Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms

One of the most important cervical cancer risk factors is human papillomavirus (HPV) infection. The p53 gene is one of the most important targets of the HPV E6 gene. E6 protein has the ability to stimulate p53 degradation, inhibits several functions of wild-type p53 and it competes with its funct...

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Main Authors:	Tan GC, Sharifah NA, Salwati S, Hatta AZ, Shiran MS, Ng HO
Format:	Article
Language:	English
Published:	Penerbit UKM 2007
Online Access:	http://journalarticle.ukm.my/1982/ http://journalarticle.ukm.my/1982/ http://journalarticle.ukm.my/1982/1/Page_125-132__MH_053.pdf

id	ukm-1982
recordtype	eprints
spelling	ukm-19822016-12-14T06:30:34Z http://journalarticle.ukm.my/1982/ Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms Tan GC, Sharifah NA, Salwati S, Hatta AZ, Shiran MS, Ng HO, One of the most important cervical cancer risk factors is human papillomavirus (HPV) infection. The p53 gene is one of the most important targets of the HPV E6 gene. E6 protein has the ability to stimulate p53 degradation, inhibits several functions of wild-type p53 and it competes with its function including suppression of malignant growth. The aim of this study is to determine the differences in p53 expressions in pre-malignant and malignant cervical neoplasms. This is a retrospective study on 100 cases of cervical neoplasms. There were 21 cases of CIN 1, 8 cases of CIN 2, 25 cases of CIN 3, 36 cases of squamous cell carcinoma, 7 cases of adenocarcinoma and 3 cases of adenosquamous carcinoma. All cases were evaluated by immunohistochemistry using p53 monoclonal antibody. Thirty six of the 54 pre-malignant cases (66.7%) were positive for p53 protein, in contrast to the malignant cases in which, 40 of the 46 cases (87.0%) were positive. The majority of CIN showed absent to focal staining (29/54, 53.7%). In contrast, 84.8% (39/46) of the invasive carcinoma showed regional to diffuse staining. The expression of p53 is greater in the malignant cervical neoplasms than the pre-malignant cervical lesions, suggesting that p53 overexpression is not an early phenomenon in the pathogenesis of cervical cancer. It is also shown to be slightly higher in percentage in CIN 2 and 3 when compared with CIN 1. However, a number of cases were p53 negative, suggesting that other factors may be involved and further HPV studies are indicated Penerbit UKM 2007 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1982/1/Page_125-132__MH_053.pdf Tan GC, and Sharifah NA, and Salwati S, and Hatta AZ, and Shiran MS, and Ng HO, (2007) Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms. Medicine & Health, 2 (2). pp. 125-132. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	One of the most important cervical cancer risk factors is human papillomavirus (HPV) infection. The p53 gene is one of the most important targets of the HPV E6 gene. E6 protein has the ability to stimulate p53 degradation, inhibits several functions of wild-type p53 and it competes with its function including suppression of malignant growth. The aim of this study is to determine the differences in p53 expressions in pre-malignant and malignant cervical neoplasms. This is a retrospective study on 100 cases of cervical neoplasms. There were 21 cases of CIN 1, 8 cases of CIN 2, 25 cases of CIN 3, 36 cases of squamous cell carcinoma, 7 cases of adenocarcinoma and 3 cases of adenosquamous carcinoma. All cases were evaluated by immunohistochemistry using p53 monoclonal antibody. Thirty six of the 54 pre-malignant cases (66.7%) were positive for p53 protein, in contrast to the malignant cases in which, 40 of the 46 cases (87.0%) were positive. The majority of CIN showed absent to focal staining (29/54, 53.7%). In contrast, 84.8% (39/46) of the invasive carcinoma showed regional to diffuse staining. The expression of p53 is greater in the malignant cervical neoplasms than the pre-malignant cervical lesions, suggesting that p53 overexpression is not an early phenomenon in the pathogenesis of cervical cancer. It is also shown to be slightly higher in percentage in CIN 2 and 3 when compared with CIN 1. However, a number of cases were p53 negative, suggesting that other factors may be involved and further HPV studies are indicated
format	Article
author	Tan GC, Sharifah NA, Salwati S, Hatta AZ, Shiran MS, Ng HO,
spellingShingle	Tan GC, Sharifah NA, Salwati S, Hatta AZ, Shiran MS, Ng HO, Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
author_facet	Tan GC, Sharifah NA, Salwati S, Hatta AZ, Shiran MS, Ng HO,
author_sort	Tan GC,
title	Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
title_short	Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
title_full	Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
title_fullStr	Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
title_full_unstemmed	Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
title_sort	immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
publisher	Penerbit UKM
publishDate	2007
url	http://journalarticle.ukm.my/1982/ http://journalarticle.ukm.my/1982/ http://journalarticle.ukm.my/1982/1/Page_125-132__MH_053.pdf
first_indexed	2023-09-18T19:34:53Z
last_indexed	2023-09-18T19:34:53Z
_version_	1777405204753285120

Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms

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