Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status

Long chain triglycerides (LCT) from soya oil have been reported to cause hepatic abnormalities among patients receiving parenteral nutrition. A new source for LCT is needed to support current therapy. The aims of this study were to develop a good and stable superolein oil based intravenous lipid emu...

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Main Authors:	Mohd. Haz Hairul Amran, Mohd. Fairuz Danik, Mohd. Shakrie Palan Abdullah, Mohd. Hanif Zulfakar, Ahmad Fuad Shamsuddin
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/13626/ http://journalarticle.ukm.my/13626/ http://journalarticle.ukm.my/13626/1/13%20Mohd.%20Haz%20Hairul%20Amran.pdf

id	ukm-13626
recordtype	eprints
spelling	ukm-136262019-11-10T03:55:34Z http://journalarticle.ukm.my/13626/ Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status Mohd. Haz Hairul Amran, Mohd. Fairuz Danik, Mohd. Shakrie Palan Abdullah, Mohd. Hanif Zulfakar, Ahmad Fuad Shamsuddin, Long chain triglycerides (LCT) from soya oil have been reported to cause hepatic abnormalities among patients receiving parenteral nutrition. A new source for LCT is needed to support current therapy. The aims of this study were to develop a good and stable superolein oil based intravenous lipid emulsion 20% (SoLE), and to determine its effect on liver status of an animal model. The emulsion was prepared using superolein oil and medium chain triglyceride oil (1:1), 1.2 g lecithin and homogenized by high pressure homogenization method. The physical stability study was performed based on real-time, accelerated, force degradation and environmental degradation. Chemical stability was measured based on fatty acids and vitamin E contents, peroxide value and acidity value. As the animal model, three rabbits were administered with 1.5 g/kg SoLE for 5 h and repeated daily for three days. The SoLE was found to have good physicochemical characters: 229.07±1.57 nm of particle size; 0.00% of particle > 5 μm; 342.00±1.00 mOsm/kg of osmolarity; -46.67±4.40 mV of zeta potential; 1.72±0.04 cP of viscosity; 7.83±0.06 of pH; 0.80±0.06 kcal/g calorie; 1.74±0.05 mEqO2/kg of peroxide value; and 0.03±0.01% of acidity value, and excellent physicochemical stabilities for up to six months of storage at various temperatures and conditions. The level of plasma lipid and plasma liver enzymes profiles of the rabbits remained statistically unchanged. This study has successfully developed a stable SoLE 20% and it was found to be safe to the liver of the animal model. Penerbit Universiti Kebangsaan Malaysia 2019-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13626/1/13%20Mohd.%20Haz%20Hairul%20Amran.pdf Mohd. Haz Hairul Amran, and Mohd. Fairuz Danik, and Mohd. Shakrie Palan Abdullah, and Mohd. Hanif Zulfakar, and Ahmad Fuad Shamsuddin, (2019) Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status. Sains Malaysiana, 48 (5). pp. 1043-1054. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil5_2019/KandunganJilid48Bil5_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Long chain triglycerides (LCT) from soya oil have been reported to cause hepatic abnormalities among patients receiving parenteral nutrition. A new source for LCT is needed to support current therapy. The aims of this study were to develop a good and stable superolein oil based intravenous lipid emulsion 20% (SoLE), and to determine its effect on liver status of an animal model. The emulsion was prepared using superolein oil and medium chain triglyceride oil (1:1), 1.2 g lecithin and homogenized by high pressure homogenization method. The physical stability study was performed based on real-time, accelerated, force degradation and environmental degradation. Chemical stability was measured based on fatty acids and vitamin E contents, peroxide value and acidity value. As the animal model, three rabbits were administered with 1.5 g/kg SoLE for 5 h and repeated daily for three days. The SoLE was found to have good physicochemical characters: 229.07±1.57 nm of particle size; 0.00% of particle > 5 μm; 342.00±1.00 mOsm/kg of osmolarity; -46.67±4.40 mV of zeta potential; 1.72±0.04 cP of viscosity; 7.83±0.06 of pH; 0.80±0.06 kcal/g calorie; 1.74±0.05 mEqO2/kg of peroxide value; and 0.03±0.01% of acidity value, and excellent physicochemical stabilities for up to six months of storage at various temperatures and conditions. The level of plasma lipid and plasma liver enzymes profiles of the rabbits remained statistically unchanged. This study has successfully developed a stable SoLE 20% and it was found to be safe to the liver of the animal model.
format	Article
author	Mohd. Haz Hairul Amran, Mohd. Fairuz Danik, Mohd. Shakrie Palan Abdullah, Mohd. Hanif Zulfakar, Ahmad Fuad Shamsuddin,
spellingShingle	Mohd. Haz Hairul Amran, Mohd. Fairuz Danik, Mohd. Shakrie Palan Abdullah, Mohd. Hanif Zulfakar, Ahmad Fuad Shamsuddin, Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status
author_facet	Mohd. Haz Hairul Amran, Mohd. Fairuz Danik, Mohd. Shakrie Palan Abdullah, Mohd. Hanif Zulfakar, Ahmad Fuad Shamsuddin,
author_sort	Mohd. Haz Hairul Amran,
title	Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status
title_short	Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status
title_full	Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status
title_fullStr	Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status
title_full_unstemmed	Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status
title_sort	superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/13626/ http://journalarticle.ukm.my/13626/ http://journalarticle.ukm.my/13626/1/13%20Mohd.%20Haz%20Hairul%20Amran.pdf
first_indexed	2023-09-18T20:05:16Z
last_indexed	2023-09-18T20:05:16Z
_version_	1777407116433162240

Superolein based intravenous lipid emulsion 20% w/w physicochemical characterization, stability and its effect on liver status

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