The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model

According to European traditional pharmacopeia, as well as in Chinese traditional medicine, watercress (Nasturtium officinale) has a property in enhancing physical stamina during stress condition. The aim of the study was to evaluate the neuroprotective effects of watercress extract (WCE) on dexamet...

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Main Authors:	Warit Ruanglertboon, Ekkasit Kumarnsit, Sukanya Dej-Adisai, Uraporn Vongvatcharanon, Wandee Udomuksorn
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/14395/ http://journalarticle.ukm.my/14395/ http://journalarticle.ukm.my/14395/1/15%20Warit%20Ruanglertboon.pdf

id	ukm-14395
recordtype	eprints
spelling	ukm-143952020-03-10T02:31:07Z http://journalarticle.ukm.my/14395/ The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model Warit Ruanglertboon, Ekkasit Kumarnsit, Sukanya Dej-Adisai, Uraporn Vongvatcharanon, Wandee Udomuksorn, According to European traditional pharmacopeia, as well as in Chinese traditional medicine, watercress (Nasturtium officinale) has a property in enhancing physical stamina during stress condition. The aim of the study was to evaluate the neuroprotective effects of watercress extract (WCE) on dexamethasone-induced neurodegeneration in mice. Swiss albino male mice (35-40 g) were divided into 6 groups: double distilled water (DW) and normal saline solution (NSS) (DW+NSS), DW and dexamethasone (DW+DEX)-treated for 21 days, 80 mg/kg of watercress extract (WCE) and NSS (80WCE+NSS), and WCE-treated (14 days prior to and during dexamethasone treatment) at variable doses of 20 mg/kg (20WCE+DEX), 40 mg/kg (40WCE+DEX), and 80 mg/kg (80WCE+DEX). At the end of the experiment, animals were tested for spatial memory and learning ability by Morris Water Maze apparatus to determine the escape latency time (ELT), and the density of parvalbumin (PV)-immunoreactive (PV-ir) neurons in the hippocampus of the brain, using immunohistochemistry. After dexamethasone treatment, the animals had significantly lower body weight, higher ELT and reduced density of PV-ir neurons in the CA1 and CA2 regions of the hippocampus, compared to the control animals. These parameters partially improved in animals supplemented with WCE but without a dose-related pattern. This study suggests that WCE may be beneficial for neuroprotection in stress-induced neurodegeneration. Penerbit Universiti Kebangsaan Malaysia 2019-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14395/1/15%20Warit%20Ruanglertboon.pdf Warit Ruanglertboon, and Ekkasit Kumarnsit, and Sukanya Dej-Adisai, and Uraporn Vongvatcharanon, and Wandee Udomuksorn, (2019) The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model. Sains Malaysiana, 48 (10). pp. 2191-2199. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil10_2019/KandunganJilid48Bil10_2019.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	According to European traditional pharmacopeia, as well as in Chinese traditional medicine, watercress (Nasturtium officinale) has a property in enhancing physical stamina during stress condition. The aim of the study was to evaluate the neuroprotective effects of watercress extract (WCE) on dexamethasone-induced neurodegeneration in mice. Swiss albino male mice (35-40 g) were divided into 6 groups: double distilled water (DW) and normal saline solution (NSS) (DW+NSS), DW and dexamethasone (DW+DEX)-treated for 21 days, 80 mg/kg of watercress extract (WCE) and NSS (80WCE+NSS), and WCE-treated (14 days prior to and during dexamethasone treatment) at variable doses of 20 mg/kg (20WCE+DEX), 40 mg/kg (40WCE+DEX), and 80 mg/kg (80WCE+DEX). At the end of the experiment, animals were tested for spatial memory and learning ability by Morris Water Maze apparatus to determine the escape latency time (ELT), and the density of parvalbumin (PV)-immunoreactive (PV-ir) neurons in the hippocampus of the brain, using immunohistochemistry. After dexamethasone treatment, the animals had significantly lower body weight, higher ELT and reduced density of PV-ir neurons in the CA1 and CA2 regions of the hippocampus, compared to the control animals. These parameters partially improved in animals supplemented with WCE but without a dose-related pattern. This study suggests that WCE may be beneficial for neuroprotection in stress-induced neurodegeneration.
format	Article
author	Warit Ruanglertboon, Ekkasit Kumarnsit, Sukanya Dej-Adisai, Uraporn Vongvatcharanon, Wandee Udomuksorn,
spellingShingle	Warit Ruanglertboon, Ekkasit Kumarnsit, Sukanya Dej-Adisai, Uraporn Vongvatcharanon, Wandee Udomuksorn, The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model
author_facet	Warit Ruanglertboon, Ekkasit Kumarnsit, Sukanya Dej-Adisai, Uraporn Vongvatcharanon, Wandee Udomuksorn,
author_sort	Warit Ruanglertboon,
title	The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model
title_short	The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model
title_full	The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model
title_fullStr	The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model
title_full_unstemmed	The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model
title_sort	neuroprotective effect of nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/14395/ http://journalarticle.ukm.my/14395/ http://journalarticle.ukm.my/14395/1/15%20Warit%20Ruanglertboon.pdf
first_indexed	2023-09-18T20:06:58Z
last_indexed	2023-09-18T20:06:58Z
_version_	1777407223675224064

The neuroprotective effect of Nasturtium officinale on learning ability and density of parvalbumin neurons in the hippocampus of neurodegenerative-induced mice model

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