Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats

Oxidative stress has been associated with postmenopausal osteoporosis which pre-disposes to risk of fracture. Palm tocotrienol is a potent antioxidant and has the poten-tial to be used for treatment of post-menopausal osteoporosis. The aim of the study is to determine if palm tocotrienol supplementa...

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Main Authors:	Nazrun AS, Khairunnur A, Norliza M, Norazlina M, Ima Nirwana S
Format:	Article
Language:	English
Published:	Penerbit UKM 2008
Online Access:	http://journalarticle.ukm.my/2027/ http://journalarticle.ukm.my/2027/ http://journalarticle.ukm.my/2027/1/05-247-255_%28MS_056%29.pdf

id	ukm-2027
recordtype	eprints
spelling	ukm-20272016-12-14T06:30:42Z http://journalarticle.ukm.my/2027/ Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats Nazrun AS, Khairunnur A, Norliza M, Norazlina M, Ima Nirwana S, Oxidative stress has been associated with postmenopausal osteoporosis which pre-disposes to risk of fracture. Palm tocotrienol is a potent antioxidant and has the poten-tial to be used for treatment of post-menopausal osteoporosis. The aim of the study is to determine if palm tocotrienol supplementation could alleviate oxidative stress in ovariectomised rat model and improve its bone strength. The rats were di-vided into four groups: (i) sham-operated group (SHAM) (ii) ovariectomised-control group (OVX) (iii) ovariectomised and given 60mg/kg α-tocopherol by oral gavage (OVX + ATF) (iv) ovariectomised and given 60mg/kg palm tocotrienols by oral gavage (OVX + PTT). After eight weeks of treatment, blood samples were taken to measure oxida-tive status (MDA, SOD and GPX) while the femurs were biomechanically tested for strength and resistance to fracture. Ovariectomy was shown to induce oxidative stress as shown by the raised MDA levels and reduced GPX activity. Palm tocotrienols seemed to offer protection against the ovariectomy-induced oxidative stress as shown by the suppression of MDA levels and raised GPX and SOD activities in the OVX+PTT group. In comparison, α-tocopherol was only able to raise the SOD but not as high as palm tocotrienols. The biomechanical tests have shown that ovariectomy has not af-fected the bone strength significantly after eight weeks. Palm tocotrienols supplemen-tation for eight weeks was effective in preventing oxidative stress in a post-meno-pausal rat Penerbit UKM 2008 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2027/1/05-247-255_%28MS_056%29.pdf Nazrun AS, and Khairunnur A, and Norliza M, and Norazlina M, and Ima Nirwana S, (2008) Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats. Medicine & Health, 3 (2). pp. 247-255. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Oxidative stress has been associated with postmenopausal osteoporosis which pre-disposes to risk of fracture. Palm tocotrienol is a potent antioxidant and has the poten-tial to be used for treatment of post-menopausal osteoporosis. The aim of the study is to determine if palm tocotrienol supplementation could alleviate oxidative stress in ovariectomised rat model and improve its bone strength. The rats were di-vided into four groups: (i) sham-operated group (SHAM) (ii) ovariectomised-control group (OVX) (iii) ovariectomised and given 60mg/kg α-tocopherol by oral gavage (OVX + ATF) (iv) ovariectomised and given 60mg/kg palm tocotrienols by oral gavage (OVX + PTT). After eight weeks of treatment, blood samples were taken to measure oxida-tive status (MDA, SOD and GPX) while the femurs were biomechanically tested for strength and resistance to fracture. Ovariectomy was shown to induce oxidative stress as shown by the raised MDA levels and reduced GPX activity. Palm tocotrienols seemed to offer protection against the ovariectomy-induced oxidative stress as shown by the suppression of MDA levels and raised GPX and SOD activities in the OVX+PTT group. In comparison, α-tocopherol was only able to raise the SOD but not as high as palm tocotrienols. The biomechanical tests have shown that ovariectomy has not af-fected the bone strength significantly after eight weeks. Palm tocotrienols supplemen-tation for eight weeks was effective in preventing oxidative stress in a post-meno-pausal rat
format	Article
author	Nazrun AS, Khairunnur A, Norliza M, Norazlina M, Ima Nirwana S,
spellingShingle	Nazrun AS, Khairunnur A, Norliza M, Norazlina M, Ima Nirwana S, Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats
author_facet	Nazrun AS, Khairunnur A, Norliza M, Norazlina M, Ima Nirwana S,
author_sort	Nazrun AS,
title	Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats
title_short	Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats
title_full	Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats
title_fullStr	Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats
title_full_unstemmed	Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats
title_sort	effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats
publisher	Penerbit UKM
publishDate	2008
url	http://journalarticle.ukm.my/2027/ http://journalarticle.ukm.my/2027/ http://journalarticle.ukm.my/2027/1/05-247-255_%28MS_056%29.pdf
first_indexed	2023-09-18T19:34:59Z
last_indexed	2023-09-18T19:34:59Z
_version_	1777405211140161536

Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats

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