Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective

Infection by hepatitis B virus (HBV) is a major global health-care problem. HBV is an accepted factor in the elevated risks for liver disease such as cirrhosis and development of hepatocellular carcinoma. This problem is particularly prevalent in the Asia-Pacific region which includes Malaysia. Duri...

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Main Authors:	Chee, Kent Lim, So, Har Ton
Format:	Article
Language:	English
Published:	Penerbit UKM 2007
Online Access:	http://journalarticle.ukm.my/1924/ http://journalarticle.ukm.my/1924/ http://journalarticle.ukm.my/1924/1/01._01-25_%28MH_036%29.pdf

id	ukm-1924
recordtype	eprints
spelling	ukm-19242016-12-14T06:30:27Z http://journalarticle.ukm.my/1924/ Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective Chee, Kent Lim So, Har Ton Infection by hepatitis B virus (HBV) is a major global health-care problem. HBV is an accepted factor in the elevated risks for liver disease such as cirrhosis and development of hepatocellular carcinoma. This problem is particularly prevalent in the Asia-Pacific region which includes Malaysia. During infection, the hepatitis B e antigen (HBeAg) is produced in the hosts. This antigen is an important serological marker for diagnosing chronic hepatitis B. Seroconversion to anti-body (anti-HBe) corresponds to the improvement of disease prognosis. However, certain mutations such as the core promoter dual mutations (A1762G1764→T1762A1764), the codon 15 variants (C1858/ T1858) and the precore stop codon mutations (TGG→TAG) can affect the HBeAg expression. This has diagnostic and clinical implications. Besides that, the HBV can be grouped into eight genotypes (A to H).Moreover, genotypic subtypes and recombinants have been observed as well. Studies have observed that these can differ in their affiliations with the mutations above as well as with disease prognosis Penerbit UKM 2007 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1924/1/01._01-25_%28MH_036%29.pdf Chee, Kent Lim and So, Har Ton (2007) Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective. Medicine & Health, 2 (1). pp. 1-25. ISSN 1823-2140 (In Press) http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Infection by hepatitis B virus (HBV) is a major global health-care problem. HBV is an accepted factor in the elevated risks for liver disease such as cirrhosis and development of hepatocellular carcinoma. This problem is particularly prevalent in the Asia-Pacific region which includes Malaysia. During infection, the hepatitis B e antigen (HBeAg) is produced in the hosts. This antigen is an important serological marker for diagnosing chronic hepatitis B. Seroconversion to anti-body (anti-HBe) corresponds to the improvement of disease prognosis. However, certain mutations such as the core promoter dual mutations (A1762G1764→T1762A1764), the codon 15 variants (C1858/ T1858) and the precore stop codon mutations (TGG→TAG) can affect the HBeAg expression. This has diagnostic and clinical implications. Besides that, the HBV can be grouped into eight genotypes (A to H).Moreover, genotypic subtypes and recombinants have been observed as well. Studies have observed that these can differ in their affiliations with the mutations above as well as with disease prognosis
format	Article
author	Chee, Kent Lim So, Har Ton
spellingShingle	Chee, Kent Lim So, Har Ton Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective
author_facet	Chee, Kent Lim So, Har Ton
author_sort	Chee, Kent Lim
title	Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective
title_short	Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective
title_full	Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective
title_fullStr	Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective
title_full_unstemmed	Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective
title_sort	hepatitis b virus genotypes and mutations affecting hbeag production: a malaysian perspective
publisher	Penerbit UKM
publishDate	2007
url	http://journalarticle.ukm.my/1924/ http://journalarticle.ukm.my/1924/ http://journalarticle.ukm.my/1924/1/01._01-25_%28MH_036%29.pdf
first_indexed	2023-09-18T19:34:43Z
last_indexed	2023-09-18T19:34:43Z
_version_	1777405193763160064

Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective

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