$The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)$

The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)

The pathophysiology of systemic inflammatory response syndrome (SIRS) had been described to involve various strong oxidative reactions affecting the status and progress of the patients. Antioxidant therapy had been suggested in many studies involving SIRS management. The objective of this study was...

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Main Authors:	Husam YE, Raha Abdul Rahman, Jaafar MZ, Mohd Heikal Mohd Yunus
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/12278/ http://journalarticle.ukm.my/12278/ http://journalarticle.ukm.my/12278/1/2._husam_et_al.pdf

id	ukm-12278
recordtype	eprints
spelling	ukm-122782018-11-02T21:48:17Z http://journalarticle.ukm.my/12278/ The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS) Husam YE, Raha Abdul Rahman, Jaafar MZ, Mohd Heikal Mohd Yunus, The pathophysiology of systemic inflammatory response syndrome (SIRS) had been described to involve various strong oxidative reactions affecting the status and progress of the patients. Antioxidant therapy had been suggested in many studies involving SIRS management. The objective of this study was to compare the role of vitamin E Tocotrienol and vitamin E Tocopherol combined with vitamin C as antioxidant therapy in the management of critically ill patients diagnosed with SIRS, admitted to the intensive care unit and high dependency wards of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). It was a single blind randomized clinical trial with a total of 72 patients in which 44.4% Malays, 34.7% Chinese, 19.4% Indians and 1.4% others with 59.7% males and 40.3% females were recruited. Patients in TRI E group received Tocotrienol with Vitamin C while TOCO group received Tocopherol with Vitamin C and a control group did not receive any antioxidant. The clinical parameters (heart rate, respiratory rate, systolic blood pressure) showed improvements with significant difference at the end of study (post-intervention) as compared to admission (pre-intervention).Whereas, the sepsis (temperature, PCT, CRP and WBC) and oxidative stress (8-OHdG/Creatinine) parameters showed improvements with significant difference at the end of study (post-intervention) as compared to admission (pre-intervention). The TRI E group showed obvious improvement in clinical, sepsis and oxidative stress parameters, as compared to TOCO and control groups. This study showed that Vitamin E Tocotrienol and Vitamin E Tocopherol in combination with Vitamin C demonstrated significant improvement in the clinical and laboratory parameters during the management of SIRS. Therefore, Vitamin E in combination with Vitamin C had therapeutic benefits in the treatment of critically ill patients with SIRS. Pusat Perubatan Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12278/1/2._husam_et_al.pdf Husam YE, and Raha Abdul Rahman, and Jaafar MZ, and Mohd Heikal Mohd Yunus, (2017) The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS). Journal of Surgical Academia, 7 (2). pp. 4-12. ISSN 2231-7481 http://jsurgacad.com/toc/7/2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	The pathophysiology of systemic inflammatory response syndrome (SIRS) had been described to involve various strong oxidative reactions affecting the status and progress of the patients. Antioxidant therapy had been suggested in many studies involving SIRS management. The objective of this study was to compare the role of vitamin E Tocotrienol and vitamin E Tocopherol combined with vitamin C as antioxidant therapy in the management of critically ill patients diagnosed with SIRS, admitted to the intensive care unit and high dependency wards of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). It was a single blind randomized clinical trial with a total of 72 patients in which 44.4% Malays, 34.7% Chinese, 19.4% Indians and 1.4% others with 59.7% males and 40.3% females were recruited. Patients in TRI E group received Tocotrienol with Vitamin C while TOCO group received Tocopherol with Vitamin C and a control group did not receive any antioxidant. The clinical parameters (heart rate, respiratory rate, systolic blood pressure) showed improvements with significant difference at the end of study (post-intervention) as compared to admission (pre-intervention).Whereas, the sepsis (temperature, PCT, CRP and WBC) and oxidative stress (8-OHdG/Creatinine) parameters showed improvements with significant difference at the end of study (post-intervention) as compared to admission (pre-intervention). The TRI E group showed obvious improvement in clinical, sepsis and oxidative stress parameters, as compared to TOCO and control groups. This study showed that Vitamin E Tocotrienol and Vitamin E Tocopherol in combination with Vitamin C demonstrated significant improvement in the clinical and laboratory parameters during the management of SIRS. Therefore, Vitamin E in combination with Vitamin C had therapeutic benefits in the treatment of critically ill patients with SIRS.
format	Article
author	Husam YE, Raha Abdul Rahman, Jaafar MZ, Mohd Heikal Mohd Yunus,
spellingShingle	Husam YE, Raha Abdul Rahman, Jaafar MZ, Mohd Heikal Mohd Yunus, The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)
author_facet	Husam YE, Raha Abdul Rahman, Jaafar MZ, Mohd Heikal Mohd Yunus,
author_sort	Husam YE,
title	The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)
title_short	The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)
title_full	The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)
title_fullStr	The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)
title_full_unstemmed	The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)
title_sort	effectiveness of tocotrienol rich fraction and αlpha tocoferol with combination of vitamin c in the management of systemic inflammatory response syndrome (sirs)
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/12278/ http://journalarticle.ukm.my/12278/ http://journalarticle.ukm.my/12278/1/2._husam_et_al.pdf
first_indexed	2023-09-18T20:02:15Z
last_indexed	2023-09-18T20:02:15Z
_version_	1777406926352547840

The effectiveness of Tocotrienol rich fraction and αlpha Tocoferol with combination of vitamin C in the management of systemic inflammatory response syndrome (SIRS)

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