (OR = 0.42; 95 % CI, 0.20-0.90; p = 0.03) and MTRR 66 GG variant (OR = 0.05; 95 % CI, 0.01-0.29; p < 0.001) were associated with reduced risk of developing childhood leukaemia. There were no significant association of TS 3R variant and MTR 2576 A > G with the risk of childhood leukaemia variant among the 131 childhood leukaemia patients. Penerbit UKM 2011 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/3041/1/01ADNAN_JUSOH.pdf Siti Norfaizah Wagiman, and Noor Hamidah Husin, and Zarina Abd Latiff, and Hamidah Alias, and Rahman Jamal, and Syed Zulkifli Syed Zakaria, (2011) Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population. Asia-Pacific Journal of Molecular Medicine, 1 . pp. 1-10. ISSN 2232-0326 http://www.umbi.ukm.my/umbi
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The folate and methionine metabolism play essential roles in DNA synthesis and DNA methylation, hence their metabolic pathways might affect the susceptibility to diseases such as leukaemia. In this study, we examined the frequencies of several folate-related genes polymorphisms such as methylenetetrahydrofolate reductase MTHFR C677T and A1298C, methylenetetrahydrofolate dehydrogenase1 MTHFD1 G1958A, methionine synthase MTR A2756G and reduced folate carrier RFC1 G80A in 131 childhood leukaemia patients using PCR and PCR-RFLP techniques and determined their association with the risk of developing childhood leukaemia. An increased occurrence of childhood leukaemia was associated with MTHFR 677 CT (OR = 7.22; 95 % CI, 2.98-17.50), MTHFR 1298 AC (OR: 27.92 95% CI: 9.89-78.83) and MTHFR 1298 CC (OR: 13.25 95% CI: 4.42-39.73), RFC1 80 GA (OR: 3.95 95% CI: 1.58-9.83), RFC1 80 AA (OR: 3.83, 95% CI: 1.4-10.26), and SHMT1 1420 CT variant (OR: 5.89, 95% CI: 2.7-12.81) (p < 0.05). On the other hand, MTHFD1 1958 GA (OR = 0.42; 95 % CI, 0.20-0.90; p = 0.03) and MTRR 66 GG variant (OR = 0.05; 95 % CI, 0.01-0.29; p < 0.001) were associated with reduced risk of developing childhood leukaemia. There were no significant association of TS 3R variant and MTR 2576 A > G with the risk of childhood leukaemia variant among the 131 childhood leukaemia patients.
format	Article
author	Siti Norfaizah Wagiman, Noor Hamidah Husin, Zarina Abd Latiff, Hamidah Alias, Rahman Jamal, Syed Zulkifli Syed Zakaria,
spellingShingle	Siti Norfaizah Wagiman, Noor Hamidah Husin, Zarina Abd Latiff, Hamidah Alias, Rahman Jamal, Syed Zulkifli Syed Zakaria, Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population
author_facet	Siti Norfaizah Wagiman, Noor Hamidah Husin, Zarina Abd Latiff, Hamidah Alias, Rahman Jamal, Syed Zulkifli Syed Zakaria,
author_sort	Siti Norfaizah Wagiman,
title	Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population
title_short	Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population
title_full	Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population
title_fullStr	Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population
title_full_unstemmed	Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population
title_sort	folate-related genes polymorphisms associated with the risk of childhood leukaemia in the malaysian population
publisher	Penerbit UKM
publishDate	2011
url	http://journalarticle.ukm.my/3041/ http://journalarticle.ukm.my/3041/ http://journalarticle.ukm.my/3041/1/01ADNAN_JUSOH.pdf
first_indexed	2023-09-18T19:37:40Z
last_indexed	2023-09-18T19:37:40Z
_version_	1777405380084629504

Folate-related genes polymorphisms associated with the risk of childhood leukaemia in the Malaysian population

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