Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review

Over-expression of P-glycoprotein (P-gp), the encoded product of the ATP-binding cassette (ABC), sub-family B, member 1 (ABCB1/MDR1) gene, plays an important role in mediating multidrug resistance to antiepileptic drugs (AEDs) in about 30% of patients with epilepsy. Genetic variation may in part exp...

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Main Authors:	Haerian BS, Mohamed Z, Mohamed EHM, Lim KS, Tan HJ, Tan CT, Raymond AA
Format:	Article
Language:	English
Published:	Penerbit UKM 2009
Online Access:	http://journalarticle.ukm.my/1938/ http://journalarticle.ukm.my/1938/ http://journalarticle.ukm.my/1938/1/04-4%282%29_~_MS_085_%2864-75%29.pdf

id	ukm-1938
recordtype	eprints
spelling	ukm-19382016-12-14T06:30:29Z http://journalarticle.ukm.my/1938/ Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review Haerian BS, Mohamed Z, Mohamed EHM, Lim KS, Tan HJ, Tan CT, Raymond AA, Over-expression of P-glycoprotein (P-gp), the encoded product of the ATP-binding cassette (ABC), sub-family B, member 1 (ABCB1/MDR1) gene, plays an important role in mediating multidrug resistance to antiepileptic drugs (AEDs) in about 30% of patients with epilepsy. Genetic variation may in part explain inter-individual differences in phenotype-genotype relationships in the pharmacological response of epilepsy patients to AEDs. The synonymous C3435T polymorphism is one of the most common allelic variants in the ABCB1/MDR1 gene, proposed in the causation of refractory epilepsy. Many studies have shown the relationship between C3435T polymorphism and refractoriness to AEDs in epilepsy. However, there is controversy between the findings of various studies, that is, whether ABCB1/MDR1 C3435T gene polymorphism is associated with response to AEDs in epilepsy patients. This review provides a background and discusses the results of investigations on possible confounding factors affecting the interpretation and implementation of association studies in this area. Penerbit UKM 2009 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1938/1/04-4%282%29_~_MS_085_%2864-75%29.pdf Haerian BS, and Mohamed Z, and Mohamed EHM, and Lim KS, and Tan HJ, and Tan CT, and Raymond AA, (2009) Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review. Medicine & Health, 4 (2). pp. 64-75. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Over-expression of P-glycoprotein (P-gp), the encoded product of the ATP-binding cassette (ABC), sub-family B, member 1 (ABCB1/MDR1) gene, plays an important role in mediating multidrug resistance to antiepileptic drugs (AEDs) in about 30% of patients with epilepsy. Genetic variation may in part explain inter-individual differences in phenotype-genotype relationships in the pharmacological response of epilepsy patients to AEDs. The synonymous C3435T polymorphism is one of the most common allelic variants in the ABCB1/MDR1 gene, proposed in the causation of refractory epilepsy. Many studies have shown the relationship between C3435T polymorphism and refractoriness to AEDs in epilepsy. However, there is controversy between the findings of various studies, that is, whether ABCB1/MDR1 C3435T gene polymorphism is associated with response to AEDs in epilepsy patients. This review provides a background and discusses the results of investigations on possible confounding factors affecting the interpretation and implementation of association studies in this area.
format	Article
author	Haerian BS, Mohamed Z, Mohamed EHM, Lim KS, Tan HJ, Tan CT, Raymond AA,
spellingShingle	Haerian BS, Mohamed Z, Mohamed EHM, Lim KS, Tan HJ, Tan CT, Raymond AA, Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review
author_facet	Haerian BS, Mohamed Z, Mohamed EHM, Lim KS, Tan HJ, Tan CT, Raymond AA,
author_sort	Haerian BS,
title	Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review
title_short	Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review
title_full	Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review
title_fullStr	Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review
title_full_unstemmed	Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review
title_sort	role of abcb1 c3435t variant in response to antiepileptic drugs in epilepsy: a review
publisher	Penerbit UKM
publishDate	2009
url	http://journalarticle.ukm.my/1938/ http://journalarticle.ukm.my/1938/ http://journalarticle.ukm.my/1938/1/04-4%282%29_~_MS_085_%2864-75%29.pdf
first_indexed	2023-09-18T19:34:45Z
last_indexed	2023-09-18T19:34:45Z
_version_	1777405195860312064

Role of ABCB1 C3435T variant in response to antiepileptic drugs in epilepsy: a review

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