Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake

Prediabetes is associated with sugar-sweetened beverages and sugar-rich processed foods. High sugar intake (HSI), which is represented as save dose, may silently alter the glycemic control. The present study investigated the effect of HSI and Tiliacora triandra (TT21) leaf extract on the glycemic co...

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Main Authors:	Wachiryah Thong-asa, Prachayaporn Prasertsuksri, Romgase Sakamula, Theerayut Nimnuan
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/14353/ http://journalarticle.ukm.my/14353/ http://journalarticle.ukm.my/14353/1/20%20Wachiryah%20Thong-asa.pdf

id	ukm-14353
recordtype	eprints
spelling	ukm-143532020-03-03T08:05:23Z http://journalarticle.ukm.my/14353/ Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake Wachiryah Thong-asa, Prachayaporn Prasertsuksri, Romgase Sakamula, Theerayut Nimnuan, Prediabetes is associated with sugar-sweetened beverages and sugar-rich processed foods. High sugar intake (HSI), which is represented as save dose, may silently alter the glycemic control. The present study investigated the effect of HSI and Tiliacora triandra (TT21) leaf extract on the glycemic control in mice. Eighteen male ICR mice were divided into three groups of Control-HSI, HSI-TT300 and HSI-TT600 that received 4 weeks of 30% glucose with a vehicle of T. triandra leaf extract 300 and 600 mg/kg, respectively. The blood glucose, serum insulin, glucose clearance, liver and muscle glycogen contents and tissue oxidative status were evaluated. The results showed that HSI increased the blood glucose (w2 and w3: p<0.05) and serum insulin levels (w3 and w4: p<0.05) with glucose intolerance (w4: 30, 60 and 90 min, p<0.05). T. triandra leaf extract reduced the blood glucose and serum insulin and increased the glycogen content in the liver and muscle tissues (p<0.05). We concluded that HSI silently induced an alteration of the glycemic control in the normal mice, and the T. triandra leaf extract nurtured the glycemic control in the HSI mice by lowering the blood glucose and serum insulin and increasing the liver and muscle glycogen contents, which indicated an involvement of peripheral insulin sensitivity. Penerbit Universiti Kebangsaan Malaysia 2019-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14353/1/20%20Wachiryah%20Thong-asa.pdf Wachiryah Thong-asa, and Prachayaporn Prasertsuksri, and Romgase Sakamula, and Theerayut Nimnuan, (2019) Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake. Sains Malaysiana, 48 (9). pp. 1989-1995. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil9_2019/KandunganJilid48Bil9_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Prediabetes is associated with sugar-sweetened beverages and sugar-rich processed foods. High sugar intake (HSI), which is represented as save dose, may silently alter the glycemic control. The present study investigated the effect of HSI and Tiliacora triandra (TT21) leaf extract on the glycemic control in mice. Eighteen male ICR mice were divided into three groups of Control-HSI, HSI-TT300 and HSI-TT600 that received 4 weeks of 30% glucose with a vehicle of T. triandra leaf extract 300 and 600 mg/kg, respectively. The blood glucose, serum insulin, glucose clearance, liver and muscle glycogen contents and tissue oxidative status were evaluated. The results showed that HSI increased the blood glucose (w2 and w3: p<0.05) and serum insulin levels (w3 and w4: p<0.05) with glucose intolerance (w4: 30, 60 and 90 min, p<0.05). T. triandra leaf extract reduced the blood glucose and serum insulin and increased the glycogen content in the liver and muscle tissues (p<0.05). We concluded that HSI silently induced an alteration of the glycemic control in the normal mice, and the T. triandra leaf extract nurtured the glycemic control in the HSI mice by lowering the blood glucose and serum insulin and increasing the liver and muscle glycogen contents, which indicated an involvement of peripheral insulin sensitivity.
format	Article
author	Wachiryah Thong-asa, Prachayaporn Prasertsuksri, Romgase Sakamula, Theerayut Nimnuan,
spellingShingle	Wachiryah Thong-asa, Prachayaporn Prasertsuksri, Romgase Sakamula, Theerayut Nimnuan, Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake
author_facet	Wachiryah Thong-asa, Prachayaporn Prasertsuksri, Romgase Sakamula, Theerayut Nimnuan,
author_sort	Wachiryah Thong-asa,
title	Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake
title_short	Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake
title_full	Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake
title_fullStr	Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake
title_full_unstemmed	Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake
title_sort	effect of tiliacora triandra leaf extract on glycemic control in mice with high sugar intake
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/14353/ http://journalarticle.ukm.my/14353/ http://journalarticle.ukm.my/14353/1/20%20Wachiryah%20Thong-asa.pdf
first_indexed	2023-09-18T20:06:54Z
last_indexed	2023-09-18T20:06:54Z
_version_	1777407219228213248

Effect of Tiliacora triandra leaf extract on glycemic control in mice with high sugar intake

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