Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism

Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism

The incidence of post-menopausal osteoporosis is increasing globally. In post-menopausal osteoporosis, there is deficiency in oestrogen level resulting in bone loss and fractures. Bone formation is under the control of different hormones. In the present review, we highlight few pathways such as RANK...

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Main Authors: Zar, Chi Thent, Srijit Dass, Pasuk Mahakkanukrauh, Lanzotti, Virginia
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:http://journalarticle.ukm.my/14355/
http://journalarticle.ukm.my/14355/
http://journalarticle.ukm.my/14355/1/22%20Srijit%20Das.pdf
id ukm-14355
recordtype eprints
spelling ukm-143552020-03-03T08:06:21Z http://journalarticle.ukm.my/14355/ Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism Zar, Chi Thent Srijit Dass, Pasuk Mahakkanukrauh, Lanzotti, Virginia The incidence of post-menopausal osteoporosis is increasing globally. In post-menopausal osteoporosis, there is deficiency in oestrogen level resulting in bone loss and fractures. Bone formation is under the control of different hormones. In the present review, we highlight few pathways such as RANKL/RANK, apoptosis and Wnt/β-catenin signalling pathways and phytoestrogens involved in the bone metabolism. RANKL/RANK signalling is responsible for regulating the formation and activation of multinucleated osteoclasts from their precursors which is responsible for the survival of normal bone remodelling. Apoptosis regulates the development, growth and maintains the bone tissues. The Wnt pathway is an important pharmacological target for bone anabolic drugs and its future discovery. In today’s world, herbal remedies are used to treat post-menopausal osteoporosis as these products contain phytoestrogens. These phytoestrogens are oestrogen like compounds which influence bone metabolism. The phytoestrogens provide better therapeutic effect in reducing the RANKL, osteoclastogenesis, inflammatory markers, and increase the osteogenic markers in the bone cells or osteoblasts. We discuss the mechanism of action of few phytoestrogens such as genistein, daidzein and equol which are beneficial for improvement of the bone health. Daidzein enhances osteoblast growth via the upregulation of BMP expression in primary osteoblast cells and it is a potential antiosteoporotic agent. Genistein also possesses antioestrogenic property by virtue of its competitive binding to the same receptors as oestradiol. Equol regulates the bone loss via hemopoiesis and inflammatory cytokine production. Thus, phytoestrogens could be efficiently used as osteoprotective agents for the treatment of individuals with post-menopausal osteoporosis. Penerbit Universiti Kebangsaan Malaysia 2019-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14355/1/22%20Srijit%20Das.pdf Zar, Chi Thent and Srijit Dass, and Pasuk Mahakkanukrauh, and Lanzotti, Virginia (2019) Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism. Sains Malaysiana, 48 (9). pp. 2007-2019. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil9_2019/KandunganJilid48Bil9_2019.html
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description The incidence of post-menopausal osteoporosis is increasing globally. In post-menopausal osteoporosis, there is deficiency in oestrogen level resulting in bone loss and fractures. Bone formation is under the control of different hormones. In the present review, we highlight few pathways such as RANKL/RANK, apoptosis and Wnt/β-catenin signalling pathways and phytoestrogens involved in the bone metabolism. RANKL/RANK signalling is responsible for regulating the formation and activation of multinucleated osteoclasts from their precursors which is responsible for the survival of normal bone remodelling. Apoptosis regulates the development, growth and maintains the bone tissues. The Wnt pathway is an important pharmacological target for bone anabolic drugs and its future discovery. In today’s world, herbal remedies are used to treat post-menopausal osteoporosis as these products contain phytoestrogens. These phytoestrogens are oestrogen like compounds which influence bone metabolism. The phytoestrogens provide better therapeutic effect in reducing the RANKL, osteoclastogenesis, inflammatory markers, and increase the osteogenic markers in the bone cells or osteoblasts. We discuss the mechanism of action of few phytoestrogens such as genistein, daidzein and equol which are beneficial for improvement of the bone health. Daidzein enhances osteoblast growth via the upregulation of BMP expression in primary osteoblast cells and it is a potential antiosteoporotic agent. Genistein also possesses antioestrogenic property by virtue of its competitive binding to the same receptors as oestradiol. Equol regulates the bone loss via hemopoiesis and inflammatory cytokine production. Thus, phytoestrogens could be efficiently used as osteoprotective agents for the treatment of individuals with post-menopausal osteoporosis.
format Article
author Zar, Chi Thent
Srijit Dass,
Pasuk Mahakkanukrauh,
Lanzotti, Virginia
spellingShingle Zar, Chi Thent
Srijit Dass,
Pasuk Mahakkanukrauh,
Lanzotti, Virginia
Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism
author_facet Zar, Chi Thent
Srijit Dass,
Pasuk Mahakkanukrauh,
Lanzotti, Virginia
author_sort Zar, Chi Thent
title Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism
title_short Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism
title_full Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism
title_fullStr Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism
title_full_unstemmed Osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism
title_sort osteoporosis: possible pathways involved and the role of natural phytoestrogens in bone metabolism
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2019
url http://journalarticle.ukm.my/14355/
http://journalarticle.ukm.my/14355/
http://journalarticle.ukm.my/14355/1/22%20Srijit%20Das.pdf
first_indexed 2023-09-18T20:06:55Z
last_indexed 2023-09-18T20:06:55Z
_version_ 1777407219515523072

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