Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report

Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report

Mycobacterium tuberculosis (MTB) is a rare cause of prosthetic joint infection. The diagnosis is challenging especially in cases of latent tuberculosis. QuantiFERON-TB Gold (QFT®) is an interferon-gamma relative assay (IGRA) which is highly specific and sensitive for detection of MTB infection. We r...

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Main Authors: Norliyana M, Nor Hamdan Mohamad Yahaya, Rizal Abd Rani
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/12553/
http://journalarticle.ukm.my/12553/
http://journalarticle.ukm.my/12553/1/5._norliyana_m_et_al.pdf
id ukm-12553
recordtype eprints
spelling ukm-125532019-02-14T21:29:21Z http://journalarticle.ukm.my/12553/ Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report Norliyana M, Nor Hamdan Mohamad Yahaya, Rizal Abd Rani, Mycobacterium tuberculosis (MTB) is a rare cause of prosthetic joint infection. The diagnosis is challenging especially in cases of latent tuberculosis. QuantiFERON-TB Gold (QFT®) is an interferon-gamma relative assay (IGRA) which is highly specific and sensitive for detection of MTB infection. We report a case of 76-year-old lady diagnosed with tuberculous prosthetic joint infection following total knee replacement. Histological examination of abnormal synovial tissue taken intraoperatively reveals chronic granulomatous lesion and raised suspicion of tuberculous infection in otherwise asymptomatic patient. The tuberculin skin test, MTB acid-fast stain and tuberculosis polymerase chain reaction were negative. The diagnosis dilemma was solved with positive result of QuantiFERON TB Gold Test. The patient was treated with anti-tuberculous drug without any surgical intervention. At five months follow-up, patient was clinically well with no symptoms and signs of infection. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12553/1/5._norliyana_m_et_al.pdf Norliyana M, and Nor Hamdan Mohamad Yahaya, and Rizal Abd Rani, (2018) Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report. Journal of Surgical Academia, 8 (1). pp. 28-31. ISSN 2231-7481 http://jsurgacad.com/toc/8/1
repository_type Digital Repository
institution_category Local University
institution Universiti Kebangasaan Malaysia
building UKM Institutional Repository
collection Online Access
language English
description Mycobacterium tuberculosis (MTB) is a rare cause of prosthetic joint infection. The diagnosis is challenging especially in cases of latent tuberculosis. QuantiFERON-TB Gold (QFT®) is an interferon-gamma relative assay (IGRA) which is highly specific and sensitive for detection of MTB infection. We report a case of 76-year-old lady diagnosed with tuberculous prosthetic joint infection following total knee replacement. Histological examination of abnormal synovial tissue taken intraoperatively reveals chronic granulomatous lesion and raised suspicion of tuberculous infection in otherwise asymptomatic patient. The tuberculin skin test, MTB acid-fast stain and tuberculosis polymerase chain reaction were negative. The diagnosis dilemma was solved with positive result of QuantiFERON TB Gold Test. The patient was treated with anti-tuberculous drug without any surgical intervention. At five months follow-up, patient was clinically well with no symptoms and signs of infection.
format Article
author Norliyana M,
Nor Hamdan Mohamad Yahaya,
Rizal Abd Rani,
spellingShingle Norliyana M,
Nor Hamdan Mohamad Yahaya,
Rizal Abd Rani,
Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report
author_facet Norliyana M,
Nor Hamdan Mohamad Yahaya,
Rizal Abd Rani,
author_sort Norliyana M,
title Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report
title_short Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report
title_full Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report
title_fullStr Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report
title_full_unstemmed Role of QuantiFERON TB gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report
title_sort role of quantiferon tb gold test for diagnosis of tuberculosis infection in prosthetic knee joint: a case report
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/12553/
http://journalarticle.ukm.my/12553/
http://journalarticle.ukm.my/12553/1/5._norliyana_m_et_al.pdf
first_indexed 2023-09-18T20:02:52Z
last_indexed 2023-09-18T20:02:52Z
_version_ 1777406965154054144

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