$The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion$

The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion

Exposure to organophosphate pesticide including fenitrothion (FNT) has led to many adverse effects on human health. However, a potent antioxidant like palm oil tocotrienol-rich fraction (TRF) can reduce oxidative damage in various pathological conditions, could also reduce the adverse effects by FNT...

Full description

Bibliographic Details
Main Authors:	Putri Ayu Jayusman, Siti Balkis Budin, Izatus Shima Taib, Ahmad Rohi Ghazali
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11389/ http://journalarticle.ukm.my/11389/ http://journalarticle.ukm.my/11389/1/32%20Putri%20Ayu%20Jayusman.pdf

id	ukm-11389
recordtype	eprints
spelling	ukm-113892018-02-15T05:26:36Z http://journalarticle.ukm.my/11389/ The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion Putri Ayu Jayusman, Siti Balkis Budin, Izatus Shima Taib, Ahmad Rohi Ghazali, Exposure to organophosphate pesticide including fenitrothion (FNT) has led to many adverse effects on human health. However, a potent antioxidant like palm oil tocotrienol-rich fraction (TRF) can reduce oxidative damage in various pathological conditions, could also reduce the adverse effects by FNT. The aim of this study was to evaluate the effect of TRF on oxidative liver damage in FNT induce hepatotoxicity in experimental rats. A total of 40 male Sprague-Dawley rats were randomly divided into four groups of 10, namely control, TRF, FNT and TRF+FNT group. TRF (200 mg/kg body weight) and FNT (20 m/kg body weight) were administered through oral gavage for 28 days. Corn oil which served as vehicle was given orally to the control group. At the end of the study period, liver and blood was taken for oxidative damage and biochemical evaluation and histological observation. TRF supplementation prevents oxidative liver damage by reducing the hepatic malondialdehyde (MDA) and protein carbonyl (PCO) level significantly. Besides, TRF also restored the endogenous antioxidants particularly reduced glutathione (GSH), glutathione peroxidase (GPx) and ferric reducing/antioxidant power (FRAP). TRF also prevent liver damage by reducing the liver enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The attenuation of liver damage by TRF was also showed histologically. In conclusion, TRF supplementation showed a potential in preventing oxidative liver damage in FNT-treated rats by reducing the oxidative damage and improving the antioxidant status. Penerbit Universiti Kebangsaan Malaysia 2017-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11389/1/32%20Putri%20Ayu%20Jayusman.pdf Putri Ayu Jayusman, and Siti Balkis Budin, and Izatus Shima Taib, and Ahmad Rohi Ghazali, (2017) The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion. Sains Malaysiana, 46 (9). pp. 1603-1609. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num9_2017/contentsVol46num9_2017.html
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Exposure to organophosphate pesticide including fenitrothion (FNT) has led to many adverse effects on human health. However, a potent antioxidant like palm oil tocotrienol-rich fraction (TRF) can reduce oxidative damage in various pathological conditions, could also reduce the adverse effects by FNT. The aim of this study was to evaluate the effect of TRF on oxidative liver damage in FNT induce hepatotoxicity in experimental rats. A total of 40 male Sprague-Dawley rats were randomly divided into four groups of 10, namely control, TRF, FNT and TRF+FNT group. TRF (200 mg/kg body weight) and FNT (20 m/kg body weight) were administered through oral gavage for 28 days. Corn oil which served as vehicle was given orally to the control group. At the end of the study period, liver and blood was taken for oxidative damage and biochemical evaluation and histological observation. TRF supplementation prevents oxidative liver damage by reducing the hepatic malondialdehyde (MDA) and protein carbonyl (PCO) level significantly. Besides, TRF also restored the endogenous antioxidants particularly reduced glutathione (GSH), glutathione peroxidase (GPx) and ferric reducing/antioxidant power (FRAP). TRF also prevent liver damage by reducing the liver enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The attenuation of liver damage by TRF was also showed histologically. In conclusion, TRF supplementation showed a potential in preventing oxidative liver damage in FNT-treated rats by reducing the oxidative damage and improving the antioxidant status.
format	Article
author	Putri Ayu Jayusman, Siti Balkis Budin, Izatus Shima Taib, Ahmad Rohi Ghazali,
spellingShingle	Putri Ayu Jayusman, Siti Balkis Budin, Izatus Shima Taib, Ahmad Rohi Ghazali, The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion
author_facet	Putri Ayu Jayusman, Siti Balkis Budin, Izatus Shima Taib, Ahmad Rohi Ghazali,
author_sort	Putri Ayu Jayusman,
title	The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion
title_short	The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion
title_full	The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion
title_fullStr	The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion
title_full_unstemmed	The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion
title_sort	effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/11389/ http://journalarticle.ukm.my/11389/ http://journalarticle.ukm.my/11389/1/32%20Putri%20Ayu%20Jayusman.pdf
first_indexed	2023-09-18T20:00:12Z
last_indexed	2023-09-18T20:00:12Z
_version_	1777406797078855680

The effect of tocotrienol-rich fraction on oxidative liver damage induced by fenitrothion

Similar Items