Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats

Monosodium glutamate (MSG) is widely used as a food additive but its excessive intake leads to oxidative stress of several organs. However, the oxidative effect of MSG on male accessory reproductive organs remains unclear. Therefore, the aim of this study was to evaluate the effect of MSG on the sta...

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Main Authors:	Erni Norfardila Abu Hanipah, Nor Janna Yahya, Esther Mathias Ajik, Nur Afizah Yusoff, Izatus Shima Taib
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12942/ http://journalarticle.ukm.my/12942/ http://journalarticle.ukm.my/12942/1/24017-76981-1-PB.pdf

id	ukm-12942
recordtype	eprints
spelling	ukm-129422019-05-17T14:28:10Z http://journalarticle.ukm.my/12942/ Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats Erni Norfardila Abu Hanipah, Nor Janna Yahya, Esther Mathias Ajik, Nur Afizah Yusoff, Izatus Shima Taib, Monosodium glutamate (MSG) is widely used as a food additive but its excessive intake leads to oxidative stress of several organs. However, the oxidative effect of MSG on male accessory reproductive organs remains unclear. Therefore, the aim of this study was to evaluate the effect of MSG on the status of oxidative stress and morphological alterations in the male accessory reproductive organs such as epididymis, prostate glands and seminal vesicle of Sprague-Dawley rats. A total of 24 male Sprague-Dawley rats were randomly divided into three groups with 8 rats per group. Control group received distilled water (1 ml/kg) while MSG60 and MSG120 received 60 mg/kg and 120 mg/kg of MSG, respectively. All the substances were administered via force feed oral for 28 consecutive days. At the end of the study, the rats were sacrificed to obtain the accessory organs for biochemical analysis and histological observations. The SOD activity in the epididymis showed a significant increase in MSG60 and MSG120 compared to control (p < 0.05). The GSH levels in the epididymis of MSG 120 showed a significant reduction (p < 0.05) compared to the control group. The levels of MDA and PC in the epididymis and prostate gland of MSG60 and MSG120 showed a significant increased (p < 0.05) compared to the control group. Histological alterations were found in the epididymis and prostate gland of MSG treated rats. In conclusion, MSG at both doses induced oxidative stress in the epididymis and prostate gland of experimental rats. Penerbit Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12942/1/24017-76981-1-PB.pdf Erni Norfardila Abu Hanipah, and Nor Janna Yahya, and Esther Mathias Ajik, and Nur Afizah Yusoff, and Izatus Shima Taib, (2018) Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats. Jurnal Sains Kesihatan Malaysia, 16 (SI). pp. 67-73. ISSN 1675-8161 http://ejournal.ukm.my/jskm/issue/view/1072
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Monosodium glutamate (MSG) is widely used as a food additive but its excessive intake leads to oxidative stress of several organs. However, the oxidative effect of MSG on male accessory reproductive organs remains unclear. Therefore, the aim of this study was to evaluate the effect of MSG on the status of oxidative stress and morphological alterations in the male accessory reproductive organs such as epididymis, prostate glands and seminal vesicle of Sprague-Dawley rats. A total of 24 male Sprague-Dawley rats were randomly divided into three groups with 8 rats per group. Control group received distilled water (1 ml/kg) while MSG60 and MSG120 received 60 mg/kg and 120 mg/kg of MSG, respectively. All the substances were administered via force feed oral for 28 consecutive days. At the end of the study, the rats were sacrificed to obtain the accessory organs for biochemical analysis and histological observations. The SOD activity in the epididymis showed a significant increase in MSG60 and MSG120 compared to control (p < 0.05). The GSH levels in the epididymis of MSG 120 showed a significant reduction (p < 0.05) compared to the control group. The levels of MDA and PC in the epididymis and prostate gland of MSG60 and MSG120 showed a significant increased (p < 0.05) compared to the control group. Histological alterations were found in the epididymis and prostate gland of MSG treated rats. In conclusion, MSG at both doses induced oxidative stress in the epididymis and prostate gland of experimental rats.
format	Article
author	Erni Norfardila Abu Hanipah, Nor Janna Yahya, Esther Mathias Ajik, Nur Afizah Yusoff, Izatus Shima Taib,
spellingShingle	Erni Norfardila Abu Hanipah, Nor Janna Yahya, Esther Mathias Ajik, Nur Afizah Yusoff, Izatus Shima Taib, Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats
author_facet	Erni Norfardila Abu Hanipah, Nor Janna Yahya, Esther Mathias Ajik, Nur Afizah Yusoff, Izatus Shima Taib,
author_sort	Erni Norfardila Abu Hanipah,
title	Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats
title_short	Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats
title_full	Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats
title_fullStr	Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats
title_full_unstemmed	Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats
title_sort	monosodium glutamate induced oxidative stress in accessory reproductive organs of male sprague-dawley rats
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12942/ http://journalarticle.ukm.my/12942/ http://journalarticle.ukm.my/12942/1/24017-76981-1-PB.pdf
first_indexed	2023-09-18T20:03:44Z
last_indexed	2023-09-18T20:03:44Z
_version_	1777407019914887168

Monosodium glutamate induced oxidative stress in accessory reproductive organs of male Sprague-Dawley rats

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