A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair

Comprehensive analysis showed that the popularity of research peripheral blood-derived mesenchymal stem cells for knee cartilage repair is still lacking, as they peripherally exist at a very low level. Despite its small cell number, peripheral blood is yet one of the most convenient sources of mesen...

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Main Authors:	Rufaidah Othman, Chong, Pan Pan, Nahrizul Adib Kadri, Tunku Kamarul
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/14349/ http://journalarticle.ukm.my/14349/ http://journalarticle.ukm.my/14349/1/16%20Rufaidah%20Othman.pdf

id	ukm-14349
recordtype	eprints
spelling	ukm-143492020-03-03T08:03:21Z http://journalarticle.ukm.my/14349/ A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair Rufaidah Othman, Chong, Pan Pan Nahrizul Adib Kadri, Tunku Kamarul, Comprehensive analysis showed that the popularity of research peripheral blood-derived mesenchymal stem cells for knee cartilage repair is still lacking, as they peripherally exist at a very low level. Despite its small cell number, peripheral blood is yet one of the most convenient sources of mesenchymal stem cells due to its less invasive method to harvest. This study aimed to systematically review the current evidence of peripheral blood-derived mesenchymal stem cells towards the repair of articular cartilage defect. A comprehensive literature search was performed to identify all in vivo studies reporting the structural outcome of articular cartilage repair in the knee following electronic databases: PubMed, WOS and SCOPUS. The in vitro characterizations of peripheral blood-derived mesenchymal stem cells were evaluated to enable quality assessment. Literature from 1934 to 2019 showed 4822 of total articles with only three findings related to pre-clinical studies were included in the analysis. The selection of animal model, type of transplantation, mobilization of the peripheral blood, in vitro culture condition, type of scaffold, assessments on the cartilage defect, and the outcome measures were heterogeneous. Evidence showed that mobilized peripheral blood-derived mesenchymal stem cells were more superior in repairing articular cartilage compared to those that were non-mobilized. These cells also showed a comparable capability in repairing articular cartilage than the commonly used bone marrow mesenchymal stem cells. Overall, more progress is needed to expand the usage of peripheral blood-derived mesenchymal stem cells from basic biological science to the translational studies in clinical practice. Penerbit Universiti Kebangsaan Malaysia 2019-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14349/1/16%20Rufaidah%20Othman.pdf Rufaidah Othman, and Chong, Pan Pan and Nahrizul Adib Kadri, and Tunku Kamarul, (2019) A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair. Sains Malaysiana, 48 (9). pp. 1947-1958. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil9_2019/KandunganJilid48Bil9_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Comprehensive analysis showed that the popularity of research peripheral blood-derived mesenchymal stem cells for knee cartilage repair is still lacking, as they peripherally exist at a very low level. Despite its small cell number, peripheral blood is yet one of the most convenient sources of mesenchymal stem cells due to its less invasive method to harvest. This study aimed to systematically review the current evidence of peripheral blood-derived mesenchymal stem cells towards the repair of articular cartilage defect. A comprehensive literature search was performed to identify all in vivo studies reporting the structural outcome of articular cartilage repair in the knee following electronic databases: PubMed, WOS and SCOPUS. The in vitro characterizations of peripheral blood-derived mesenchymal stem cells were evaluated to enable quality assessment. Literature from 1934 to 2019 showed 4822 of total articles with only three findings related to pre-clinical studies were included in the analysis. The selection of animal model, type of transplantation, mobilization of the peripheral blood, in vitro culture condition, type of scaffold, assessments on the cartilage defect, and the outcome measures were heterogeneous. Evidence showed that mobilized peripheral blood-derived mesenchymal stem cells were more superior in repairing articular cartilage compared to those that were non-mobilized. These cells also showed a comparable capability in repairing articular cartilage than the commonly used bone marrow mesenchymal stem cells. Overall, more progress is needed to expand the usage of peripheral blood-derived mesenchymal stem cells from basic biological science to the translational studies in clinical practice.
format	Article
author	Rufaidah Othman, Chong, Pan Pan Nahrizul Adib Kadri, Tunku Kamarul,
spellingShingle	Rufaidah Othman, Chong, Pan Pan Nahrizul Adib Kadri, Tunku Kamarul, A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair
author_facet	Rufaidah Othman, Chong, Pan Pan Nahrizul Adib Kadri, Tunku Kamarul,
author_sort	Rufaidah Othman,
title	A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair
title_short	A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair
title_full	A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair
title_fullStr	A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair
title_full_unstemmed	A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair
title_sort	systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/14349/ http://journalarticle.ukm.my/14349/ http://journalarticle.ukm.my/14349/1/16%20Rufaidah%20Othman.pdf
first_indexed	2023-09-18T20:06:54Z
last_indexed	2023-09-18T20:06:54Z
_version_	1777407218652545024

A systematic review on peripheral blood-derived mesenchymal stem cells as a therapy for cartilage repair

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