Prevalence of human papillomavirus genotypes in preinvasive and invasive cervical cancer-A UKM study
A cross sectional study was done to determine the prevalence and distribution of human papillomavirus (HPV) genotypes in pre-invasive (cervical intraepithelial neoplasia, grade 3 or CIN 3) and invasive cervical cancer (ICC), in Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A total of 80 p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit UKM
2010
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| Online Access: | http://journalarticle.ukm.my/2071/ http://journalarticle.ukm.my/2071/ http://journalarticle.ukm.my/2071/1/06-MS_084_-_proof__66-76_.pdf |
| Summary: | A cross sectional study was done to determine the prevalence and distribution of
human papillomavirus (HPV) genotypes in pre-invasive (cervical intraepithelial neoplasia, grade 3 or CIN 3) and invasive cervical cancer (ICC), in Universiti
Kebangsaan Malaysia Medical Centre (UKMMC). A total of 80 paraffin-embedded
tumour tissue blocks (20 CIN 3, 60 invasive cancers) between 1999 to 2007 were
retrieved from the archives of the Department of Pathology. Patient’s medical records
were obtained from the Medical Records Office. Among invasive cancers (n=60),
squamous cell carcinoma (SCC) account for 75% and adenocarcinoma 25%. The
mean age of cases studied was 52.0 ± 12.2 years and Chinese was the predominant
ethnicity (66.3%). Twelve HPV genotypes were identified, namely, HPV 16, 33, 18, 39,
52, 45, 58, 59, 31, 35, 6 and 11. The prevalence of HPV was 92.5% with types 16
being the most common (73.8%), followed by types 33 (30%) and 18 (22.5%). A total
of 31 cases (38.8%) showed single HPV genotype, while 43 (53.8%) had multiple HPV
(two genotypes or more) genotypes. In ICC, HPV 16, followed by types 33, 18, 52 and
39 were the top five common HPV genotypes detected. High prevalence of HPV and
multiple HPV infections were major findings among patients with pre-invasive and
invasive cervical cancer |
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