Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy

Idiopathic sudden sensorineural hearing loss (ISSNHL) is considered to be an otological emergency. The intratympanic (IT) steroid injection technique is introduced to decrease the side effects of systemic steroids and assumed to deliver a higher concentration of corticosteroids into the affected coc...

Full description

Bibliographic Details
Main Authors:	Ho, Hon Lian, Ruszymah Hj. Idrus, Lokman Saim, Aminuddin Saim
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12659/ http://journalarticle.ukm.my/12659/ http://journalarticle.ukm.my/12659/1/20%20Ho%20Hon%20Lian.pdf

id	ukm-12659
recordtype	eprints
spelling	ukm-126592019-03-17T11:22:44Z http://journalarticle.ukm.my/12659/ Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy Ho, Hon Lian Ruszymah Hj. Idrus, Lokman Saim, Aminuddin Saim, Idiopathic sudden sensorineural hearing loss (ISSNHL) is considered to be an otological emergency. The intratympanic (IT) steroid injection technique is introduced to decrease the side effects of systemic steroids and assumed to deliver a higher concentration of corticosteroids into the affected cochlea. The objective of the current study was to evaluate the hearing outcomes of high dose IT methylprednisolone among ISSNHL patients after failure of systemic corticosteroid therapy (SCT). Hearing outcomes of SCT were evaluated over a 15 months period. Upon failure of SCT, the treatment was continued with higher dose IT steroid (methylprednisolone 62.5 mg/mL). Pre-treatment and post-treatment audiometric evaluations were analysed using pure tone audiogram (PTA). There were 36 patients diagnosed with ISSNHL included in the study. After two weeks of SCT, eighteen (56.3%) patients had hearing improvement of more than 10 dB. Another fourteen (43.7%) patients had no hearing improvement (less than 10 dB). Following that, twelve patients were recruited for weekly IT methylprednisolone for three weeks. During the one month follow up after completion of IT therapy, six patients (50%) showed more than 10 dB improvement in the PTA with a mean of 19.37 dB (p<0.05). Out of the six, two patients had more than 20 dB hearing improvement. Almost all patients in this study had an improvement in their symptoms of tinnitus and vertigo. High dose IT methylprednisolone after failure of SCT resulted in significant improvement in the patients’ hearing outcome during one month follow up. The IT therapy not only improved the patients’ hearing but in addition reduced the symptoms of tinnitus and vertigo. Penerbit Universiti Kebangsaan Malaysia 2018-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12659/1/20%20Ho%20Hon%20Lian.pdf Ho, Hon Lian and Ruszymah Hj. Idrus, and Lokman Saim, and Aminuddin Saim, (2018) Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy. Sains Malaysiana, 47 (11). pp. 2777-2782. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num11_2018/contentsVol47num11_2018.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Idiopathic sudden sensorineural hearing loss (ISSNHL) is considered to be an otological emergency. The intratympanic (IT) steroid injection technique is introduced to decrease the side effects of systemic steroids and assumed to deliver a higher concentration of corticosteroids into the affected cochlea. The objective of the current study was to evaluate the hearing outcomes of high dose IT methylprednisolone among ISSNHL patients after failure of systemic corticosteroid therapy (SCT). Hearing outcomes of SCT were evaluated over a 15 months period. Upon failure of SCT, the treatment was continued with higher dose IT steroid (methylprednisolone 62.5 mg/mL). Pre-treatment and post-treatment audiometric evaluations were analysed using pure tone audiogram (PTA). There were 36 patients diagnosed with ISSNHL included in the study. After two weeks of SCT, eighteen (56.3%) patients had hearing improvement of more than 10 dB. Another fourteen (43.7%) patients had no hearing improvement (less than 10 dB). Following that, twelve patients were recruited for weekly IT methylprednisolone for three weeks. During the one month follow up after completion of IT therapy, six patients (50%) showed more than 10 dB improvement in the PTA with a mean of 19.37 dB (p<0.05). Out of the six, two patients had more than 20 dB hearing improvement. Almost all patients in this study had an improvement in their symptoms of tinnitus and vertigo. High dose IT methylprednisolone after failure of SCT resulted in significant improvement in the patients’ hearing outcome during one month follow up. The IT therapy not only improved the patients’ hearing but in addition reduced the symptoms of tinnitus and vertigo.
format	Article
author	Ho, Hon Lian Ruszymah Hj. Idrus, Lokman Saim, Aminuddin Saim,
spellingShingle	Ho, Hon Lian Ruszymah Hj. Idrus, Lokman Saim, Aminuddin Saim, Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
author_facet	Ho, Hon Lian Ruszymah Hj. Idrus, Lokman Saim, Aminuddin Saim,
author_sort	Ho, Hon Lian
title	Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_short	Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_full	Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_fullStr	Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_full_unstemmed	Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
title_sort	intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12659/ http://journalarticle.ukm.my/12659/ http://journalarticle.ukm.my/12659/1/20%20Ho%20Hon%20Lian.pdf
first_indexed	2023-09-18T20:03:06Z
last_indexed	2023-09-18T20:03:06Z
_version_	1777406979991404544

Intratympanic methylprednisolone injection in idiopathic sudden sensorineural hearing loss after failure of systemic corticosteroid therapy

Similar Items