The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population

The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population

Many studies have shown that the immune response highly depends on the inheritance of specific HLA genes in promoting the generation of T cells for the elimination of pathogens. Loss or alteration of HLA antigen expression in tumor cells has been observed in a variety of human malignancies leading t...

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Main Authors: Nor Adzimah Johdi, Sri Noraima Othman, Zuraini Abd Razak, Luqman Mazlan, Ismail Sagap, Rahman Jamal
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2016
Online Access:http://journalarticle.ukm.my/13241/
http://journalarticle.ukm.my/13241/
http://journalarticle.ukm.my/13241/1/30-70-1-SM.pdf
id ukm-13241
recordtype eprints
spelling ukm-132412019-08-02T03:14:29Z http://journalarticle.ukm.my/13241/ The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population Nor Adzimah Johdi, Sri Noraima Othman, Zuraini Abd Razak, Luqman Mazlan, Ismail Sagap, Rahman Jamal, Many studies have shown that the immune response highly depends on the inheritance of specific HLA genes in promoting the generation of T cells for the elimination of pathogens. Loss or alteration of HLA antigen expression in tumor cells has been observed in a variety of human malignancies leading to immune escape or immune resistance. We investigated whether the inheritance of certain alleles of HLA class II genes confers susceptibility or resistance towards the development of colorectal carcinoma (CRC). Molecular typing of HLA DRB1, DQB1 and DPB1 alleles in 42 patients diagnosed with CRC and 50 ethnically matched healthy controls using the PCR-sequence based typing (PCR-SBT) was conducted. The HLA DPB1*02:01:02 was significantly higher in CRC patients (38.1%, p=0.0189) compared to healthy controls (16%). Also, HLA DQB1*05:02:01 was present in 28.6% of CRC patients but only 10% of healthy controls (p=0.0278). The odds ratios for HLA DPB1*02:01:02 and HLA DQB1*05:02:01were 3.23 and 3.60, respectively. There were no significant association observed for the DRB1 allele with CRC. Our study suggests that the HLA DPB1*02:01:02 and HLA DQB1*05:02:01 alleles may confer a higher risk for CRC. Pusat Perubatan Universiti Kebangsaan Malaysia 2016 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/13241/1/30-70-1-SM.pdf Nor Adzimah Johdi, and Sri Noraima Othman, and Zuraini Abd Razak, and Luqman Mazlan, and Ismail Sagap, and Rahman Jamal, (2016) The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population. Asia-Pacific Journal of Molecular Medicine, 6 (2). pp. 1-8. ISSN 2232-0326 http://spaj.ukm.my/apjmm/index.php/apjmm/issue/view/13
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description Many studies have shown that the immune response highly depends on the inheritance of specific HLA genes in promoting the generation of T cells for the elimination of pathogens. Loss or alteration of HLA antigen expression in tumor cells has been observed in a variety of human malignancies leading to immune escape or immune resistance. We investigated whether the inheritance of certain alleles of HLA class II genes confers susceptibility or resistance towards the development of colorectal carcinoma (CRC). Molecular typing of HLA DRB1, DQB1 and DPB1 alleles in 42 patients diagnosed with CRC and 50 ethnically matched healthy controls using the PCR-sequence based typing (PCR-SBT) was conducted. The HLA DPB1*02:01:02 was significantly higher in CRC patients (38.1%, p=0.0189) compared to healthy controls (16%). Also, HLA DQB1*05:02:01 was present in 28.6% of CRC patients but only 10% of healthy controls (p=0.0278). The odds ratios for HLA DPB1*02:01:02 and HLA DQB1*05:02:01were 3.23 and 3.60, respectively. There were no significant association observed for the DRB1 allele with CRC. Our study suggests that the HLA DPB1*02:01:02 and HLA DQB1*05:02:01 alleles may confer a higher risk for CRC.
format Article
author Nor Adzimah Johdi,
Sri Noraima Othman,
Zuraini Abd Razak,
Luqman Mazlan,
Ismail Sagap,
Rahman Jamal,
spellingShingle Nor Adzimah Johdi,
Sri Noraima Othman,
Zuraini Abd Razak,
Luqman Mazlan,
Ismail Sagap,
Rahman Jamal,
The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population
author_facet Nor Adzimah Johdi,
Sri Noraima Othman,
Zuraini Abd Razak,
Luqman Mazlan,
Ismail Sagap,
Rahman Jamal,
author_sort Nor Adzimah Johdi,
title The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population
title_short The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population
title_full The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population
title_fullStr The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population
title_full_unstemmed The HLA DPB1*02:01:02 and DQB1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the Malaysian population
title_sort hla dpb1*02:01:02 and dqb1*05:02:01 alleles as possible risk factors for colorectal carcinoma in the malaysian population
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2016
url http://journalarticle.ukm.my/13241/
http://journalarticle.ukm.my/13241/
http://journalarticle.ukm.my/13241/1/30-70-1-SM.pdf
first_indexed 2023-09-18T20:04:25Z
last_indexed 2023-09-18T20:04:25Z
_version_ 1777407062407380992

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