STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer

STK15 is a serine/threonine kinase that regulates chromosomal segregation during mitosis. Single nucleotide polymorphisms (SNPs) in this gene, Phe31Ile (rs2273535) and Val57Ile (rs1047972), are inconsistently associated with gastrointestinal cancer (GIC) across different populations. However, this a...

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Main Authors:	Lai, Tianxin, Chong, Eric Tzyy Jiann, Chuah, Jitt Aun, Chua, Kek Heng, Lee, Ping-Chin
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2018
Online Access:	http://journalarticle.ukm.my/11990/ http://journalarticle.ukm.my/11990/ http://journalarticle.ukm.my/11990/1/17%20Tianxin%20Lai.pdf

id	ukm-11990
recordtype	eprints
spelling	ukm-119902018-08-14T01:44:44Z http://journalarticle.ukm.my/11990/ STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer Lai, Tianxin Chong, Eric Tzyy Jiann Chuah, Jitt Aun Chua, Kek Heng Lee, Ping-Chin STK15 is a serine/threonine kinase that regulates chromosomal segregation during mitosis. Single nucleotide polymorphisms (SNPs) in this gene, Phe31Ile (rs2273535) and Val57Ile (rs1047972), are inconsistently associated with gastrointestinal cancer (GIC) across different populations. However, this association is unclear in Malaysian population. Therefore, this study investigated the association of STK15 Phe31Ile and Val57Ile polymorphisms to GIC risk in Malaysia. Genomic DNA was extracted from 185 GIC patients and 1110 healthy controls and was subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. SNPs were further confirmed using sequencing. We found that the 31Phe allele and 31Phe/Phe genotype in the Phe31Ile SNP significantly increased GIC risk in Malaysian population, particularly in gastric cancer (p<0.017). The combined analysis for both SNPs also increased the risk of GIC in this study. Etiological factors such as age, gender and ethnicity were not associated with GIC in the population. This is the first study to report the association of STK15 Phe31Ile and Val57Ile SNPs with an increased risk of GIC in Malaysians; the 31Phe allele is exclusively associated with the risk of gastric cancer. In addition, GIC incidences among Malaysians have significantly shifted to a younger age (<50 years). Penerbit Universiti Kebangsaan Malaysia 2018-01 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11990/1/17%20Tianxin%20Lai.pdf Lai, Tianxin and Chong, Eric Tzyy Jiann and Chuah, Jitt Aun and Chua, Kek Heng and Lee, Ping-Chin (2018) STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer. Sains Malaysiana, 47 (1). pp. 141-148. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol47num1_2018/contentsVol47num1_2018.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	STK15 is a serine/threonine kinase that regulates chromosomal segregation during mitosis. Single nucleotide polymorphisms (SNPs) in this gene, Phe31Ile (rs2273535) and Val57Ile (rs1047972), are inconsistently associated with gastrointestinal cancer (GIC) across different populations. However, this association is unclear in Malaysian population. Therefore, this study investigated the association of STK15 Phe31Ile and Val57Ile polymorphisms to GIC risk in Malaysia. Genomic DNA was extracted from 185 GIC patients and 1110 healthy controls and was subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. SNPs were further confirmed using sequencing. We found that the 31Phe allele and 31Phe/Phe genotype in the Phe31Ile SNP significantly increased GIC risk in Malaysian population, particularly in gastric cancer (p<0.017). The combined analysis for both SNPs also increased the risk of GIC in this study. Etiological factors such as age, gender and ethnicity were not associated with GIC in the population. This is the first study to report the association of STK15 Phe31Ile and Val57Ile SNPs with an increased risk of GIC in Malaysians; the 31Phe allele is exclusively associated with the risk of gastric cancer. In addition, GIC incidences among Malaysians have significantly shifted to a younger age (<50 years).
format	Article
author	Lai, Tianxin Chong, Eric Tzyy Jiann Chuah, Jitt Aun Chua, Kek Heng Lee, Ping-Chin
spellingShingle	Lai, Tianxin Chong, Eric Tzyy Jiann Chuah, Jitt Aun Chua, Kek Heng Lee, Ping-Chin STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer
author_facet	Lai, Tianxin Chong, Eric Tzyy Jiann Chuah, Jitt Aun Chua, Kek Heng Lee, Ping-Chin
author_sort	Lai, Tianxin
title	STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer
title_short	STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer
title_full	STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer
title_fullStr	STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer
title_full_unstemmed	STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer
title_sort	stk15 phe31ile and val57ile polymorphisms increase the risk of gastrointestinal cancer
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2018
url	http://journalarticle.ukm.my/11990/ http://journalarticle.ukm.my/11990/ http://journalarticle.ukm.my/11990/1/17%20Tianxin%20Lai.pdf
first_indexed	2023-09-18T20:01:36Z
last_indexed	2023-09-18T20:01:36Z
_version_	1777406885720227840

STK15 Phe31Ile and Val57Ile polymorphisms increase the risk of gastrointestinal cancer

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