Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells

A study was conducted to investigate the antiviral activity of aqueous extracts from Orthosiphon stamineus (OS). Extraction was done using different parts of OS. The whole plant except root (WPOS), leaves (LOS) and flowers (FOS) of OS were extracted using aqueous extraction method. Cytotoxicity was...

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Main Authors:	Nur Suhana Mohamad Ripim, Nuraini Fazil, Saidatul Nadrah Kholid Ibrahim, Adibah Ahamad Bahtiar, Yip, Chee Wai, Nazlina Ibrahim, Norefrina Shafinaz Md Nor
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/12193/ http://journalarticle.ukm.my/12193/ http://journalarticle.ukm.my/12193/1/11%20Nur%20Suhana%20Mohamad%20Ripim.pdf

id	ukm-12193
recordtype	eprints
spelling	ukm-121932018-10-16T13:41:18Z http://journalarticle.ukm.my/12193/ Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells Nur Suhana Mohamad Ripim, Nuraini Fazil, Saidatul Nadrah Kholid Ibrahim, Adibah Ahamad Bahtiar, Yip, Chee Wai Nazlina Ibrahim, Norefrina Shafinaz Md Nor, A study was conducted to investigate the antiviral activity of aqueous extracts from Orthosiphon stamineus (OS). Extraction was done using different parts of OS. The whole plant except root (WPOS), leaves (LOS) and flowers (FOS) of OS were extracted using aqueous extraction method. Cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide (MTT) assay. Plaque reduction assays were carried out to evaluate the antiviral activity of OS extract against herpes simplex virus type 1 (HSV-1). These include post-treatment, pre-treatment and virucidal assays. High antiviral activity was observed in post-treatment and virucidal assay with 100% reduction of HSV-1 plaque at 0.39 mg/mL in LOS, FOS and WPOS. In pre-treatment assay, 79%, 84% and 97% plaque reduction using the same concentration was observed in FOS, LOS and WPOS, respectively. In conclusion, this study showed that OS aqueous extract has promising potential to be explored as anti-HSV-1 agent regardless of the mode of treatment. Penerbit Universiti Kebangsaan Malaysia 2018-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12193/1/11%20Nur%20Suhana%20Mohamad%20Ripim.pdf Nur Suhana Mohamad Ripim, and Nuraini Fazil, and Saidatul Nadrah Kholid Ibrahim, and Adibah Ahamad Bahtiar, and Yip, Chee Wai and Nazlina Ibrahim, and Norefrina Shafinaz Md Nor, (2018) Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells. Sains Malaysiana, 47 (8). pp. 1725-1730. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num8_2018/contentsVol47num8_2018.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	A study was conducted to investigate the antiviral activity of aqueous extracts from Orthosiphon stamineus (OS). Extraction was done using different parts of OS. The whole plant except root (WPOS), leaves (LOS) and flowers (FOS) of OS were extracted using aqueous extraction method. Cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide (MTT) assay. Plaque reduction assays were carried out to evaluate the antiviral activity of OS extract against herpes simplex virus type 1 (HSV-1). These include post-treatment, pre-treatment and virucidal assays. High antiviral activity was observed in post-treatment and virucidal assay with 100% reduction of HSV-1 plaque at 0.39 mg/mL in LOS, FOS and WPOS. In pre-treatment assay, 79%, 84% and 97% plaque reduction using the same concentration was observed in FOS, LOS and WPOS, respectively. In conclusion, this study showed that OS aqueous extract has promising potential to be explored as anti-HSV-1 agent regardless of the mode of treatment.
format	Article
author	Nur Suhana Mohamad Ripim, Nuraini Fazil, Saidatul Nadrah Kholid Ibrahim, Adibah Ahamad Bahtiar, Yip, Chee Wai Nazlina Ibrahim, Norefrina Shafinaz Md Nor,
spellingShingle	Nur Suhana Mohamad Ripim, Nuraini Fazil, Saidatul Nadrah Kholid Ibrahim, Adibah Ahamad Bahtiar, Yip, Chee Wai Nazlina Ibrahim, Norefrina Shafinaz Md Nor, Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells
author_facet	Nur Suhana Mohamad Ripim, Nuraini Fazil, Saidatul Nadrah Kholid Ibrahim, Adibah Ahamad Bahtiar, Yip, Chee Wai Nazlina Ibrahim, Norefrina Shafinaz Md Nor,
author_sort	Nur Suhana Mohamad Ripim,
title	Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells
title_short	Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells
title_full	Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells
title_fullStr	Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells
title_full_unstemmed	Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells
title_sort	antiviral properties of orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/12193/ http://journalarticle.ukm.my/12193/ http://journalarticle.ukm.my/12193/1/11%20Nur%20Suhana%20Mohamad%20Ripim.pdf
first_indexed	2023-09-18T20:02:04Z
last_indexed	2023-09-18T20:02:04Z
_version_	1777406914863300608

Antiviral properties of Orthosiphon stamineus aqueous extract in herpes simplex virus type 1 infected cells

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