The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma

The leaves of cassava are used as traditional medicine, to treat ringworm, tumor, abscess, conjunctivitis, sores, headaches, rheumatism and fever diseases in several countries. Phytochemical investigations showed that flavonoids and Rutin constituents of the cassava leaves, berths the need for data...

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Main Authors:	Nugrahaningsih, WH, Fatimatuz Zahroh, Lisdiana, Ari Yuniastuti, Rudyatmi, Ely
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/13893/ http://journalarticle.ukm.my/13893/ http://journalarticle.ukm.my/13893/1/16%20Nugrahaningsih%20WH.pdf

id	ukm-13893
recordtype	eprints
spelling	ukm-138932020-01-10T08:48:22Z http://journalarticle.ukm.my/13893/ The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma Nugrahaningsih, WH Fatimatuz Zahroh, Lisdiana, Ari Yuniastuti, Rudyatmi, Ely The leaves of cassava are used as traditional medicine, to treat ringworm, tumor, abscess, conjunctivitis, sores, headaches, rheumatism and fever diseases in several countries. Phytochemical investigations showed that flavonoids and Rutin constituents of the cassava leaves, berths the need for data as regards safety, effectiveness, toxicity and pharmacokinetics for its usage as herbal medicine. The purpose of this research was to observe pharmacokinetic parameters of Rutin in rat plasma, after oral administration of cassava leaves extract. Pharmacokinetics indicators for absorption was (Cmax, tmax, and AUC0-24h), while elimination was (Ke and t1/2). 14 healthy male Wistar rats were divided into 7 groups (each group with 2 rats), after which a single dose (600 mg) of cassava leaves extract was given orally. Thereafter, blood samples of the wistar rats were collected and separated at different time intervals (0; 0.5; 1; 2; 4; 6; 12; and 24 h). Using HPLC-UV-VIS method, the resulting plasma was analyzed for Rutin concentration. The analysis showed Rutin concentration at 0 mg/mL (0 h), 0.151 mg/mL (0.5 h), 0.176 mg/mL (1 h), 0.18 mg/mL (2 h), 0.184 mg/mL (4 h), 0.163 mg/mL (6 h), 0.15 mg/mL (12 h) and 0.1225 mg/mL (24 h). The main pharmacokinetic parameters were; Cmax 0.184 mg/mL recorded 4 h (tmax) after oral administration; AUC0-24 was 3.583 mg h/mL and t1/2 was 94.54 h. The study concluded that Rutin of cassava leaves extract, reached maximum concentration within 4 h after oral administration and was inside in the plasma for more than 24 h. Hence, it is recommended to consume cassava leaves extract as herbal medicine, only once a day. Penerbit Universiti Kebangsaan Malaysia 2019-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13893/1/16%20Nugrahaningsih%20WH.pdf Nugrahaningsih, WH and Fatimatuz Zahroh, and Lisdiana, and Ari Yuniastuti, and Rudyatmi, Ely (2019) The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma. Sains Malaysiana, 48 (8). pp. 1707-1712. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil8_2019/KandunganJilid48Bil8_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The leaves of cassava are used as traditional medicine, to treat ringworm, tumor, abscess, conjunctivitis, sores, headaches, rheumatism and fever diseases in several countries. Phytochemical investigations showed that flavonoids and Rutin constituents of the cassava leaves, berths the need for data as regards safety, effectiveness, toxicity and pharmacokinetics for its usage as herbal medicine. The purpose of this research was to observe pharmacokinetic parameters of Rutin in rat plasma, after oral administration of cassava leaves extract. Pharmacokinetics indicators for absorption was (Cmax, tmax, and AUC0-24h), while elimination was (Ke and t1/2). 14 healthy male Wistar rats were divided into 7 groups (each group with 2 rats), after which a single dose (600 mg) of cassava leaves extract was given orally. Thereafter, blood samples of the wistar rats were collected and separated at different time intervals (0; 0.5; 1; 2; 4; 6; 12; and 24 h). Using HPLC-UV-VIS method, the resulting plasma was analyzed for Rutin concentration. The analysis showed Rutin concentration at 0 mg/mL (0 h), 0.151 mg/mL (0.5 h), 0.176 mg/mL (1 h), 0.18 mg/mL (2 h), 0.184 mg/mL (4 h), 0.163 mg/mL (6 h), 0.15 mg/mL (12 h) and 0.1225 mg/mL (24 h). The main pharmacokinetic parameters were; Cmax 0.184 mg/mL recorded 4 h (tmax) after oral administration; AUC0-24 was 3.583 mg h/mL and t1/2 was 94.54 h. The study concluded that Rutin of cassava leaves extract, reached maximum concentration within 4 h after oral administration and was inside in the plasma for more than 24 h. Hence, it is recommended to consume cassava leaves extract as herbal medicine, only once a day.
format	Article
author	Nugrahaningsih, WH Fatimatuz Zahroh, Lisdiana, Ari Yuniastuti, Rudyatmi, Ely
spellingShingle	Nugrahaningsih, WH Fatimatuz Zahroh, Lisdiana, Ari Yuniastuti, Rudyatmi, Ely The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
author_facet	Nugrahaningsih, WH Fatimatuz Zahroh, Lisdiana, Ari Yuniastuti, Rudyatmi, Ely
author_sort	Nugrahaningsih, WH
title	The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_short	The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_full	The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_fullStr	The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_full_unstemmed	The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
title_sort	effect of cassava leaves extract on pharmacokinetics profile of rutin plasma
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/13893/ http://journalarticle.ukm.my/13893/ http://journalarticle.ukm.my/13893/1/16%20Nugrahaningsih%20WH.pdf
first_indexed	2023-09-18T20:05:52Z
last_indexed	2023-09-18T20:05:52Z
_version_	1777407153889345536

The effect of cassava leaves extract on pharmacokinetics profile of rutin plasma

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