Multi-disciplinary approach for managing plasmacytoma: a case report

Solitary plasmacytoma (SP) is a tumor with evidence of clonal plasma cells and no other features of multiple myeloma (MM). We report a case of SP which showed multiple recurrences of SP and then evolution into overt MM. A 56-year-old man presented with the 5-month-history of right nasal obstruction...

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Main Authors:	Wint Wint Thu Nyunt, Rahayu Draman, Aida Widure Mohd Mustapha, Noralisa Abdul Karim, Mohd Razif Mohd Idris, Noraimy Abdullah, Tang, Yee Loong, Wan Fariza Wan Jamaludin, Noraidah Masir, S Fadilah S Abdul Wahid
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12402/ http://journalarticle.ukm.my/12402/ http://journalarticle.ukm.my/12402/1/20%20Wint%20Wint%20Thu%20Nyunt.pdf

id	ukm-12402
recordtype	eprints
spelling	ukm-124022018-12-07T23:36:20Z http://journalarticle.ukm.my/12402/ Multi-disciplinary approach for managing plasmacytoma: a case report Wint Wint Thu Nyunt, Rahayu Draman, Aida Widure Mohd Mustapha, Noralisa Abdul Karim, Mohd Razif Mohd Idris, Noraimy Abdullah, Tang, Yee Loong Wan Fariza Wan Jamaludin, Noraidah Masir, S Fadilah S Abdul Wahid, Solitary plasmacytoma (SP) is a tumor with evidence of clonal plasma cells and no other features of multiple myeloma (MM). We report a case of SP which showed multiple recurrences of SP and then evolution into overt MM. A 56-year-old man presented with the 5-month-history of right nasal obstruction and intermittent epistaxis. He had SP (extraosseous) of right nasopharynx (3.5 × 2 × 2.5 cm), with no paraproteinaemia. He received radiotherapy (56 Gy), achieving complete remission. Ten years later, he had recurrence of SP (osseous) in left tibia, presenting with pathological fracture. He received radiotherapy (50 Gy), achieving partial response. Three years later, he had recurrence of SP (osseous) in right tibia, presenting with right leg pain. He received radiotherapy (45 Gy). While receiving treatment, he had progressive swelling in the area around right eye, double vision and headache. Imaging scans showed multiple plasmacytomas. There were presence of monoclonal paraprotein, hypercalcemia and lytic bone lesions. He was diagnosed as MM (at the age of 70 years) and treated with Bortezomib-based therapy. Currently, after one cycle of treatment, clinical improvement is achieved. The importance of multi-disciplinary team approach for managing patients with plasmacytoma is highlighted in order to achieve the holistic approach of management. Penerbit Universiti Kebangsaan Malaysia 2018-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12402/1/20%20Wint%20Wint%20Thu%20Nyunt.pdf Wint Wint Thu Nyunt, and Rahayu Draman, and Aida Widure Mohd Mustapha, and Noralisa Abdul Karim, and Mohd Razif Mohd Idris, and Noraimy Abdullah, and Tang, Yee Loong and Wan Fariza Wan Jamaludin, and Noraidah Masir, and S Fadilah S Abdul Wahid, (2018) Multi-disciplinary approach for managing plasmacytoma: a case report. Sains Malaysiana, 47 (9). pp. 2113-2118. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num9_2018/contentsVol47num9_2018.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Solitary plasmacytoma (SP) is a tumor with evidence of clonal plasma cells and no other features of multiple myeloma (MM). We report a case of SP which showed multiple recurrences of SP and then evolution into overt MM. A 56-year-old man presented with the 5-month-history of right nasal obstruction and intermittent epistaxis. He had SP (extraosseous) of right nasopharynx (3.5 × 2 × 2.5 cm), with no paraproteinaemia. He received radiotherapy (56 Gy), achieving complete remission. Ten years later, he had recurrence of SP (osseous) in left tibia, presenting with pathological fracture. He received radiotherapy (50 Gy), achieving partial response. Three years later, he had recurrence of SP (osseous) in right tibia, presenting with right leg pain. He received radiotherapy (45 Gy). While receiving treatment, he had progressive swelling in the area around right eye, double vision and headache. Imaging scans showed multiple plasmacytomas. There were presence of monoclonal paraprotein, hypercalcemia and lytic bone lesions. He was diagnosed as MM (at the age of 70 years) and treated with Bortezomib-based therapy. Currently, after one cycle of treatment, clinical improvement is achieved. The importance of multi-disciplinary team approach for managing patients with plasmacytoma is highlighted in order to achieve the holistic approach of management.
format	Article
author	Wint Wint Thu Nyunt, Rahayu Draman, Aida Widure Mohd Mustapha, Noralisa Abdul Karim, Mohd Razif Mohd Idris, Noraimy Abdullah, Tang, Yee Loong Wan Fariza Wan Jamaludin, Noraidah Masir, S Fadilah S Abdul Wahid,
spellingShingle	Wint Wint Thu Nyunt, Rahayu Draman, Aida Widure Mohd Mustapha, Noralisa Abdul Karim, Mohd Razif Mohd Idris, Noraimy Abdullah, Tang, Yee Loong Wan Fariza Wan Jamaludin, Noraidah Masir, S Fadilah S Abdul Wahid, Multi-disciplinary approach for managing plasmacytoma: a case report
author_facet	Wint Wint Thu Nyunt, Rahayu Draman, Aida Widure Mohd Mustapha, Noralisa Abdul Karim, Mohd Razif Mohd Idris, Noraimy Abdullah, Tang, Yee Loong Wan Fariza Wan Jamaludin, Noraidah Masir, S Fadilah S Abdul Wahid,
author_sort	Wint Wint Thu Nyunt,
title	Multi-disciplinary approach for managing plasmacytoma: a case report
title_short	Multi-disciplinary approach for managing plasmacytoma: a case report
title_full	Multi-disciplinary approach for managing plasmacytoma: a case report
title_fullStr	Multi-disciplinary approach for managing plasmacytoma: a case report
title_full_unstemmed	Multi-disciplinary approach for managing plasmacytoma: a case report
title_sort	multi-disciplinary approach for managing plasmacytoma: a case report
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12402/ http://journalarticle.ukm.my/12402/ http://journalarticle.ukm.my/12402/1/20%20Wint%20Wint%20Thu%20Nyunt.pdf
first_indexed	2023-09-18T20:02:32Z
last_indexed	2023-09-18T20:02:32Z
_version_	1777406943746326528

Multi-disciplinary approach for managing plasmacytoma: a case report

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