The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML

Acute myeloid leukaemia (AML) is the most common subtype of acute leukaemias with a poor outcome. Msi2 protein is a newly discovered prognostic marker and it has been considered as a new target for therapy in AML. The study of Msi2 protein expression in AML cases has not been performed in Malaysia,...

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Main Authors:	Bakheet, Omayma Saad Eldeen, Nurasyikin Y, Azma RZ, Suria Abdul Aziz, Chandramaya S, Noraidah Masir
Format:	Article
Language:	English
Published:	Pusat Perubatan Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11866/ http://journalarticle.ukm.my/11866/ http://journalarticle.ukm.my/11866/1/8_omayma_et_al_pdf_17877.pdf

id	ukm-11866
recordtype	eprints
spelling	ukm-118662018-07-10T04:26:44Z http://journalarticle.ukm.my/11866/ The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML Bakheet, Omayma Saad Eldeen Nurasyikin Y, Azma RZ, Suria Abdul Aziz, Chandramaya S, Noraidah Masir, Acute myeloid leukaemia (AML) is the most common subtype of acute leukaemias with a poor outcome. Msi2 protein is a newly discovered prognostic marker and it has been considered as a new target for therapy in AML. The study of Msi2 protein expression in AML cases has not been performed in Malaysia, to date. The main aim of the present study was to observe the expression of Msi2 protein in AML patients by immunohistochemistry (IHC) and to correlate its expression with the well-established prognostic and clinical parameters in AML as well as the overall survival (OS). Sixty four bone marrow trephine biopsy sections were immunostained for Msi2 protein. The percentage of blasts with positive reaction and the intensity of the cytoplasmic and nuclear staining were evaluated. The expression of Msi2 protein was found in 95.3% cases with Msi2 pattern varying between the cases. In 71.9% of cases, the blasts showed total cellular positivity and 23.4% cases showed only cytoplasmic positivity. Majority showed high expression of Msi2 for cytoplasmic staining. Interestingly, there was significant correlation between total cellular staining and the intermediate cytogenetic subgroup (P= 0.04). In conclusion, the results showed that the majority of the patients had high expression of Msi2 but this did not correlate to OS. However, the Msi2 expression correlated to the cytogenetic findings. The results suggest future extensive research to be conducted in order to ascertain the exact role of Msi2 positive blast cells in AML in our population and their association with prognosis and outcome. Pusat Perubatan Universiti Kebangsaan Malaysia 2017 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11866/1/8_omayma_et_al_pdf_17877.pdf Bakheet, Omayma Saad Eldeen and Nurasyikin Y, and Azma RZ, and Suria Abdul Aziz, and Chandramaya S, and Noraidah Masir, (2017) The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML. Medicine & Health, 12 (1). pp. 66-82. ISSN 2289-5728 http://www.medicineandhealthukm.com/toc/12/1
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Acute myeloid leukaemia (AML) is the most common subtype of acute leukaemias with a poor outcome. Msi2 protein is a newly discovered prognostic marker and it has been considered as a new target for therapy in AML. The study of Msi2 protein expression in AML cases has not been performed in Malaysia, to date. The main aim of the present study was to observe the expression of Msi2 protein in AML patients by immunohistochemistry (IHC) and to correlate its expression with the well-established prognostic and clinical parameters in AML as well as the overall survival (OS). Sixty four bone marrow trephine biopsy sections were immunostained for Msi2 protein. The percentage of blasts with positive reaction and the intensity of the cytoplasmic and nuclear staining were evaluated. The expression of Msi2 protein was found in 95.3% cases with Msi2 pattern varying between the cases. In 71.9% of cases, the blasts showed total cellular positivity and 23.4% cases showed only cytoplasmic positivity. Majority showed high expression of Msi2 for cytoplasmic staining. Interestingly, there was significant correlation between total cellular staining and the intermediate cytogenetic subgroup (P= 0.04). In conclusion, the results showed that the majority of the patients had high expression of Msi2 but this did not correlate to OS. However, the Msi2 expression correlated to the cytogenetic findings. The results suggest future extensive research to be conducted in order to ascertain the exact role of Msi2 positive blast cells in AML in our population and their association with prognosis and outcome.
format	Article
author	Bakheet, Omayma Saad Eldeen Nurasyikin Y, Azma RZ, Suria Abdul Aziz, Chandramaya S, Noraidah Masir,
spellingShingle	Bakheet, Omayma Saad Eldeen Nurasyikin Y, Azma RZ, Suria Abdul Aziz, Chandramaya S, Noraidah Masir, The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML
author_facet	Bakheet, Omayma Saad Eldeen Nurasyikin Y, Azma RZ, Suria Abdul Aziz, Chandramaya S, Noraidah Masir,
author_sort	Bakheet, Omayma Saad Eldeen
title	The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML
title_short	The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML
title_full	The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML
title_fullStr	The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML
title_full_unstemmed	The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML
title_sort	msi2 protein expression positive correlation with favorable cytogenetics findings in aml
publisher	Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/11866/ http://journalarticle.ukm.my/11866/ http://journalarticle.ukm.my/11866/1/8_omayma_et_al_pdf_17877.pdf
first_indexed	2023-09-18T20:01:19Z
last_indexed	2023-09-18T20:01:19Z
_version_	1777406867895484416

The Msi2 protein expression positive correlation with favorable cytogenetics findings in AML

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