In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals

Pericampylus glaucus is a common Malaysian plant used traditionally in the treatments of joint pain, abdominal pain and headache. Hence, the present research was aimed to evaluate ethanolic extract of Pericampylus glaucus for analgesic, antipyretic and anti-inflammatory activities in experimental an...

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Main Authors:	Kifayatullah, Muhammad, Rahim, Haroon, Jan, Naeem Ullah, Ahmad Chishti, Kamran, Ullah, Irfan, Abbas, Sudair
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2019
Online Access:	http://journalarticle.ukm.my/13322/ http://journalarticle.ukm.my/13322/ http://journalarticle.ukm.my/13322/1/16%20Muhammad%20Kifayatullah.pdf

id	ukm-13322
recordtype	eprints
spelling	ukm-133222019-08-29T21:39:16Z http://journalarticle.ukm.my/13322/ In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals Kifayatullah, Muhammad Rahim, Haroon Jan, Naeem Ullah Ahmad Chishti, Kamran Ullah, Irfan Abbas, Sudair Pericampylus glaucus is a common Malaysian plant used traditionally in the treatments of joint pain, abdominal pain and headache. Hence, the present research was aimed to evaluate ethanolic extract of Pericampylus glaucus for analgesic, antipyretic and anti-inflammatory activities in experimental animals. The central and peripheral analgesic activity was determined by acetic acid induced writhing and hot plate method by examining the number of writhing and paw licking or jumping time. Meanwhile, the antipyretic activity was determined by Brewer’s yeast- test that induced pyrexia and carrageenan- that induced hind paw inflammation was used for anti-inflammatory activities. The ethanolic extract of Pericampylus glaucus at doses (300 and 600 mg/kg b.wt) and Ibuprofen (100 mg/kg (b.wt) was used as a reference drug in the whole experiment. Intraperitoneal administration of Pericampylus glaucus produced significant (p<0.01) inhibition in writhing response in acetic acid induced writhing test and dose-dependent (p<0.001) prolonged paw licking in hot plate test as compared to control (normal saline treated group). Similarly, significant (p<0.001) attenuation in lowering rectal temperature was noted in animal groups that were treated with ethanolic extract of Pericampylus glaucus at different doses. The attenuation was, almost the same as produced by ibuprofen treated group. Furthermore, Pericampylus glaucus extract also produced significant reduction in hind paw edema (p<0.001), 4 h after administration of carrageenan and inhibition was 60.19% and 42.17% as compared to control (normal saline treated group). The findings of this study indicated that Pericampylus glaucus possess significant analgesic, antipyretic and anti-inflammatory activities and could possibly be used in the management of fever, pain and inflammation. Penerbit Universiti Kebangsaan Malaysia 2019-03 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13322/1/16%20Muhammad%20Kifayatullah.pdf Kifayatullah, Muhammad and Rahim, Haroon and Jan, Naeem Ullah and Ahmad Chishti, Kamran and Ullah, Irfan and Abbas, Sudair (2019) In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals. Sains Malaysiana, 48 (3). pp. 629-635. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil3_2019/KandunganJilid48Bil3_2019.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Pericampylus glaucus is a common Malaysian plant used traditionally in the treatments of joint pain, abdominal pain and headache. Hence, the present research was aimed to evaluate ethanolic extract of Pericampylus glaucus for analgesic, antipyretic and anti-inflammatory activities in experimental animals. The central and peripheral analgesic activity was determined by acetic acid induced writhing and hot plate method by examining the number of writhing and paw licking or jumping time. Meanwhile, the antipyretic activity was determined by Brewer’s yeast- test that induced pyrexia and carrageenan- that induced hind paw inflammation was used for anti-inflammatory activities. The ethanolic extract of Pericampylus glaucus at doses (300 and 600 mg/kg b.wt) and Ibuprofen (100 mg/kg (b.wt) was used as a reference drug in the whole experiment. Intraperitoneal administration of Pericampylus glaucus produced significant (p<0.01) inhibition in writhing response in acetic acid induced writhing test and dose-dependent (p<0.001) prolonged paw licking in hot plate test as compared to control (normal saline treated group). Similarly, significant (p<0.001) attenuation in lowering rectal temperature was noted in animal groups that were treated with ethanolic extract of Pericampylus glaucus at different doses. The attenuation was, almost the same as produced by ibuprofen treated group. Furthermore, Pericampylus glaucus extract also produced significant reduction in hind paw edema (p<0.001), 4 h after administration of carrageenan and inhibition was 60.19% and 42.17% as compared to control (normal saline treated group). The findings of this study indicated that Pericampylus glaucus possess significant analgesic, antipyretic and anti-inflammatory activities and could possibly be used in the management of fever, pain and inflammation.
format	Article
author	Kifayatullah, Muhammad Rahim, Haroon Jan, Naeem Ullah Ahmad Chishti, Kamran Ullah, Irfan Abbas, Sudair
spellingShingle	Kifayatullah, Muhammad Rahim, Haroon Jan, Naeem Ullah Ahmad Chishti, Kamran Ullah, Irfan Abbas, Sudair In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals
author_facet	Kifayatullah, Muhammad Rahim, Haroon Jan, Naeem Ullah Ahmad Chishti, Kamran Ullah, Irfan Abbas, Sudair
author_sort	Kifayatullah, Muhammad
title	In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals
title_short	In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals
title_full	In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals
title_fullStr	In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals
title_full_unstemmed	In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals
title_sort	in vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of pericampylus glaucus in experimental animals
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2019
url	http://journalarticle.ukm.my/13322/ http://journalarticle.ukm.my/13322/ http://journalarticle.ukm.my/13322/1/16%20Muhammad%20Kifayatullah.pdf
first_indexed	2023-09-18T20:04:36Z
last_indexed	2023-09-18T20:04:36Z
_version_	1777407073744584704

In vivo analgesic, antipyretic and anti-inflammatory activities of ethanol extract of Pericampylus glaucus in experimental animals

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