Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation

During induction of general anaesthesia, the act of laryngoscopy and tracheal intubation stimulates the sympathetic nervous system resulting in an increase in blood pressure and heart rate which may be harmful especially in elderly patients with pre-existing ischaemic heart disease. Several drugs ha...

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Main Authors:	Norhuzaimah J, Liu, Chian Yong, Muhammad Maaya, Ooi Su Min, Joanna Su Min
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12551/ http://journalarticle.ukm.my/12551/ http://journalarticle.ukm.my/12551/1/3._norhuzaimah_et_al._.pdf

id	ukm-12551
recordtype	eprints
spelling	ukm-125512019-02-12T00:10:33Z http://journalarticle.ukm.my/12551/ Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation Norhuzaimah J, Liu, Chian Yong Muhammad Maaya, Ooi Su Min, Joanna Su Min During induction of general anaesthesia, the act of laryngoscopy and tracheal intubation stimulates the sympathetic nervous system resulting in an increase in blood pressure and heart rate which may be harmful especially in elderly patients with pre-existing ischaemic heart disease. Several drugs have therefore been used to obtund this increase including esmolol, nicardipine, magnesium sulphate and lignocaine. This prospective, double blind randomised clinical trial compared the efficacy of magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and tracheal intubation. One hundred and twenty six ASA I-II patients scheduled for elective surgery requiring general anaesthesia with tracheal intubation were enrolled and randomised into two groups: Group 1 (n = 67) received MgSO4 40 mg/kg diluted in 100 ml normal saline administered over ten minutes, whereas Group 2 (n = 59) received a bolus of esmolol 1.0 mg/kg diluted to 10 ml. Systolic and diastolic blood pressures and heart rate were recorded every minute for subsequent 10 minutes following laryngoscopy and tracheal intubation. Attenuation of the mean systolic and diastolic blood pressures following laryngoscopy and tracheal intubation was significantly larger in Group 2 compared to Group 1. Patients in Group 2 had significantly better suppression of heart rate response compared to Group 1 during the first four minutes after laryngoscopy and tracheal intubation (p<0.05). Attenuation of the haemodynamic response to laryngoscopy and tracheal intubation by esmolol 1.0 mg/kg was more pronounced compared to MgSO4 40 mg/kg in normotensive patients undergoing general anaesthesia for elective surgery. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12551/1/3._norhuzaimah_et_al._.pdf Norhuzaimah J, and Liu, Chian Yong and Muhammad Maaya, and Ooi Su Min, Joanna Su Min (2018) Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation. Journal of Surgical Academia, 8 (1). pp. 16-22. ISSN 2231-7481 http://jsurgacad.com/toc/8/1
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	During induction of general anaesthesia, the act of laryngoscopy and tracheal intubation stimulates the sympathetic nervous system resulting in an increase in blood pressure and heart rate which may be harmful especially in elderly patients with pre-existing ischaemic heart disease. Several drugs have therefore been used to obtund this increase including esmolol, nicardipine, magnesium sulphate and lignocaine. This prospective, double blind randomised clinical trial compared the efficacy of magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and tracheal intubation. One hundred and twenty six ASA I-II patients scheduled for elective surgery requiring general anaesthesia with tracheal intubation were enrolled and randomised into two groups: Group 1 (n = 67) received MgSO4 40 mg/kg diluted in 100 ml normal saline administered over ten minutes, whereas Group 2 (n = 59) received a bolus of esmolol 1.0 mg/kg diluted to 10 ml. Systolic and diastolic blood pressures and heart rate were recorded every minute for subsequent 10 minutes following laryngoscopy and tracheal intubation. Attenuation of the mean systolic and diastolic blood pressures following laryngoscopy and tracheal intubation was significantly larger in Group 2 compared to Group 1. Patients in Group 2 had significantly better suppression of heart rate response compared to Group 1 during the first four minutes after laryngoscopy and tracheal intubation (p<0.05). Attenuation of the haemodynamic response to laryngoscopy and tracheal intubation by esmolol 1.0 mg/kg was more pronounced compared to MgSO4 40 mg/kg in normotensive patients undergoing general anaesthesia for elective surgery.
format	Article
author	Norhuzaimah J, Liu, Chian Yong Muhammad Maaya, Ooi Su Min, Joanna Su Min
spellingShingle	Norhuzaimah J, Liu, Chian Yong Muhammad Maaya, Ooi Su Min, Joanna Su Min Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation
author_facet	Norhuzaimah J, Liu, Chian Yong Muhammad Maaya, Ooi Su Min, Joanna Su Min
author_sort	Norhuzaimah J,
title	Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation
title_short	Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation
title_full	Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation
title_fullStr	Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation
title_full_unstemmed	Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation
title_sort	comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12551/ http://journalarticle.ukm.my/12551/ http://journalarticle.ukm.my/12551/1/3._norhuzaimah_et_al._.pdf
first_indexed	2023-09-18T20:02:52Z
last_indexed	2023-09-18T20:02:52Z
_version_	1777406964859404288

Comparison between magnesium sulphate and esmolol in attenuating haemodynamic responses to laryngoscopy and endotracheal intubation

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