Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study

A cross sectional study was done to determine the prevalence and distribution of human papillomavirus (HPV) genotypes in pre-invasive (cervical intraepithelial neoplasia, grade 3 or CIN 3) and invasive cervical cancer (ICC), in Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A total of 80 p...

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Main Authors:	Sharifa Ezat WP, Sharifah NA, Sayyidi Hamzi AR, Norin Rahayu S
Format:	Article
Language:	English
Published:	Penerbit UKM 2010
Online Access:	http://journalarticle.ukm.my/2071/ http://journalarticle.ukm.my/2071/ http://journalarticle.ukm.my/2071/1/06-MS_084_-_proof__66-76_.pdf

id	ukm-2071
recordtype	eprints
spelling	ukm-20712016-12-14T06:30:49Z http://journalarticle.ukm.my/2071/ Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study Sharifa Ezat WP, Sharifah NA, Sayyidi Hamzi AR, Norin Rahayu S, A cross sectional study was done to determine the prevalence and distribution of human papillomavirus (HPV) genotypes in pre-invasive (cervical intraepithelial neoplasia, grade 3 or CIN 3) and invasive cervical cancer (ICC), in Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A total of 80 paraffin-embedded tumour tissue blocks (20 CIN 3, 60 invasive cancers) between 1999 to 2007 were retrieved from the archives of the Department of Pathology. Patient’s medical records were obtained from the Medical Records Office. Among invasive cancers (n=60), squamous cell carcinoma (SCC) account for 75% and adenocarcinoma 25%. The mean age of cases studied was 52.0 ± 12.2 years and Chinese was the predominant ethnicity (66.3%). Twelve HPV genotypes were identified, namely, HPV 16, 33, 18, 39, 52, 45, 58, 59, 31, 35, 6 and 11. The prevalence of HPV was 92.5% with types 16 being the most common (73.8%), followed by types 33 (30%) and 18 (22.5%). A total of 31 cases (38.8%) showed single HPV genotype, while 43 (53.8%) had multiple HPV (two genotypes or more) genotypes. In ICC, HPV 16, followed by types 33, 18, 52 and 39 were the top five common HPV genotypes detected. High prevalence of HPV and multiple HPV infections were major findings among patients with pre-invasive and invasive cervical cancer Penerbit UKM 2010 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2071/1/06-MS_084_-_proof__66-76_.pdf Sharifa Ezat WP, and Sharifah NA, and Sayyidi Hamzi AR, and Norin Rahayu S, (2010) Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study. Medicine & Health, 5 (2). pp. 66-76. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	A cross sectional study was done to determine the prevalence and distribution of human papillomavirus (HPV) genotypes in pre-invasive (cervical intraepithelial neoplasia, grade 3 or CIN 3) and invasive cervical cancer (ICC), in Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A total of 80 paraffin-embedded tumour tissue blocks (20 CIN 3, 60 invasive cancers) between 1999 to 2007 were retrieved from the archives of the Department of Pathology. Patient’s medical records were obtained from the Medical Records Office. Among invasive cancers (n=60), squamous cell carcinoma (SCC) account for 75% and adenocarcinoma 25%. The mean age of cases studied was 52.0 ± 12.2 years and Chinese was the predominant ethnicity (66.3%). Twelve HPV genotypes were identified, namely, HPV 16, 33, 18, 39, 52, 45, 58, 59, 31, 35, 6 and 11. The prevalence of HPV was 92.5% with types 16 being the most common (73.8%), followed by types 33 (30%) and 18 (22.5%). A total of 31 cases (38.8%) showed single HPV genotype, while 43 (53.8%) had multiple HPV (two genotypes or more) genotypes. In ICC, HPV 16, followed by types 33, 18, 52 and 39 were the top five common HPV genotypes detected. High prevalence of HPV and multiple HPV infections were major findings among patients with pre-invasive and invasive cervical cancer
format	Article
author	Sharifa Ezat WP, Sharifah NA, Sayyidi Hamzi AR, Norin Rahayu S,
spellingShingle	Sharifa Ezat WP, Sharifah NA, Sayyidi Hamzi AR, Norin Rahayu S, Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study
author_facet	Sharifa Ezat WP, Sharifah NA, Sayyidi Hamzi AR, Norin Rahayu S,
author_sort	Sharifa Ezat WP,
title	Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study
title_short	Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study
title_full	Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study
title_fullStr	Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study
title_full_unstemmed	Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study
title_sort	prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-a ukm study
publisher	Penerbit UKM
publishDate	2010
url	http://journalarticle.ukm.my/2071/ http://journalarticle.ukm.my/2071/ http://journalarticle.ukm.my/2071/1/06-MS_084_-_proof__66-76_.pdf
first_indexed	2023-09-18T19:35:08Z
last_indexed	2023-09-18T19:35:08Z
_version_	1777405220023697408

Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study

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