Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels
PEG at compositions of 10, 15 and 20 g were added into the initial formulation of hydrogel L, which was composed of 6 g low molecular weight chitosan (LMC) and 14 g poly (vinyl pyrrolidone) in 100 g of 2% lactic acid. The mixtures were moulded and exposed to γ radiation at 7 kGy. The hydrogels obtai...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2018
|
| Online Access: | http://journalarticle.ukm.my/12123/ http://journalarticle.ukm.my/12123/ http://journalarticle.ukm.my/12123/1/14%20Maznah%20Mahmud.pdf |
| id |
ukm-12123 |
|---|---|
| recordtype |
eprints |
| spelling |
ukm-121232018-09-28T22:30:30Z http://journalarticle.ukm.my/12123/ Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels Maznah Mahmud, Rusli Daik, Zainah Adam, PEG at compositions of 10, 15 and 20 g were added into the initial formulation of hydrogel L, which was composed of 6 g low molecular weight chitosan (LMC) and 14 g poly (vinyl pyrrolidone) in 100 g of 2% lactic acid. The mixtures were moulded and exposed to γ radiation at 7 kGy. The hydrogels obtained were characterized in term of gel fraction, swelling property, syneresis effect, FTIR, XRD and cross section morphology. The results indicated PEG reduces almost 27% crosslinking density of the LMC-PVP hydrogel yet increased hydrogel’s water holding capacity from 450% and 480% to 750% and 650% in phosphate buffer solution (PBS) at pH5.5 and pH7.0, respectively. Also PEG enhanced the ability of LMC-PVP hydrogel to retain its moisture from dehydration at body temperature. The morphological study showed PEG developed thick pores wall and reduced the pores size of the hydrogels’ network. Penerbit Universiti Kebangsaan Malaysia 2018-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12123/1/14%20Maznah%20Mahmud.pdf Maznah Mahmud, and Rusli Daik, and Zainah Adam, (2018) Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels. Sains Malaysiana, 47 (6). pp. 1189-1197. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil6_2018/KandunganJilid47Bil6_2018.html |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
Universiti Kebangasaan Malaysia |
| building |
UKM Institutional Repository |
| collection |
Online Access |
| language |
English |
| description |
PEG at compositions of 10, 15 and 20 g were added into the initial formulation of hydrogel L, which was composed of 6 g low molecular weight chitosan (LMC) and 14 g poly (vinyl pyrrolidone) in 100 g of 2% lactic acid. The mixtures were moulded and exposed to γ radiation at 7 kGy. The hydrogels obtained were characterized in term of gel fraction, swelling property, syneresis effect, FTIR, XRD and cross section morphology. The results indicated PEG reduces almost 27% crosslinking density of the LMC-PVP hydrogel yet increased hydrogel’s water holding capacity from 450% and 480% to 750% and 650% in phosphate buffer solution (PBS) at pH5.5 and pH7.0, respectively. Also PEG enhanced the ability of LMC-PVP hydrogel to retain its moisture from dehydration at body temperature. The morphological study showed PEG developed thick pores wall and reduced the pores size of the hydrogels’ network. |
| format |
Article |
| author |
Maznah Mahmud, Rusli Daik, Zainah Adam, |
| spellingShingle |
Maznah Mahmud, Rusli Daik, Zainah Adam, Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels |
| author_facet |
Maznah Mahmud, Rusli Daik, Zainah Adam, |
| author_sort |
Maznah Mahmud, |
| title |
Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels |
| title_short |
Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels |
| title_full |
Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels |
| title_fullStr |
Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels |
| title_full_unstemmed |
Influence of poly (Ethylene Glycol) on the characteristics of γ radiation-crosslinked poly (Vinyl Pyrrolidone)-low molecular weight chitosan network hydrogels |
| title_sort |
influence of poly (ethylene glycol) on the characteristics of γ radiation-crosslinked poly (vinyl pyrrolidone)-low molecular weight chitosan network hydrogels |
| publisher |
Penerbit Universiti Kebangsaan Malaysia |
| publishDate |
2018 |
| url |
http://journalarticle.ukm.my/12123/ http://journalarticle.ukm.my/12123/ http://journalarticle.ukm.my/12123/1/14%20Maznah%20Mahmud.pdf |
| first_indexed |
2023-09-18T20:01:54Z |
| last_indexed |
2023-09-18T20:01:54Z |
| _version_ |
1777406904746639360 |