Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy

Myelofibrosis is a chronic myeloproliferative disorder characterised by splenomegaly, leukoerythroblastic anaemia, tear-drop poikilocytosis and marrow fibrosis. Splenectomy is indicated for patients requiring frequent transfusions or massive splenomegaly causing distressing symptoms and severe throm...

Full description

Bibliographic Details
Main Authors:	Chooi-Fun Leong, Soon-Keng Cheong
Format:	Article
Language:	English
Published:	Penerbit UKM 2006
Online Access:	http://journalarticle.ukm.my/1893/ http://journalarticle.ukm.my/1893/ http://journalarticle.ukm.my/1893/1/13._81-84_%28MH_004%29.pdf

id	ukm-1893
recordtype	eprints
spelling	ukm-18932016-12-14T06:30:23Z http://journalarticle.ukm.my/1893/ Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy Chooi-Fun Leong, Soon-Keng Cheong, Myelofibrosis is a chronic myeloproliferative disorder characterised by splenomegaly, leukoerythroblastic anaemia, tear-drop poikilocytosis and marrow fibrosis. Splenectomy is indicated for patients requiring frequent transfusions or massive splenomegaly causing distressing symptoms and severe thrombocytopenia secondary to hypersplenism. A 56 year-old lady diagnosed to have primary myelofibrosis in year 2000 was referred to HUKM for further management of her increasing requirement of blood transfusion and massive splenomegaly. She has had two episodes of acute cholecytitis. Investigations done in our hospital showed that her hemoglobin level was 6.4g/dl, white cell count of 23.4x109/l, platelet count 163x109/l and peripheral blood showing leukoerythroblastic picture and tear-drop poikilocytosis. Leukocyte alkaline phosphatase score (NAP) was 184/100 neutrophils. Ultrasound of the abdomen showed massive splenomegaly with multiple gall stones. In view of the frequent transfusion requirements and symptomatic massive splenomegaly, splenectomy and cholecystectomy was performed. A review of her peripheral blood picture, post-splenectomy, showed marked reduction of the tear-drop poikilocytosis and leukoerythroblastosis. We believe that the spleen plays an important role in their formation, but the exact mechanism remains unclear Penerbit UKM 2006 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1893/1/13._81-84_%28MH_004%29.pdf Chooi-Fun Leong, and Soon-Keng Cheong, (2006) Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy. Medicine & Health, 1 (1). ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Myelofibrosis is a chronic myeloproliferative disorder characterised by splenomegaly, leukoerythroblastic anaemia, tear-drop poikilocytosis and marrow fibrosis. Splenectomy is indicated for patients requiring frequent transfusions or massive splenomegaly causing distressing symptoms and severe thrombocytopenia secondary to hypersplenism. A 56 year-old lady diagnosed to have primary myelofibrosis in year 2000 was referred to HUKM for further management of her increasing requirement of blood transfusion and massive splenomegaly. She has had two episodes of acute cholecytitis. Investigations done in our hospital showed that her hemoglobin level was 6.4g/dl, white cell count of 23.4x109/l, platelet count 163x109/l and peripheral blood showing leukoerythroblastic picture and tear-drop poikilocytosis. Leukocyte alkaline phosphatase score (NAP) was 184/100 neutrophils. Ultrasound of the abdomen showed massive splenomegaly with multiple gall stones. In view of the frequent transfusion requirements and symptomatic massive splenomegaly, splenectomy and cholecystectomy was performed. A review of her peripheral blood picture, post-splenectomy, showed marked reduction of the tear-drop poikilocytosis and leukoerythroblastosis. We believe that the spleen plays an important role in their formation, but the exact mechanism remains unclear
format	Article
author	Chooi-Fun Leong, Soon-Keng Cheong,
spellingShingle	Chooi-Fun Leong, Soon-Keng Cheong, Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy
author_facet	Chooi-Fun Leong, Soon-Keng Cheong,
author_sort	Chooi-Fun Leong,
title	Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy
title_short	Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy
title_full	Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy
title_fullStr	Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy
title_full_unstemmed	Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy
title_sort	reduction of tear-drop poikilocytes in a case of myelofibrosis following splenectomy
publisher	Penerbit UKM
publishDate	2006
url	http://journalarticle.ukm.my/1893/ http://journalarticle.ukm.my/1893/ http://journalarticle.ukm.my/1893/1/13._81-84_%28MH_004%29.pdf
first_indexed	2023-09-18T19:34:39Z
last_indexed	2023-09-18T19:34:39Z
_version_	1777405189477629952

Reduction of Tear-Drop poikilocytes in a case of myelofibrosis following splenectomy

Similar Items