Characterization of the antimicrobial substances produced by Nibribacter radioresistens

This study characterized the antimicrobial substances produced by the radiation-resistant bacterium Nibribacter radioresistens. The antimicrobial substances showed activity against Salmonella Gallinarum, pathogenic Escherichia coli, Bacillus cereus, Streptococcus iniae, and Saccharomyces cerevisiae....

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Main Authors:	Kim, Sam Woong, Ha, Yeon Jo, Gal, Sang Wan, Lee, Kyu Pil, Bang, Kyu Ho, Kang, Myung-Suk, Yeo, Joo-Hong, Yang, Hee-Sun, Jeon, Seung-Ho, Bang, Woo Young
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/14375/ http://journalarticle.ukm.my/14375/ http://journalarticle.ukm.my/14375/1/08%20Sam%20Woong%20Kim.pdf

id	ukm-14375
recordtype	eprints
spelling	ukm-143752020-03-10T02:25:30Z http://journalarticle.ukm.my/14375/ Characterization of the antimicrobial substances produced by Nibribacter radioresistens Kim, Sam Woong Ha, Yeon Jo Gal, Sang Wan Lee, Kyu Pil Bang, Kyu Ho Kang, Myung-Suk Yeo, Joo-Hong Yang, Hee-Sun Jeon, Seung-Ho Bang, Woo Young This study characterized the antimicrobial substances produced by the radiation-resistant bacterium Nibribacter radioresistens. The antimicrobial substances showed activity against Salmonella Gallinarum, pathogenic Escherichia coli, Bacillus cereus, Streptococcus iniae, and Saccharomyces cerevisiae. The substances showed higher activity against Gram-positive bacteria than against Gram-negative bacteria and yeast. N. radioresistens showed the best growth rate in LB liquid medium at 37ºC; however, production of the antimicrobial substances was not associated with growth. Since the activity of the antimicrobial substances was affected by proteinase K and EDTA, the substances were presumed to be antimicrobial peptides (AMPs). The antimicrobial substances produced by N. radioresistens were unstable at higher temperatures and in acidic and basic pH ranges, and most of the activity was attributed to either low (<3 kDa) or high molecular weight (>30 kDa) molecules. When S. Gallinarum was treated with the antimicrobial substances, the cell destruction was acted on the cell envelope. Therefore, we concluded that N. radioresistens produces broad-spectrum and very unstable antimicrobial substances that mostly consist of low- and high-molecular weight peptides. Penerbit Universiti Kebangsaan Malaysia 2019-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14375/1/08%20Sam%20Woong%20Kim.pdf Kim, Sam Woong and Ha, Yeon Jo and Gal, Sang Wan and Lee, Kyu Pil and Bang, Kyu Ho and Kang, Myung-Suk and Yeo, Joo-Hong and Yang, Hee-Sun and Jeon, Seung-Ho and Bang, Woo Young (2019) Characterization of the antimicrobial substances produced by Nibribacter radioresistens. Sains Malaysiana, 48 (10). pp. 2135-2141. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil10_2019/KandunganJilid48Bil10_2019.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	This study characterized the antimicrobial substances produced by the radiation-resistant bacterium Nibribacter radioresistens. The antimicrobial substances showed activity against Salmonella Gallinarum, pathogenic Escherichia coli, Bacillus cereus, Streptococcus iniae, and Saccharomyces cerevisiae. The substances showed higher activity against Gram-positive bacteria than against Gram-negative bacteria and yeast. N. radioresistens showed the best growth rate in LB liquid medium at 37ºC; however, production of the antimicrobial substances was not associated with growth. Since the activity of the antimicrobial substances was affected by proteinase K and EDTA, the substances were presumed to be antimicrobial peptides (AMPs). The antimicrobial substances produced by N. radioresistens were unstable at higher temperatures and in acidic and basic pH ranges, and most of the activity was attributed to either low (<3 kDa) or high molecular weight (>30 kDa) molecules. When S. Gallinarum was treated with the antimicrobial substances, the cell destruction was acted on the cell envelope. Therefore, we concluded that N. radioresistens produces broad-spectrum and very unstable antimicrobial substances that mostly consist of low- and high-molecular weight peptides.
format	Article
author	Kim, Sam Woong Ha, Yeon Jo Gal, Sang Wan Lee, Kyu Pil Bang, Kyu Ho Kang, Myung-Suk Yeo, Joo-Hong Yang, Hee-Sun Jeon, Seung-Ho Bang, Woo Young
spellingShingle	Kim, Sam Woong Ha, Yeon Jo Gal, Sang Wan Lee, Kyu Pil Bang, Kyu Ho Kang, Myung-Suk Yeo, Joo-Hong Yang, Hee-Sun Jeon, Seung-Ho Bang, Woo Young Characterization of the antimicrobial substances produced by Nibribacter radioresistens
author_facet	Kim, Sam Woong Ha, Yeon Jo Gal, Sang Wan Lee, Kyu Pil Bang, Kyu Ho Kang, Myung-Suk Yeo, Joo-Hong Yang, Hee-Sun Jeon, Seung-Ho Bang, Woo Young
author_sort	Kim, Sam Woong
title	Characterization of the antimicrobial substances produced by Nibribacter radioresistens
title_short	Characterization of the antimicrobial substances produced by Nibribacter radioresistens
title_full	Characterization of the antimicrobial substances produced by Nibribacter radioresistens
title_fullStr	Characterization of the antimicrobial substances produced by Nibribacter radioresistens
title_full_unstemmed	Characterization of the antimicrobial substances produced by Nibribacter radioresistens
title_sort	characterization of the antimicrobial substances produced by nibribacter radioresistens
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/14375/ http://journalarticle.ukm.my/14375/ http://journalarticle.ukm.my/14375/1/08%20Sam%20Woong%20Kim.pdf
first_indexed	2023-09-18T20:06:56Z
last_indexed	2023-09-18T20:06:56Z
_version_	1777407221504671744

Characterization of the antimicrobial substances produced by Nibribacter radioresistens

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