Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)

The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype. Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a...

Full description

Bibliographic Details
Main Authors:	Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB
Format:	Article
Language:	English
Published:	Penerbit UKM 2010
Online Access:	http://journalarticle.ukm.my/2079/ http://journalarticle.ukm.my/2079/ http://journalarticle.ukm.my/2079/1/08MS090_4144.pdf

id	ukm-2079
recordtype	eprints
spelling	ukm-20792016-12-14T06:30:50Z http://journalarticle.ukm.my/2079/ Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML) Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB, The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype. Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a high incidence of disease relapse. Trisomy 4 is a rare and specific chromosomal abnormality occurring in AML M2 or M4 of the FAB subtypes. We report a case of a 33-year-old female with an apparently clinical and hematologic diagnosis of acute promyelocytic leukemia (APL) in whom cytogenetic analysis revealed an abnormal karyotype with trisomy 4, in addition to t(8;21). Trisomy 4 and t(8;21) in a patient with AML is rare. The significance of t(8;21) with trisomy 4 in AML are unclear but patients bearing this abnormality are associated with a poor prognosis. Penerbit UKM 2010 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2079/1/08MS090_4144.pdf Phan CL, and Ong TC, and Chang KM, and Zubaidah Z, and Puteri Jamilatul NMB, (2010) Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML). Medicine & Health, 5 (1). pp. 45-48. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype. Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a high incidence of disease relapse. Trisomy 4 is a rare and specific chromosomal abnormality occurring in AML M2 or M4 of the FAB subtypes. We report a case of a 33-year-old female with an apparently clinical and hematologic diagnosis of acute promyelocytic leukemia (APL) in whom cytogenetic analysis revealed an abnormal karyotype with trisomy 4, in addition to t(8;21). Trisomy 4 and t(8;21) in a patient with AML is rare. The significance of t(8;21) with trisomy 4 in AML are unclear but patients bearing this abnormality are associated with a poor prognosis.
format	Article
author	Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB,
spellingShingle	Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB, Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)
author_facet	Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB,
author_sort	Phan CL,
title	Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)
title_short	Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)
title_full	Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)
title_fullStr	Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)
title_full_unstemmed	Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)
title_sort	concomitant t(8;21) and trisomy 4 in a patient with acute myeloid leukemia (aml)
publisher	Penerbit UKM
publishDate	2010
url	http://journalarticle.ukm.my/2079/ http://journalarticle.ukm.my/2079/ http://journalarticle.ukm.my/2079/1/08MS090_4144.pdf
first_indexed	2023-09-18T19:35:09Z
last_indexed	2023-09-18T19:35:09Z
_version_	1777405221187616768

Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)

Similar Items