Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling
Mathematically, the human alimentary tract organs were simplified in the model structure as separate compartments with pathways of transfer that are kinetically homogenous and equally distributed. The development of gastro-compartment model follows the first order kinetics of differential equations...
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Penerbit Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/12045/ http://journalarticle.ukm.my/12045/ http://journalarticle.ukm.my/12045/1/23%20Yasmin%20Mohd%20Idris%20Perama.pdf |
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ukm-120452018-09-09T23:39:00Z http://journalarticle.ukm.my/12045/ Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling Yasmin Mohd Idris Perama, Nur Shahidah Abdul Rashid, Syazwani Mohd Fadzil, Khoo, Kok Siong Mathematically, the human alimentary tract organs were simplified in the model structure as separate compartments with pathways of transfer that are kinetically homogenous and equally distributed. The development of gastro-compartment model follows the first order kinetics of differential equations to describe cadmium absorption, distribution and elimination in the human digestive system. With the aid of in vitro DIN assay, an artificial gastric and gastrointestinal fluid were prepared using water leach purification (WLP) residue as a sample that contained toxic metals cadmium. The Simulation, Analysis and Modelling II (SAAM II) V2.1 software is employed to design models easily, simulate experiments quickly and analyze data accurately. Based on the experimental inputs and fractional transfer rates parameter incorporated to the gastro-compartment model, the concentration of cadmium against time profile curves were plotted as the model output. The curve presented concentration of cadmium in both gastric and gastrointestinal fluid where initially absorption phase (first hour) occurred followed by the distribution phase (second to third hours) and elimination process (third to fifth hours). The concentration of cadmium obtained from the simulated model structures was in good agreement with the fitted model predicted measurements as statistical t-test conducted showed the values were not significantly different. Therefore, modeling approach with SAAM II software gave realistic and better estimation of cadmium dissolution into the human gastrointestinal tract. Penerbit Universiti Kebangsaan Malaysia 2018-03 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/12045/1/23%20Yasmin%20Mohd%20Idris%20Perama.pdf Yasmin Mohd Idris Perama, and Nur Shahidah Abdul Rashid, and Syazwani Mohd Fadzil, and Khoo, Kok Siong (2018) Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling. Sains Malaysiana, 47 (3). pp. 611-618. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid47bil3_2018/KandunganJilid47Bil3_2018.html |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
Universiti Kebangasaan Malaysia |
| building |
UKM Institutional Repository |
| collection |
Online Access |
| language |
English |
| description |
Mathematically, the human alimentary tract organs were simplified in the model structure as separate compartments with pathways of transfer that are kinetically homogenous and equally distributed. The development of gastro-compartment model follows the first order kinetics of differential equations to describe cadmium absorption, distribution and elimination in the human digestive system. With the aid of in vitro DIN assay, an artificial gastric and gastrointestinal fluid were prepared using water leach purification (WLP) residue as a sample that contained toxic metals cadmium. The Simulation, Analysis and Modelling II (SAAM II) V2.1 software is employed to design models easily, simulate experiments quickly and analyze data accurately. Based on the experimental inputs and fractional transfer rates parameter incorporated to the gastro-compartment model, the concentration of cadmium against time profile curves were plotted as the model output. The curve presented concentration of cadmium in both gastric and gastrointestinal fluid where initially absorption phase (first hour) occurred followed by the distribution phase (second to third hours) and elimination process (third to fifth hours). The concentration of cadmium obtained from the simulated model structures was in good agreement with the fitted model predicted measurements as statistical t-test conducted showed the values were not significantly different. Therefore, modeling approach with SAAM II software gave realistic and better estimation of cadmium dissolution into the human gastrointestinal tract. |
| format |
Article |
| author |
Yasmin Mohd Idris Perama, Nur Shahidah Abdul Rashid, Syazwani Mohd Fadzil, Khoo, Kok Siong |
| spellingShingle |
Yasmin Mohd Idris Perama, Nur Shahidah Abdul Rashid, Syazwani Mohd Fadzil, Khoo, Kok Siong Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling |
| author_facet |
Yasmin Mohd Idris Perama, Nur Shahidah Abdul Rashid, Syazwani Mohd Fadzil, Khoo, Kok Siong |
| author_sort |
Yasmin Mohd Idris Perama, |
| title |
Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling |
| title_short |
Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling |
| title_full |
Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling |
| title_fullStr |
Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling |
| title_full_unstemmed |
Absorption, distribution and elimination behaviours of cadmium treated by in vitro DIN from WLP residue using SAAM II modeling |
| title_sort |
absorption, distribution and elimination behaviours of cadmium treated by in vitro din from wlp residue using saam ii modeling |
| publisher |
Penerbit Universiti Kebangsaan Malaysia |
| publishDate |
2018 |
| url |
http://journalarticle.ukm.my/12045/ http://journalarticle.ukm.my/12045/ http://journalarticle.ukm.my/12045/1/23%20Yasmin%20Mohd%20Idris%20Perama.pdf |
| first_indexed |
2023-09-18T20:01:44Z |
| last_indexed |
2023-09-18T20:01:44Z |
| _version_ |
1777406893793214464 |